{"id":592549,"date":"2026-05-19T13:52:14","date_gmt":"2026-05-19T13:52:14","guid":{"rendered":"https:\/\/www.newsbeep.com\/uk\/592549\/"},"modified":"2026-05-19T13:52:14","modified_gmt":"2026-05-19T13:52:14","slug":"scientists-uncover-promising-new-strategy-to-stop-parkinsons-in-its-tracks","status":"publish","type":"post","link":"https:\/\/www.newsbeep.com\/uk\/592549\/","title":{"rendered":"Scientists Uncover Promising New Strategy To Stop Parkinson\u2019s in Its Tracks"},"content":{"rendered":"

\"Human<\/a>Researchers at the University of Pennsylvania have identified a protein that may play a central role in how Parkinson\u2019s disease spreads through the brain. Their findings suggest that blocking this immune-related protein with specially designed antibodies could interrupt a damaging cycle linked to the progression of the disease. Credit: Shutterstock<\/p>\n

A newly identified immune-related protein may help drive the spread of Parkinson\u2019s disease in the brain.<\/p>\n

A protein tied to the brain\u2019s immune system may be helping Parkinson\u2019s disease spread from cell to cell, and scientists believe stopping it could open a new path toward slowing the disease itself.<\/p>\n

In a new study published in Neuron, researchers at the Perelman School of Medicine at the University of Pennsylvania<\/a> reported that monoclonal antibodies were able to block the activity of a protein called glycoprotein nonmetastatic melanoma B (GPNMB), preventing the spread of harmful Parkinson\u2019s-related protein clumps in laboratory experiments.<\/p>\n

\u201cMany patients with Parkinson\u2019s disease are diagnosed in the early stages, when symptoms are relatively mild, but there is currently no treatment that slows the progression,\u201d said lead author, Alice Chen\u2011Plotkin, MD, Parker Family Professor of Neurology. \u201cThese early results are a promising step towards developing this type of treatment.\u201d<\/p>\n

Understanding Parkinson\u2019s Disease Progression<\/p>\n

More than one million people in the United States are living with PD, and about 90,000 new cases are diagnosed each year. Although researchers still do not fully understand what causes the disease, scientists know it spreads through the brain over time.<\/p>\n

The process is linked to abnormal buildups of alpha-synuclein, a protein found in neurons. These protein clumps collect inside brain cells, damaging and eventually killing them. The abnormal proteins can then move into nearby healthy neurons, allowing the disease to spread into additional brain regions. As this progression continues, symptoms such as tremors and trouble walking or swallowing become more severe.<\/p>\n

Current treatments can help manage symptoms, including medications such as levodopa and procedures like deep-brain stimulation using implanted electrodes. However, none of these approaches can stop or slow the underlying progression of Parkinson\u2019s disease.<\/p>\n

GPNMB Emerges as a Therapeutic Target<\/p>\n

In earlier research published in 2022<\/a>, Chen-Plotkin and her colleagues identified GPNMB as an important factor involved in the spread of alpha-synuclein between neurons. That discovery pointed to the protein as a possible therapeutic target.<\/p>\n

In the new study, the researchers found that microglia, the immune cells that help protect the brain, produce large amounts of GPNMB in Parkinson\u2019s disease. When these cells encounter injured or dying neurons, GPNMB production increases. Enzymes then cut the protein from the cell surface, allowing it to move between cells.<\/p>\n

Experiments using cultured neurons showed that antibodies designed to block GPNMB reduced the spread of alpha-synuclein pathology from one cell to another.<\/p>\n

\u201cThese results suggest Parkinson\u2019s disease may be driven by a self-reinforcing cycle\u2014alpha-synuclein accumulates in neurons, damaging the neurons. The injury to the neurons initiates the release of GPNMB, which accelerates the spread of alpha-synuclein, leading to further damage,\u201d Chen-Plotkin said. \u201cInterrupting this cycle would hopefully slow, or even stop, the spread of alpha-synuclein through the brain and the neurodegeneration that follows.\u201d<\/p>\n

Evidence From Human Brain Tissue<\/p>\n

To see whether the findings also applied to humans, the researchers examined tissue from 1,675 brains stored in the Penn Brain Bank<\/a>. People with genetic variants linked to increased GPNMB production also showed more widespread alpha-synuclein pathology, strengthening evidence that the protein plays a major role in disease progression.<\/p>\n

The team also found that higher GPNMB levels were not associated with markers tied to other neurodegenerative disorders such as Alzheimer\u2019s disease.<\/p>\n

\u201cThese results are promising for laboratory models and human brain tissue analysis, but we still have a lot of work to do before we can translate this therapy into humans,\u201d said Chen-Plotkin. \u201cThat being said, these results are encouraging as we continue to work towards a novel treatment for PD.\u201d<\/p>\n

Reference: \u201cSecreted GPNMB enhances uptake of fibrillar alpha-synuclein in a non-cell-autonomous process that can be blocked by anti-GPNMB antibodies\u201d by Marc Carceles-Cordon, Eliza M. Brody, Masen L. Boucher, Michael D. Gallagher, Robert T. Skrinak, Travis L. Unger, Cooper K. Penner, Adama J. Berndt, Sromona Das, Katie Lam, Rudolf Jaenisch, Vivianna Van Deerlin, Edward B. Lee, Kurt Brunden, Kelvin C. Luk and Alice S. Chen-Plotkin, 12 May 2026, Neuron.
DOI: 10.1016\/j.neuron.2026.04.033<\/a><\/p>\n

This study was supported by the National Institutes of Health (R37 NS115139, P30 AG010124, U19 AG062418, P01 AG084497), SPARK\u2011NS, the Parker Family Chair, and the Lipman Family Fund.<\/p>\n

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Follow us on Google<\/a> and Google News<\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"Researchers at the University of Pennsylvania have identified a protein that may play a central role in how…\n","protected":false},"author":2,"featured_media":592550,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[10],"tags":[7341,15378,59,102,16042,917,1701,56,54,55,54435],"class_list":["post-592549","post","type-post","status-publish","format-standard","has-post-thumbnail","category-health","tag-brain","tag-cell-biology","tag-gb","tag-health","tag-immunology","tag-neurology","tag-parkinsons-disease","tag-uk","tag-united-kingdom","tag-unitedkingdom","tag-university-of-pennsylvania"],"_links":{"self":[{"href":"https:\/\/www.newsbeep.com\/uk\/wp-json\/wp\/v2\/posts\/592549","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.newsbeep.com\/uk\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.newsbeep.com\/uk\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/uk\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/uk\/wp-json\/wp\/v2\/comments?post=592549"}],"version-history":[{"count":0,"href":"https:\/\/www.newsbeep.com\/uk\/wp-json\/wp\/v2\/posts\/592549\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/uk\/wp-json\/wp\/v2\/media\/592550"}],"wp:attachment":[{"href":"https:\/\/www.newsbeep.com\/uk\/wp-json\/wp\/v2\/media?parent=592549"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.newsbeep.com\/uk\/wp-json\/wp\/v2\/categories?post=592549"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.newsbeep.com\/uk\/wp-json\/wp\/v2\/tags?post=592549"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}