MSnLib: efficient generation of open multi-stage fragmentation mass spectral libraries
Materials All solvents used were of LC–MS grade. Methanol, acetonitrile, water and formic acid were obtained from Thermo…
Investigating the role of transposable elements in shaping abdominal fat and egg production phenotypic traits in geese | BMC Genomics
Shi X, Wang J, Zeng F, Qiu X. Mitochondrial DNA cleavage patterns distinguish independent origin of Chinese domestic…
Imaging-based multimodal profiling of single cells with STAMP
Single-cell RNA sequencing (scRNA-seq) has dramatically advanced our ability to dissect complex biological systems at cellular resolution. However,…
Genetic markers could help prevent age-related frailty
New research links previously unknown genes to frailty, raising hope for early predicting and preventing age-related decline. Study:Â Large-scale…
Morphological map of under- and overexpression of genes in human cells
Mattiazzi Usaj, M. et al. High-content screening for quantitative cell biology. Trends Cell Biol. 26, 598–611 (2016). CAS …
New insights into how genes influence frailty in older adults
A new study has identified genetic variants linked to brain function, immune defense and metabolism that contribute to…
The Platinum Pedigree: a long-read benchmark for genetic variants
Gonzaga-Jauregui, C., Lupski, J. R. & Gibbs, R. A. Human genome sequencing in health and disease. Annu. Rev.…
Deep-learning-based gene perturbation effect prediction does not yet outperform simple linear baselines
The success of large language models in knowledge representation has spawned efforts to apply the foundation model concept…
GeneAgent: self-verification language agent for gene-set analysis using domain databases
Model setting and data collection In this work, we utilized GPT-4 (version 20230613) as the backend model via…
Population-level gene copy number variations reveal distinct genetic properties of different Malus species | BMC Genomics
Weischenfeldt J, Symmons O, Spitz F, Korbel JO. Phenotypic impact of genomic structural variation: insights from and for…
![An AI-designed protein binder (purple and pink) envelops the flexible hormone amylin (white), preventing it from forming toxic fibrils linked to type 2 diabetes in lab tests. [Ian Haydon]](https://www.newsbeep.com/uk/wp-content/uploads/2025/07/diffused-amylin-binder-UW-IPD-380x220.jpg)
AI Hits Disordered Proteins, Unlocks Therapy Targets
Drug developers have historically glued their attention to targeting the precise and fine-tuned protein structures underlying biological function.…