{"id":412151,"date":"2026-02-07T01:46:11","date_gmt":"2026-02-07T01:46:11","guid":{"rendered":"https:\/\/www.newsbeep.com\/uk\/412151\/"},"modified":"2026-02-07T01:46:11","modified_gmt":"2026-02-07T01:46:11","slug":"super-broadband-stimulated-raman-scattering-spectroscopy-and-imaging","status":"publish","type":"post","link":"https:\/\/www.newsbeep.com\/uk\/412151\/","title":{"rendered":"Super-broadband stimulated Raman scattering spectroscopy and imaging"},"content":{"rendered":"

Raman, C. V. & Krishnan, K. S. A new type of secondary radiation. Nature 121, 501\u2013502 (1928).<\/p>\n

Article<\/a>\u00a0
\n ADS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Movasaghi, Z., Rehman, S. & Rehman, I. U. Raman spectroscopy of biological tissues. Appl. Spectrosc. Rev. 42, 493\u2013541 (2007).<\/p>\n

Article<\/a>\u00a0
\n ADS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Rygula, A. et al. Raman spectroscopy of proteins: a review. J. Raman Spectrosc. 44, 1061\u20131076 (2013).<\/p>\n

Article<\/a>\u00a0
\n ADS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Czamara, K. et al. Raman spectroscopy of lipids: a review. J. Raman Spectrosc. 46, 4\u201320 (2015).<\/p>\n

Article<\/a>\u00a0
\n ADS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Lima, C., Muhamadali, H. & Goodacre, R. The role of Raman spectroscopy within quantitative metabolomics. Annu. Rev. Anal. Chem. 14, 323\u2013345 (2021).<\/p>\n

Article<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Cheng, J.-X. & Xie, X. S. Vibrational spectroscopic imaging of living systems: an emerging platform for biology and medicine. Science 350, eaaa8870 (2015).<\/p>\n

Article<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Nie, S. & Emory, S. R. Probing single molecules and single nanoparticles by surface-enhanced Raman scattering. Science 275, 1102\u20131106 (1997).<\/p>\n

Article<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Cheng, J.-X., Jia, Y. K., Zheng, G. & Xie, X. S. Laser-scanning coherent anti-Stokes Raman scattering microscopy and applications to cell biology. Biophys. J. 83, 502\u2013509 (2002).<\/p>\n

Article<\/a>\u00a0
\n ADS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Freudiger, C. W. et al. Label-free biomedical imaging with high sensitivity by stimulated Raman scattering microscopy. Science 322, 1857\u20131861 (2008).<\/p>\n

Article<\/a>\u00a0
\n ADS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Min, W., Freudiger, C. W., Lu, S. & Xie, X. S. Coherent nonlinear optical imaging: beyond fluorescence microscopy. Annu. Rev. Phys. Chem. 62, 507\u2013530 (2011).<\/p>\n

Article<\/a>\u00a0
\n ADS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Evans, C. L. et al. Chemical imaging of tissue in vivo with video-rate coherent anti-Stokes Raman scattering microscopy. Proc. Natl Acad. Sci. USA 102, 16807\u201316812 (2005).<\/p>\n

Article<\/a>\u00a0
\n ADS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Saar, B. G. et al. Video-rate molecular imaging in vivo with stimulated Raman scattering. Science 330, 1368\u20131370 (2010).<\/p>\n

Article<\/a>\u00a0
\n ADS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Dodo, K., Fujita, K. & Sodeoka, M. Raman spectroscopy for chemical biology research. J. Am. Chem. Soc. 144, 19651\u201319667 (2022).<\/p>\n

Article<\/a>\u00a0
\n ADS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Gao, X., Li, X. & Min, W. Absolute stimulated Raman cross sections of molecules. J. Phys. Chem. Lett. 14, 5701\u20135708 (2023).<\/p>\n

Article<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

De Silvestri, S. et al. Femtosecond time-resolved measurements of optic phonon dephasing by impulsive stimulated Raman scattering in \u03b1-perylene crystal from 20 to 300 K. Chem. Phys. Lett. 116, 146\u2013152 (1985).<\/p>\n

Article<\/a>\u00a0
\n ADS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Selm, R. et al. Ultrabroadband background-free coherent anti-Stokes Raman scattering microscopy based on a compact Er:fiber laser system. Opt. Lett. 35, 3282\u20133284 (2010).<\/p>\n

Article<\/a>\u00a0
\n ADS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Ideguchi, T. et al. Coherent Raman spectro-imaging with laser frequency combs. Nature 502, 355\u2013358 (2013).<\/p>\n

Article<\/a>\u00a0
\n ADS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Camp, C. H. Jr et al. High-speed coherent Raman fingerprint imaging of biological tissues. Nat. Photon. 8, 627\u2013634 (2014).<\/p>\n

Article<\/a>\u00a0
\n ADS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Yu, Q. et al. Transient stimulated Raman excited fluorescence spectroscopy. J. Am. Chem. Soc. 145, 7758\u20137762 (2023).<\/p>\n

Article<\/a>\u00a0
\n ADS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Yu, Q. et al. Transient stimulated Raman scattering spectroscopy and imaging. Light Sci. Appl. 13, 70 (2024).<\/p>\n

Article<\/a>\u00a0
\n ADS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Kop, R. H., De Vries, P., Sprik, R. & Lagendijk, A. Kramers-Kronig relations for an interferometer. Opt. Commun. 138, 118\u2013126 (1997).<\/p>\n

Article<\/a>\u00a0
\n ADS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Lenz, G., Eggleton, B., Giles, C., Madsen, C. & Slusher, R. Dispersive properties of optical filters for WDM systems. IEEE J. Quantum Electron. 34, 1390\u20131402 (1998).<\/p>\n

Article<\/a>\u00a0
\n ADS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Chia, S.-H. et al. Two-octave-spanning dispersion-controlled precision optics for sub-optical-cycle waveform synthesizers. Optica 1, 315\u2013322 (2014).<\/p>\n

Article<\/a>\u00a0
\n ADS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Prince, R. C., Frontiera, R. R. & Potma, E. O. Stimulated Raman scattering: from bulk to nano. Chem. Rev. 117, 5070\u20135094 (2016).<\/p>\n

Article<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Stolen, R. & Lin, C. Self-phase-modulation in silica optical fibers. Phys. Rev. A 17, 1448 (1978).<\/p>\n

Article<\/a>\u00a0
\n ADS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Tomlinson, W., Stolen, R. & Shank, C. Compression of optical pulses chirped by self-phase modulation in fibers. JOSA B 1, 139\u2013149 (1984).<\/p>\n

Article<\/a>\u00a0
\n ADS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Nakamura, T., Ramaiah Badarla, V., Hashimoto, K., Schunemann, P. G. & Ideguchi, T. Simple approach to broadband mid-infrared pulse generation with a mode-locked Yb-doped fiber laser. Opt. Lett. 47, 1790\u20131793 (2022).<\/p>\n

Article<\/a>\u00a0
\n ADS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Selm, R., Krauss, G., Leitenstorfer, A. & Zumbusch, A. Simultaneous second-harmonic generation, third-harmonic generation, and four-wave mixing microscopy with single sub-8 fs laser pulses. Appl. Phys. Lett. 99, 181124 (2011).<\/p>\n

Article<\/a>\u00a0
\n ADS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Xiong, H. et al. Stimulated Raman excited fluorescence spectroscopy and imaging. Nat. Photon. 13, 412\u2013417 (2019).<\/p>\n

Article<\/a>\u00a0
\n ADS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Palonpon, A. F. et al. Raman and SERS microscopy for molecular imaging of live cells. Nat. Protoc. 8, 677\u2013692 (2013).<\/p>\n

Article<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Yamakoshi, H. et al. Imaging of EdU, an alkyne-tagged cell proliferation probe, by Raman microscopy. J. Am. Chem. Soc. 133, 6102\u20136105 (2011).<\/p>\n

Article<\/a>\u00a0
\n ADS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Kuramochi, H., Takeuchi, S. & Tahara, T. Femtosecond time-resolved impulsive stimulated Raman spectroscopy using sub-7-fs pulses: apparatus and applications. Rev. Sci. Instrum. 87, 043107 (2016).<\/p>\n

Article<\/a>\u00a0
\n ADS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Paxinos, G. & Franklin, K. B. Paxinos and Franklin\u2019s the Mouse Brain in Stereotaxic Coordinates (Academic Press, 2019).<\/p>\n

Rohleder, D., Kiefer, W. & Petrich, W. Quantitative analysis of serum and serum ultrafiltrate by means of Raman spectroscopy. Analyst 129, 906\u2013911 (2004).<\/p>\n

Article<\/a>\u00a0
\n ADS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Saade, J. et al. Glicemical analysis of human blood serum using FT-Raman: a new approach. Photomed. Laser Surg. 30, 388\u2013392 (2012).<\/p>\n

Article<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Giansante, S., Giana, H. E., Fernandes, A. B. & Silveira, L. Jr Analytical performance of Raman spectroscopy in assaying biochemical components in human serum. Lasers Med. Sci. 37, 287\u2013298 (2022).<\/p>\n

Article<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Medipally, D. K. et al. Development of a high throughput (HT) Raman spectroscopy method for rapid screening of liquid blood plasma from prostate cancer patients. Analyst 142, 1216\u20131226 (2017).<\/p>\n

Article<\/a>\u00a0
\n ADS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Friedman, A. N. & Fadem, S. Z. Reassessment of albumin as a nutritional marker in kidney disease. J. Am. Soc. Nephrol. 21, 223\u2013230 (2010).<\/p>\n

Article<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Alves-Bezerra, M. & Cohen, D. E. Triglyceride metabolism in the liver. Compr. Physiol. 8, 1\u201322 (2018).<\/p>\n

Article<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Kannel, W. B., Castelli, W. P. & Gordon, T. Cholesterol in the prediction of atherosclerotic disease: new perspectives based on the Framingham study. Ann. Intern. Med. 90, 85\u201391 (1979).<\/p>\n

Article<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Don, B. R. & Kaysen, G. Poor nutritional status and inflammation: serum albumin: relationship to inflammation and nutrition. Semin. Dial. 17, 432\u2013437 (2004).<\/p>\n

Article<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Busher, J. T. in Clinical Methods: The History, Physical, and Laboratory Examinations (eds Walker, H. K. et al.) Ch. 101 (Butterworths, 1990).<\/p>\n

Cheng, J.-X. & Xie, X. S. Coherent Raman Scattering Microscopy (CRC Press, 2012).<\/p>\n

Camp, C. H. Jr, Lee, Y. J. & Cicerone, M. T. Quantitative, comparable coherent anti-Stokes Raman scattering (CARS) spectroscopy: correcting errors in phase retrieval. J. Raman Spectrosc. 47, 408\u2013415 (2016).<\/p>\n

Article<\/a>\u00a0
\n ADS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Pollard, W. T. & Mathies, R. A. Analysis of femtosecond dynamic absorption spectra of nonstationary states. Annu. Rev. Phys. Chem. 43, 497\u2013523 (1992).<\/p>\n

Article<\/a>\u00a0
\n ADS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Kuramochi, H. & Tahara, T. Tracking ultrafast structural dynamics by time-domain Raman spectroscopy. J. Am. Chem. Soc. 143, 9699\u20139717 (2021).<\/p>\n

Article<\/a>\u00a0
\n ADS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Topol, E. J. High-performance medicine: the convergence of human and artificial intelligence. Nat. Med. 25, 44\u201356 (2019).<\/p>\n

Article<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Liu, X., Shi, L., Zhao, Z., Shu, J. & Min, W. VIBRANT: spectral profiling for single-cell drug responses. Nat. Methods 21, 501\u2013511 (2024).<\/p>\n

Article<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Liu, Y., Lee, Y. J. & Cicerone, M. T. Broadband CARS spectral phase retrieval using a time-domain Kramers\u2013Kronig transform. Opt. Lett. 34, 1363\u20131365 (2009).<\/p>\n

Article<\/a>\u00a0
\n ADS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Vartiainen, E. M., Rinia, H. A., M\u00fcller, M. & Bonn, M. Direct extraction of Raman line-shapes from congested CARS spectra. Opt. Express 14, 3622\u20133630 (2006).<\/p>\n

Article<\/a>\u00a0
\n ADS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Xiong, H. et al. Super-broadband stimulated Raman scattering spectroscopy and imaging. figshare https:\/\/doi.org\/10.6084\/m9.figshare.30379255<\/a> (2025).<\/p>\n","protected":false},"excerpt":{"rendered":"Raman, C. V. & Krishnan, K. S. A new type of secondary radiation. Nature 121, 501\u2013502 (1928). Article\u00a0…\n","protected":false},"author":2,"featured_media":412152,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[24],"tags":[18071,3250,2302,4418,33169,90,56,54,55],"class_list":{"0":"post-412151","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-physics","8":"tag-applied-and-technical-physics","9":"tag-general","10":"tag-physics","11":"tag-quantum-physics","12":"tag-raman-spectroscopy","13":"tag-science","14":"tag-uk","15":"tag-united-kingdom","16":"tag-unitedkingdom"},"_links":{"self":[{"href":"https:\/\/www.newsbeep.com\/uk\/wp-json\/wp\/v2\/posts\/412151","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.newsbeep.com\/uk\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.newsbeep.com\/uk\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/uk\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/uk\/wp-json\/wp\/v2\/comments?post=412151"}],"version-history":[{"count":0,"href":"https:\/\/www.newsbeep.com\/uk\/wp-json\/wp\/v2\/posts\/412151\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/uk\/wp-json\/wp\/v2\/media\/412152"}],"wp:attachment":[{"href":"https:\/\/www.newsbeep.com\/uk\/wp-json\/wp\/v2\/media?parent=412151"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.newsbeep.com\/uk\/wp-json\/wp\/v2\/categories?post=412151"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.newsbeep.com\/uk\/wp-json\/wp\/v2\/tags?post=412151"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}