The UK\u2019s first GLP-1 receptor agonist tablet for weight loss and weight management has today (11 June 2026) been approved by the Medicines and Healthcare products Regulatory Agency (MHRA).<\/p>\n
Alongside a reduced-calorie diet and increased physical activity, the semaglutide (Wegovy) tablet may now be prescribed to adults in the UK with obesity, who have a Body Mass Index (BMI) of 30 or above, or who are overweight with a BMI between 27 and 30 and at least one weight-related comorbidity.<\/p>\n
The starting dose for the semaglutide tablet is 1.5\u00a0mg once daily, increasing to 4\u00a0mg, 9\u00a0mg and 25\u00a0mg with a minimum duration of one month at each dose level.<\/p>\n
Patients currently treated privately with a 2.4\u00a0mg semaglutide injection once\u00a0weekly can be transitioned straight to semaglutide 25 mg tablets once daily.<\/p>\n
Julian Beach, Executive Director of Healthcare Quality and Access at the MHRA, said:<\/p>\n
\u201cHaving met the MHRA\u2019s rigorous standards of safety, quality and effectiveness, the semaglutide tablet has been approved in the UK for weight loss and weight management.\u00a0<\/p>\n
\u201cAs with all GLP-1 receptor agonists, this is a prescription-only medication.\u201d<\/p>\n
It is important to follow the instructions in the Patient Information Leaflet on how to take semaglutide tablets for weight loss and weight management treatment to be most effective. The semaglutide tablet should be taken whole on an empty stomach after fasting for at least 8 hours with a sip of water. After taking it, no food or drink should be taken for at least thirty minutes.\u00a0 Eating or drinking less than 30 minutes after taking a semaglutide tablet lowers its absorption.<\/p>\n
Semaglutide is a GLP-1 receptor agonist. It works by mimicking the action of a naturally occurring hormone, glucagon-like peptide (GLP-1), which is released by the body after eating. Semaglutide acts on areas of the brain that regulate appetite, helping people feel fuller for longer, reducing hunger and decreasing food cravings. As a result, it can help people eat less and support weight reduction alongside appropriate diet and lifestyle measures.<\/p>\n
Whilst this tablet is approved for use in the UK, it is not available currently via the NHS. As with all new treatments, decisions on NHS use will follow established processes, including an evaluation by the National Institute for Health and Care Excellence (NICE).<\/p>\n
The most common side effects of the medicine are gastrointestinal disorders including nausea, diarrhoea, constipation and vomiting.<\/p>\n
As with any medicine, the MHRA keeps the safety and effectiveness of semaglutide under close review.<\/p>\n
Anyone who suspects they are having a side effect from this medicine should talk to their doctor, pharmacist or nurse and report it directly to the MHRA Yellow Card scheme, either through the\u00a0website<\/a>\u00a0or by searching the Google Play or Apple App stores for MHRA Yellow Card.<\/p>\n Notes to editors<\/p>\n Authorisation for this new indication for the semaglutide (Wegovy) tablet was granted on 11 June 2026 to Novo Nordisk.<\/p>\n More information can be found in the Summary of Product Characteristics and Patient Information leaflets which will be published on the\u00a0MHRA Products website<\/a>\u00a0within 7 days of approval.<\/p>\n The Medicines and Healthcare products Regulatory Agency (MHRA) is responsible for regulating all medicines and medical devices in the UK by ensuring they work and are acceptably safe.\u00a0 All our work is underpinned by robust and fact-based judgements to ensure that the benefits justify any risks.<\/p>\n The MHRA is an executive agency of the Department of Health and Social Care.<\/p>\n