{"id":532785,"date":"2026-04-15T19:47:11","date_gmt":"2026-04-15T19:47:11","guid":{"rendered":"https:\/\/www.newsbeep.com\/uk\/532785\/"},"modified":"2026-04-15T19:47:11","modified_gmt":"2026-04-15T19:47:11","slug":"new-nasal-spray-appears-to-reverse-brain-ageing-in-weeks","status":"publish","type":"post","link":"https:\/\/www.newsbeep.com\/uk\/532785\/","title":{"rendered":"New Nasal Spray Appears To Reverse Brain Ageing In ‘Weeks’"},"content":{"rendered":"

A nasal spray has been found to reverse signs of brain ageing in preclinical trials, according to a new paper published in the Journal of Extracellular Vesicles<\/a>.<\/p>\n

The spray, which tackles a process typical to ageing brains called \u201cneuroinflammaging\u201d, delivered benefits within weeks \u2013 and results lasted for months. <\/p>\n

\u201cWhat we\u2019re showing is brain ageing can be reversed, to help people stay mentally sharp, socially engaged and free from age-related decline,\u201d research author Dr Ashok K. Shetty told Texas A&M University<\/a>.<\/p>\n

He added that this may be especially important as \u201cbrain age-related diseases like dementia are a major health concern worldwide\u201d. <\/p>\n

Two doses of the spray seemed to help <\/p>\n

The spray aims to change how carriers of genetic material called extracellular vesicles (EVs) can reach the brain. EVS contain microRNAs.<\/p>\n

\u201cMicroRNAs act like master regulators,\u201d nasal spray researcher Dr Madhu Leelavathi Narayana said.<\/a> \u201cThey help modulate and regulate many gene and signalling pathways in the brain.\u201d<\/p>\n

The aim of the new nasal spray is to break through the brain\u2019s defences to deliver these useful bundles of genetic information straight to people\u2019s minds. <\/p>\n

That way, the brain absorbs more microRNAs, which help to \u201crecharge\u201d the brain cells of those using the spray. <\/p>\n

In the study, that led to less brain fog, better ability to process and remember information, and less inflammation (chronic inflammation<\/a> is linked to increased signs of ageing). <\/p>\n

\u201cWe are giving neurons their spark back by reducing oxidative stress and reactivating the brain\u2019s mitochondria,\u201d said Dr Naryana.<\/p>\n

And Dr Shetty added <\/a>they saw the \u201cbrain\u2019s own repair systems switch on, healing inflammation and restoring itself\u201d.<\/p>\n

More research is still needed <\/p>\n

These were promising preclinical results, but scientists will need a lot more research to develop this spray. <\/p>\n

\u201cThis kind of work requires resources and the right people to tackle problems and develop solutions that could change lives,\u201d said Dr Shetty<\/a>.<\/p>\n

But, he said: \u201cAs we develop and scale this therapy, a simple, two-dose nasal spray could one day replace invasive, risky procedures or maybe even months of medication.\u201d <\/p>\n","protected":false},"excerpt":{"rendered":"A nasal spray has been found to reverse signs of brain ageing in preclinical trials, according to a…\n","protected":false},"author":2,"featured_media":532786,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[42],"tags":[5079,854,102,6591,90,56,54,55],"class_list":["post-532785","post","type-post","status-publish","format-standard","has-post-thumbnail","category-medication","tag-ageing","tag-dementia","tag-health","tag-medication","tag-science","tag-uk","tag-united-kingdom","tag-unitedkingdom"],"_links":{"self":[{"href":"https:\/\/www.newsbeep.com\/uk\/wp-json\/wp\/v2\/posts\/532785","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.newsbeep.com\/uk\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.newsbeep.com\/uk\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/uk\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/uk\/wp-json\/wp\/v2\/comments?post=532785"}],"version-history":[{"count":0,"href":"https:\/\/www.newsbeep.com\/uk\/wp-json\/wp\/v2\/posts\/532785\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/uk\/wp-json\/wp\/v2\/media\/532786"}],"wp:attachment":[{"href":"https:\/\/www.newsbeep.com\/uk\/wp-json\/wp\/v2\/media?parent=532785"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.newsbeep.com\/uk\/wp-json\/wp\/v2\/categories?post=532785"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.newsbeep.com\/uk\/wp-json\/wp\/v2\/tags?post=532785"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}