MCT1-dependent mitochondrial lactate import sustains cardiac metabolism
Human heart samples Human myocardial tissue samples were acquired from patients through the Utah Cardiac Recovery Program at…
The chemical fingerprint of cellular senescence – Nature
The chemical fingerprint of cellular senescence NatureMayo Clinic research advances understanding of senescent ‘zombie’ cells, healthy aging South Florida Hospital…
The blood metabolome of brain health in midlife and influences of genes, microbiome and exposome
Study populationRotterdam Study The Rotterdam Study is a prospective population-based study from the Ommoord district of Rotterdam, The…
Inhibition of IRAK4 by microbial trimethylamine blunts metabolic inflammation and ameliorates glycemic control
Protocols All experimental procedures involving mice were carried out in accordance with UK Home Office, Canadian Council on…
Genetic architecture of plasma metabolome in 254,825 individuals
Population characteristics We included 254,825 UKB participants with both metabolomic and genomic data available after quality control. The…
MSnLib: efficient generation of open multi-stage fragmentation mass spectral libraries
Materials All solvents used were of LC–MS grade. Methanol, acetonitrile, water and formic acid were obtained from Thermo…