GSK has revealed positive results for a treatment for gynaecological cancers as its chief executive, Luke Miels, seeks to speed up drug development at the group.<\/p>\n
The company said that in an early-stage trial Mocertatug Rezetecan, known as Mo-Rez, shrank or eliminated tumours in 62% of patients with ovarian cancer where chemotherapy had failed, and in 67% of those with endometrial cancer.<\/p>\n
Based in London, GSK has recently gained plaudits for its work on tackling superbugs<\/a>, becoming one of just three big pharma companies globally that continue to invest in anti-microbial research.<\/p>\n However, commercially GSK has been eclipsed in recent years by its bigger British rival AstraZeneca<\/a>, which last year outstripped GSK\u2019s near-\u00a333bn turnover by more than \u00a310bn and whose market value is more than twice as high.<\/p>\n GSK acquired the Mo-Rez cancer treatment, an antibody-drug conjugate (ADC), from China\u2019s Hansoh Pharma in late 2023, and has trialled it in 224 patients around the world, including the UK, over the past year. Only a few patients needed to stop treatment because of side-effects, the most common being nausea. It is administered every three weeks via intravenous infusion.<\/p>\n Luke Miels has announced several deals since taking the helm at GSK on 1 January. Photograph: GSK\/Reuters<\/p>\n Combined with data from a separate, intermediate trial in China, these results give the British drugmaker the confidence to go straight to late-stage trials, with five clinical studies planned globally in the next few months, including on patients in the UK.<\/p>\n Presenting the results at the Society of Gynecologic Oncology\u2019s annual meeting on women\u2019s cancer in Puerto Rico, Hesham Abdullah, GSK\u2019s global head of cancer research and development, said: \u201cTreatment of gynaecological cancers remains a major challenge, with a pressing need for new therapies that offer improved response rates. With Mo-Rez we now have compelling evidence of a promising clinical profile.\u201d<\/p>\n Endometrial cancer affects 1.6 million women globally, with 417,000 new cases each year. Ovarian cancer affects 843,000 people, with 240,000 new cases annually.<\/p>\n Speaking to journalists before the conference, Abdullah described Mo-Rez as a \u201ckey asset\u201d in the company\u2019s growing cancer portfolio. It is expected to be a blockbuster drug, with peak annual sales of more than \u00a32bn, which GSK hopes will help it to achieve its 2031 sales target of \u00a340bn.<\/p>\n Miels, an Australian<\/a> who was brought in by his predecessor, Emma Walmsley, from AstraZeneca in 2017 and worked for Roche and Sanofi-Aventis, has announced several deals since taking the helm at GSK on 1 January, and vowed to show \u201cscientific courage\u201d<\/a>.<\/p>\n Abdullah said Miels, with whom he previously worked at AstraZeneca, had stepped up the pace of drug development. \u201cThe entire organisation is certainly really enjoying following this pace, the agility, and having the scientific courage.<\/p>\n \u201cHis leadership style, the engagement, the strategic insight, the drug development expertise \u2026 you\u2019re also seeing some of that come to life through the development programmes.\u201d<\/p>\n