Different fish oils reactions Researchers at the University of Helsinki<\/a> and the Wihuri Research Institute<\/a> gave 38 healthy adults large doses of EPA for four weeks. The goal was simple: see how EPA changes blood fats in people without heart disease. The results, however, were anything but simple.<\/p>\n \u201cThe samples taken during supplementation clearly show the effect of EPA on all participants. Having said that, all samples were different among the group. In other words, each individual has a unique lipoprotein lipidome in their circulation, a \u2018lipid fingerprint\u2019, if you will, that persisted despite EPA supplementation,\u201d said Professor Katariina \u00d6\u00f6rni.<\/p>\n Everyone\u2019s body reacted, but no two reactions matched. That unique \u201clipid<\/a> fingerprint\u201d stayed stable even as EPA flooded the bloodstream.<\/p>\n Fast effects that are short lasting<\/p>\n EPA levels shot up quickly. Within one week, blood concentrations multiplied several times. Then, just as fast, they dropped once the supplements stopped. People who started with the lowest EPA levels saw the biggest jumps.<\/p>\n Even short-term use changed how fats behaved in the blood. EPA improved lipid balance and reduced the stickiness of lipoproteins \u2013 the fat-carrying particles that can latch onto artery walls. That\u2019s important because once lipoproteins cling to arteries, they start forming dangerous plaques.<\/p>\n The study found that EPA didn\u2019t just float through the system. It reshaped it. Lipid profiles shifted toward fewer saturated and omega-6 fats and more omega-3s. That balance is linked with better heart health and lower inflammation.<\/p>\n Fish oils change energy<\/p>\n The changes went deeper than blood tests. Inside the body, metabolism began to pivot. Glucose levels rose slightly, while lactate and ketone bodies fell \u2013 clear signs that cells were relying more on oxygen-driven energy rather than short bursts of anaerobic power.<\/p>\n This switch fits what scientists know about EPA\u2019s influence on fat burning. The fatty acid activates certain genes that favor oxidation of fats and suppress fat creation. That shift helps the body clear triglycerides faster and lowers circulating fat<\/a> levels.<\/p>\n EPA also triggered a fall in two key inhibitors of fat metabolism \u2013 apoC-III and ANGPTL3. When these molecules drop, fat breakdown speeds up. The result is cleaner, less congested blood chemistry.<\/p>\n Changes in blood fats<\/p>\n High-dose EPA didn\u2019t just change how much fat was in the blood \u2013 it changed what kind of fat. Lipoproteins carrying harmful fats became less dense and less sticky. <\/p>\n LDL particles, often labeled \u201cbad cholesterol,\u201d contained fewer saturated lipids and more of EPA\u2019s unsaturated type. HDL particles, the \u201cgood\u201d ones, grew larger and richer in cholesterol, a feature linked with stronger artery protection.<\/p>\n EPA molecules also replaced inflammatory lipids in cell membranes. This swap affected how cells responded to stress and immune triggers. \u201cIt\u2019s interesting to see how, for instance, dietary changes affect lipoprotein quality, or the individual lipid fingerprint,\u201d \u00d6\u00f6rni notes.<\/p>\n EPA\u2019s influence didn\u2019t stop at metabolism. It disrupted inflammatory signals inside immune and vascular cells. <\/p>\n By competing with arachidonic acid, EPA pushed the body to make more calming compounds like resolvin E1. These molecules help tissues recover after inflammation and protect blood vessels from long-term damage.<\/p>\n Fish oils affect everyone differently<\/p>\n Not everyone saw the same benefits. Some participants\u2019 lipid profiles improved dramatically, while others changed only slightly. That variation points to the role of genetics, metabolism, and baseline health in shaping nutritional outcomes.<\/p>\n \u201cThe findings highlight the importance of metabolism in the prevention of cardiovascular diseases. EPA\u2019s effects varied more between individuals than we expected. We also demonstrated that these effects dissipate quickly, which is good to know in case EPA were to have adverse effects,\u201d said doctoral researcher Lauri \u00c4ik\u00e4s.<\/p>\n The quick rise and fall of EPA levels mean its effects are strong but temporary. If supplements stop, the benefits fade. Yet this fast turnover may also protect users from unwanted reactions.<\/p>\n One diet doesn\u2019t fit all<\/p>\n This study reinforces a simple truth: one diet does not fit all. EPA works, but how well it works depends on each person\u2019s unique metabolism. <\/p>\n The researchers now plan to test how EPA affects inflammatory cells and the molecules that control immune balance.<\/p>\n Their work shows that the body doesn\u2019t just absorb nutrients \u2013 it negotiates with them. Each person\u2019s chemistry writes its own version of health. And in that story, metabolism, not medicine, may be the quiet guardian of the heart.<\/p>\n The study is published in the journal JCI Insight<\/a>.<\/p>\n \u2014\u2013<\/p>\n Like what you read? Subscribe to our newsletter<\/a> for engaging articles, exclusive content, and the latest updates.\u00a0<\/p>\n Check us out on EarthSnap<\/a>, a free app brought to you by Eric Ralls<\/a> and Earth.com.<\/p>\n \u2014\u2013<\/p>\n","protected":false},"excerpt":{"rendered":"Fish oil has always had a good reputation. People take it hoping to keep their hearts strong, but…\n","protected":false},"author":2,"featured_media":223833,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[45],"tags":[102,6636,56,54,55],"class_list":{"0":"post-223832","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-nutrition","8":"tag-health","9":"tag-nutrition","10":"tag-uk","11":"tag-united-kingdom","12":"tag-unitedkingdom"},"_links":{"self":[{"href":"https:\/\/www.newsbeep.com\/uk\/wp-json\/wp\/v2\/posts\/223832","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.newsbeep.com\/uk\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.newsbeep.com\/uk\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/uk\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/uk\/wp-json\/wp\/v2\/comments?post=223832"}],"version-history":[{"count":0,"href":"https:\/\/www.newsbeep.com\/uk\/wp-json\/wp\/v2\/posts\/223832\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/uk\/wp-json\/wp\/v2\/media\/223833"}],"wp:attachment":[{"href":"https:\/\/www.newsbeep.com\/uk\/wp-json\/wp\/v2\/media?parent=223832"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.newsbeep.com\/uk\/wp-json\/wp\/v2\/categories?post=223832"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.newsbeep.com\/uk\/wp-json\/wp\/v2\/tags?post=223832"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
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