Spatial signatures for predicting immunotherapy outcomes using multi-omics in non-small cell lung cancer
Study population We studied three independent cohorts of patients with NSCLC who were treated with PD-1-based immunotherapies in…
AI Model Finds Gene Targets and Drug Combos to Reprogram Diseased Cells
Credit: FlashMovie/Getty Images Traditional drug discovery has often followed the “one drug, one target” paradigm—developing compounds against individual…
Clone copy number diversity is linked to survival in lung cancer
The ALPACA algorithm We introduce ALPACA, an algorithm to infer allele-specific copy-number profiles of every tumour clone, given…