This article was reviewed by Darragh O\u2019Carroll, MD.<\/p>\n
Oral vs. Injectable Semaglutide: Effectiveness & Side Effects<\/p>\n
Key takeaways:<\/p>\n
You can get semaglutide injections (Ozempic\u00ae and Wegovy\u00ae) and oral semaglutide (Rybelsus\u00ae).<\/p>\n
Injections are usually more effective for weight loss than pills.<\/p>\n
If you don\u2019t like needles, Rybelsus\u00ae could be a good option. There are also other oral weight loss medications.<\/p>\n
Semaglutide (Ozempic\u00ae, Wegovy\u00ae, Rybelsus\u00ae) comes in both injection and oral form. But beyond how you take it, what\u2019s the difference? And which form is more effective for weight loss?<\/p>\n
Semaglutide injections and semaglutide pills work in similar ways, but injections are usually more effective for weight loss than pills.<\/p>\n
We\u2019ll explore oral vs. injectable semaglutide in more detail to help you figure out the right option for you.<\/p>\n
Oral vs. Injectable Semaglutide: An Overview<\/p>\n
So far, the Food and Drug Administration (FDA) has approved three semaglutide medications. Those include:<\/p>\n
Ozempic\u00ae<\/p>\n
Wegovy\u00ae<\/p>\n
Rybelsus\u00ae<\/p>\n
You can also get compounded semaglutide injections.<\/p>\n
Let\u2019s take a closer look at these oral and injectable forms of semaglutide.<\/p>\n
Ozempic\u00ae<\/p>\n
Ozempic\u00ae<\/p>\n
is FDA-approved to help people with type 2 diabetes control their blood sugar. It\u2019s sometimes prescribed off-label for weight loss in people with overweight and obesity.<\/p>\n
It\u2019s a once-a-week injection you take alongside making lifestyle changes, like <\/p>\n
eating more whole foods<\/p>\n
and doing more daily movement.<\/p>\n
As well as type 2 diabetes, Ozempic\u00ae is FDA-approved to <\/p>\n
reduce<\/p>\n
the risk of major cardiovascular events \u2014 like stroke and heart attack \u2014 in people with type 2 diabetes and cardiovascular disease.<\/p>\n
It\u2019s also approved to reduce cardiovascular death and kidney risks in those with <\/p>\n
type 2 diabetes<\/p>\n
and chronic kidney disease.<\/p>\n
Wegovy\u00ae<\/p>\n
Wegovy\u00ae is also a once-a-week injection. It contains a higher dose of semaglutide than Ozempic\u00ae, and it\u2019s currently the only semaglutide medication FDA-approved for weight loss.<\/p>\n
This drug is <\/p>\n
FDA-approved<\/p>\n
for weight reduction and chronic weight management alongside diet and exercise changes. It\u2019s for people with obesity or overweight with at least one weight-related health condition, like:<\/p>\n
High blood pressure (hypertension)<\/p>\n
High cholesterol (<\/p>\n
dyslipidemia<\/p>\n
)<\/p>\n
Type 2 diabetes<\/p>\n
Sleep apnea<\/p>\n
Wegovy\u00ae is also approved to reduce cardiovascular risks in those with cardiovascular disease and either obesity or overweight. It can also be prescribed to treat a type of fatty liver disease called noncirrhotic metabolic dysfunction-associated steatohepatitis (MASH).<\/p>\n
Rybelsus\u00ae<\/p>\n
Rybelsus\u00ae is a daily semaglutide pill. Alongside eating more nutritious foods and doing more movement, it\u2019s prescribed for people with type 2 diabetes to help manage their blood sugar.<\/p>\n
Like Ozempic\u00ae, healthcare professionals sometimes prescribe Rybelsus\u00ae off-label for weight loss when appropriate.<\/p>\n
Compounded Semaglutide<\/p>\n
Compounded semaglutide<\/p>\n
is a weekly injection that contains the active ingredient semaglutide. Healthcare providers prescribe it when people have a unique need, like needing a personalized dosing schedule.*<\/p>\n
*Compounded semaglutide is a compounded product and hasn\u2019t been approved by the FDA. The FDA doesn\u2019t review compounded products for safety, effectiveness, or quality.<\/p>\n
Is Oral Semaglutide as Effective as Injectable Semaglutide?<\/p>\n
Oral semaglutide may not be as effective as injectable semaglutide. Both formulations of semaglutide can help promote weight loss, but semaglutide injections can lead to more weight loss than oral semaglutide.<\/p>\n
Research on Oral vs. Injectable Semaglutide<\/p>\n
Research<\/p>\n
from 2021 looked at people with type 2 diabetes who made diet and exercise changes and took either 1 mg (milligram) of Ozempic\u00ae or 14 mg of Rybelsus\u00ae.<\/p>\n
Here\u2019s what the results found:<\/p>\n
People taking Ozempic\u00ae lost about 10 pounds.<\/p>\n
People taking Rybelsus\u00ae lost roughly 8 pounds.<\/p>\n
Wegovy\u00ae contains a higher dose of semaglutide than Ozempic\u00ae and may be even more effective for weight loss.<\/p>\n
One <\/p>\n
Wegovy\u00ae study<\/p>\n
found that those taking a 2.4-mg dose lost an average of around 15 percent of their body weight over 68 weeks.<\/p>\n
Results are similar out in the real world.<\/p>\n
\u201cIn my experience, patients taking injectable semaglutide typically lose more weight than those on oral semaglutide,\u201d says <\/p>\n
Craig Primack, MD<\/p>\n
, a physician specializing in obesity medicine and senior vice president of weight management at Hims & Hers.<\/p>\n
The reason for this, Dr. Primack explains, \u201cis because the dose of the injectable form achieves higher blood levels and, therefore, better appetite control.\u201c<\/p>\n
Oral Semaglutide vs. Injectable Semaglutide: Side Effects<\/p>\n
The side effects of oral semaglutide and semaglutide injections are mostly the same.<\/p>\n
Semaglutide side effects include:<\/p>\n
Nausea<\/p>\n
Vomiting<\/p>\n
Diarrhea<\/p>\n
Constipation<\/p>\n
Stomach pain<\/p>\n
You may feel side effects when you first start taking semaglutide and when your dose increases. But you should start feeling better <\/p>\n
with time<\/p>\n
as your body adjusts.<\/p>\n
Besides having similar side effects, both oral and injectable semaglutide may cause side effects for a similar number of people \u2014 although research is mixed.<\/p>\n
A <\/p>\n
2024 study<\/p>\n
on people with type 2 diabetes compared Ozempic\u00ae with Rybelsus\u00ae. The number of people who experienced side effects was similar.<\/p>\n
However, another <\/p>\n
study<\/p>\n
from 2024 on people with type 2 diabetes found that side effects were more common in people taking oral semaglutide than semaglutide injections.<\/p>\n
How Do You Take Oral Semaglutide?<\/p>\n
You take oral semaglutide once a day by mouth. There are a few other important points to know about taking this medication.<\/p>\n
Here\u2019s <\/p>\n
how<\/p>\n
you take Rybelsus\u00ae:<\/p>\n
Take Rybelsus\u00ae in the morning, at least 30 minutes before any food, drinks, or other oral medications or supplements.<\/p>\n
Take it with no more than 4 ounces of plain water.<\/p>\n
Swallow the tablet whole \u2014 don\u2019t crush, chew, or split it.<\/p>\n
Your prescribing healthcare provider can give you any further instructions you need to follow.<\/p>\n
How Do You Take Injectable Semaglutide?<\/p>\n
To take injectable semaglutide, you\u2019ll give yourself a shot once a week. Ideally, you\u2019ll do this on the same day each week. But you can inject it at any time, with or without food.<\/p>\n
Semaglutide is a subcutaneous injection, meaning you inject the medication just under your skin \u2014 not into a vein or muscle. You\u2019ll use a tiny needle that many people don\u2019t even feel.<\/p>\n
You can inject semaglutide <\/p>\n
into<\/p>\n
your:<\/p>\n
Stomach<\/p>\n
Thigh<\/p>\n
Upper arm<\/p>\n
Rotate your injection site each week. You can inject into the same area, but not the exact same spot.<\/p>\n
Need to change your injection day? You can do this as long as you gave yourself your last injection at least two days before. Check with your provider to be sure.<\/p>\n
Your healthcare provider can also explain how to give yourself a semaglutide injection. It can sound daunting, but once you get the hang of it, it\u2019s quick, easy, and pretty painless.<\/p>\n
Are More Oral Semaglutide Products on the Horizon?<\/p>\n
Currently, Rybelsus\u00ae is the only oral form of semaglutide, but more oral semaglutide medications could hit the market in the future.<\/p>\n
Novo Nordisk (the manufacturer of Ozempic\u00ae, Wegovy\u00ae, and Rybelsus\u00ae) is studying a high-dose oral form of semaglutide for weight loss.<\/p>\n
Clinical trials<\/p>\n
found that people taking 50 mg of oral semaglutide lost an average of 17.4 percent of their body weight in 68 weeks.<\/p>\n
More research is needed to check safety and efficacy.<\/p>\n
Other Oral Weight Loss Medications<\/p>\n
Beyond oral semaglutide, other oral medications can promote weight loss.<\/p>\n
\u00a0Kits combine oral medications in a formulation that best suits your body and needs.<\/p>\n
Kits can include:<\/p>\n
Bupropion.<\/p>\n
Bupropion is an antidepressant that healthcare providers sometimes <\/p>\n
prescribe<\/p>\n
with other medications to promote weight loss.<\/p>\n
Metformin.<\/p>\n
Metformin<\/p>\n
is a diabetes drug that\u2019s used off-label for weight loss. It can reduce appetite and change the gut microbiome to support weight loss.<\/p>\n
Naltrexone.<\/p>\n
Naltrexone can <\/p>\n
treat<\/p>\n
alcohol use disorder and opioid dependence. Providers sometimes prescribe it as part of a broader weight loss treatment plan.<\/p>\n
Topiramate.<\/p>\n
Topiramate<\/p>\n
is an epilepsy drug. It can also reduce appetite and change food-related reward pathways.<\/p>\n
Some kits also come with vitamin B12, an essential nutrient.<\/p>\n
Oral vs. Injectable Semaglutide: Which Form of Semaglutide Is Best?<\/p>\n
Both oral and injectable semaglutide can help you achieve your weight loss goals. But the best medication for you depends on a whole host of factors.<\/p>\n
Here\u2019s what to know:<\/p>\n
Ozempic\u00ae and Wegovy\u00ae are semaglutide injections, whereas Rybelsus\u00ae is a semaglutide pill.<\/p>\n
All forms of semaglutide can help you lose weight, but semaglutide injections are generally more effective than semaglutide pills.<\/p>\n
The best form of semaglutide for you depends on your health conditions, your feelings about needs, and whether you\u2019d prefer a daily or weekly treatment. Cost and availability might also come into play.<\/p>\n
A healthcare provider can help you decide between oral vs. injectable semaglutide \u2014 as well as semaglutide vs. other weight loss drugs, like metformin and topiramate.<\/p>\n
FAQs<\/p>\n
Check out answers to frequently asked questions about oral vs. injectable semaglutide.<\/p>\n
What is semaglutide and what does it do?<\/p>\n
Semaglutide is a glucagon-like peptide-1 receptor agonist, or <\/p>\n
GLP-1<\/p>\n
. It\u2019s FDA-approved for type 2 diabetes under the brand names Ozempic\u00ae and Rybelsus\u00ae. Under the brand name Wegovy\u00ae, it\u2019s FDA-approved for weight loss in people with overweight and obesity.<\/p>\n
For weight loss, Wegovy\u00ae <\/p>\n
works<\/p>\n
by reducing hunger, making you feel fuller, and curbing food cravings. These effects can help you eat more nutritious foods and avoid overeating, encouraging weight loss. Besides initial weight loss, semaglutide can help you maintain weight loss in the long run.<\/p>\n
How often do you take oral vs. injectable semaglutide?<\/p>\n
You take oral semaglutide once a day and injectable semaglutide once a week.<\/p>\n
What are the disadvantages of oral semaglutide?<\/p>\n
Some disadvantages of oral semaglutide:<\/p>\n
You might not lose as much weight compared to injectable semaglutide.<\/p>\n
You might experience more side effects compared to injectable semaglutide.<\/p>\n
You have it take a tablet every day, rather than an injection once a week.<\/p>\n
You have to take it on an empty stomach, 30 minutes before food and drinks.<\/p>\n
Can you switch from injectable semaglutide to oral semaglutide?<\/p>\n
You can switch from injectable semaglutide to oral semaglutide. Start by letting your healthcare provider know you\u2019d like to change to a different form of your GLP-1 receptor agonist medication. They can recommend the best way to come off injectable semaglutide, which may include slowly tapering down your dose.<\/p>\n
Related:<\/p>\n
Weight Loss Treatment Medication Kits<\/p>\n
Weight Loss Tips for Men: 12 Steps for Fitness Success<\/p>\n
Like MediaFeed\u2019s content? <\/p>\n
Be sure to follow us<\/p>\n
.\u00a0<\/p>\n
This article originally appeared on <\/p>\n
Hims.com<\/p>\n
\u00a0and was syndicated by\u00a0<\/p>\n
MediaFeed.org<\/p>\n","protected":false},"excerpt":{"rendered":"This article was reviewed by Darragh O\u2019Carroll, MD. Oral vs. Injectable Semaglutide: Effectiveness & Side Effects Key takeaways:…\n","protected":false},"author":2,"featured_media":360343,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[42],"tags":[102,6591,56,54,55],"class_list":["post-681882","post","type-post","status-publish","format-standard","has-post-thumbnail","category-medication","tag-health","tag-medication","tag-uk","tag-united-kingdom","tag-unitedkingdom"],"_links":{"self":[{"href":"https:\/\/www.newsbeep.com\/uk\/wp-json\/wp\/v2\/posts\/681882","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.newsbeep.com\/uk\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.newsbeep.com\/uk\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/uk\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/uk\/wp-json\/wp\/v2\/comments?post=681882"}],"version-history":[{"count":0,"href":"https:\/\/www.newsbeep.com\/uk\/wp-json\/wp\/v2\/posts\/681882\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/uk\/wp-json\/wp\/v2\/media\/360343"}],"wp:attachment":[{"href":"https:\/\/www.newsbeep.com\/uk\/wp-json\/wp\/v2\/media?parent=681882"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.newsbeep.com\/uk\/wp-json\/wp\/v2\/categories?post=681882"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.newsbeep.com\/uk\/wp-json\/wp\/v2\/tags?post=681882"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}