Distinct genetic architecture in the tails of complex traits
Data processingUKB genotype data The UKB is a prospective cohort study of approximately 500,000 participants recruited across the…
Sperm sequencing reveals extensive positive selection in the male germline
Ethics This study was carried out under TwinsUK BioBank ethics, approved by the North West–Liverpool Central Research Ethics…
Hotspots of human mutation point to clonal expansions in spermatogonia
Lawson, A. R. J. et al. Somatic mutation and selection at population scale. Nature https://doi.org/10.1038/s41586-025-09584-w (2025). Maeda, H.…
Biobank-scale genetic characterization of Alzheimer’s disease and related dementias across diverse ancestries
Large-scale genetic characterization nominates known and novel potential disease-causing variants associated with Alzheimer’s disease and related dementias We…