Safety and security of large language models in healthcare
Gommers, J. et al. Interval cancer, sensitivity, and specificity comparing AI-supported mammography screening with standard double reading without…
Health system learning enables generalist neuroimaging models
Health system learning We define ‘health system learning’ as learning directly from uncurated data generated during routine clinical…
Generative AI-enabled clinical decision support system in primary care: a pragmatic, cluster-randomized trial
Design We conducted a pragmatic, multicenter, parallel-group cluster-randomized controlled trial across a network of 16 primary care facilities…
Effects of exercise and liraglutide on vascular health and inflammation during weight loss maintenance: a prespecified secondary analysis of the S-LiTE trial
Study design This study is a secondary analysis of a randomized, placebo-controlled trial. The trial is registered with…
Towards autonomous medical artificial intelligence agents
MIMIC-IV datasetDataset description We develop a benchmark of 574 patients derived from the MIMIC-IV database which is a…
Spatial atlas of diabetic kidney disease reveals a B cell-rich subgroup
Sample acquisition and ethics approval The University of Pennsylvania institutional review board (IRB) approved the collection of human…
Safety and efficacy of intratumoural anti-CTLA4 with intravenous anti-PD1
Study sponsorship, authorizations and ethics This study was an investigator initiated trial sponsored by Gustave Roussy and covered…
AI framework for multidisease detection via retinal imaging
Study population For the model training, we used CFPs from the UKB and three hospital-based centers in China…
An LLM chatbot to facilitate primary-to-specialist care transitions: a randomized controlled trial
Ethics approval The Chinese Academy of Medical Sciences and Peking Union Medical College and the local medical ethics…
Molecular profiling of brain endothelial cell to astrocyte endfoot communication in mouse and human
Animals All experiments were conducted under the UK Home Office Animals (Scientific Procedures) Act 1986, in agreement with…
Reporter’s Notebook: The Overdue Breakout for Gene Therapy and Gene Editing
As gene editing enters a new era, leaders discuss Baby KJ’s implications for families, science, and industry. (Left…
Oxford Nanopore Announces PromethION Plus Flow Cell and Human Genetics Updates at ASHG 2025
OXFORD, England, October 15, 2025–(BUSINESS WIRE)–At the American Society of Human Genetics (ASHG) 2025 industry session on 16th…