{"id":220542,"date":"2025-10-23T15:13:08","date_gmt":"2025-10-23T15:13:08","guid":{"rendered":"https:\/\/www.newsbeep.com\/uk\/220542\/"},"modified":"2025-10-23T15:13:08","modified_gmt":"2025-10-23T15:13:08","slug":"scientists-found-a-way-to-turn-off-prostate-cancer-genes-baku-ws-news-site","status":"publish","type":"post","link":"https:\/\/www.newsbeep.com\/uk\/220542\/","title":{"rendered":"Scientists found a way to &#8220;turn off&#8221; prostate cancer genes | Baku.ws News Site"},"content":{"rendered":"<p>                            <img decoding=\"async\" src=\"https:\/\/www.newsbeep.com\/uk\/wp-content\/uploads\/2025\/10\/nCGtY5V9TM4XxuTS164GPhuiSPRhOuBoGZfGqAXc.webp.webp\" alt=\"Scientists found a way to turn off prostate cancer genes\" title=\"Scientists found a way to turn off prostate cancer genes\"\/><\/p>\n<p>                                23<br \/>\n                                Oct<\/p>\n<p>                                2025<br \/>\n                                18:56\n                            <\/p>\n<p>Researchers from the University of Michigan have developed a drug that can stop prostate cancer growth by blocking its genetic mechanisms. The results of the work are published in the journal Nature Genetics.<\/p>\n<p>The study showed that malignant prostate cells depend on special DNA regions &#8211; enhancers, which act as &#8220;switches&#8221; for tumor growth. Scientists discovered a key chemical mark of these enhancers &#8211; H2BNTac acetylation, as well as the enzymes p300 and CBP responsible for its activation.<\/p>\n<p>Based on this discovery, the team created the drug CBPD-409, which selectively destroys the p300 and CBP enzymes. By destroying them, the agent eliminates the H2BNTac mark and thereby suppresses the activity of androgen receptors &#8211; the main &#8220;drivers&#8221; of tumor growth.<\/p>\n<p>In experiments on cell cultures and animal models, the drug stopped the development of therapy-resistant forms of prostate cancer and caused tumor regression without noticeable side effects.<\/p>\n<p>According to the authors, this approach opens the way to a new type of therapy &#8211; targeted degradation of proteins that control malignant processes. Researchers believe that this method can form the basis for treating the most aggressive and drug-resistant forms of the disease.<\/p>\n","protected":false},"excerpt":{"rendered":"23 Oct 2025 18:56 Researchers from the University of Michigan have developed a drug that can stop prostate&hellip;\n","protected":false},"author":2,"featured_media":220543,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[25],"tags":[916,90,56,54,55],"class_list":{"0":"post-220542","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-genetics","8":"tag-genetics","9":"tag-science","10":"tag-uk","11":"tag-united-kingdom","12":"tag-unitedkingdom"},"_links":{"self":[{"href":"https:\/\/www.newsbeep.com\/uk\/wp-json\/wp\/v2\/posts\/220542","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.newsbeep.com\/uk\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.newsbeep.com\/uk\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/uk\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/uk\/wp-json\/wp\/v2\/comments?post=220542"}],"version-history":[{"count":0,"href":"https:\/\/www.newsbeep.com\/uk\/wp-json\/wp\/v2\/posts\/220542\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/uk\/wp-json\/wp\/v2\/media\/220543"}],"wp:attachment":[{"href":"https:\/\/www.newsbeep.com\/uk\/wp-json\/wp\/v2\/media?parent=220542"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.newsbeep.com\/uk\/wp-json\/wp\/v2\/categories?post=220542"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.newsbeep.com\/uk\/wp-json\/wp\/v2\/tags?post=220542"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}