{"id":702463,"date":"2026-07-21T00:14:15","date_gmt":"2026-07-21T00:14:15","guid":{"rendered":"https:\/\/www.newsbeep.com\/uk\/702463\/"},"modified":"2026-07-21T00:14:15","modified_gmt":"2026-07-21T00:14:15","slug":"genome-wide-association-analyses-of-borderline-personality-disorder-identify-11-loci-and-highlight-shared-risk-with-mental-and-somatic-disorders","status":"publish","type":"post","link":"https:\/\/www.newsbeep.com\/uk\/702463\/","title":{"rendered":"Genome-wide association analyses of borderline personality disorder identify 11 loci and highlight shared risk with mental and somatic disorders"},"content":{"rendered":"<p class=\"c-article-author-affiliation__address\">Hector Institute for Artificial Intelligence in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Fabian Streit,\u00a0Joonas Naamanka\u00a0&amp;\u00a0Emanuel Schwarz<\/p>\n<p class=\"c-article-author-affiliation__address\">Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Fabian Streit,\u00a0Joonas Naamanka,\u00a0Maria Gilles,\u00a0Andreas Meyer-Lindenberg,\u00a0Emanuel Schwarz,\u00a0Tabea Sarah Send\u00a0&amp;\u00a0Michael Deuschle<\/p>\n<p class=\"c-article-author-affiliation__address\">Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Fabian Streit,\u00a0Josef Frank,\u00a0Lea Zillich,\u00a0Carolin M. Callies,\u00a0Diana Avetyan,\u00a0Eric Zillich,\u00a0Helene Dukal,\u00a0Mariana K. Espinola,\u00a0Jerome C. Foo,\u00a0Katja Simon-Keller,\u00a0Maja P. V\u00f6lker,\u00a0Marcella Rietschel\u00a0&amp;\u00a0Stephanie H. Witt<\/p>\n<p class=\"c-article-author-affiliation__address\">German Center for Mental Health (DZPG), Partner Site Mannheim-Heidelberg-Ulm, Mannheim-Heidelberg-Ulm, Germany<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Fabian Streit,\u00a0Lea Zillich,\u00a0Emanuel Schwarz,\u00a0Michael Deuschle,\u00a0Sabine C. Herpertz,\u00a0Christian Schmahl\u00a0&amp;\u00a0Stephanie H. Witt<\/p>\n<p class=\"c-article-author-affiliation__address\">Department of Psychiatry and Psychotherapy, Charit\u00e9 Universit\u00e4tsmedizin Berlin, Berlin, Germany<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Swapnil Awasthi,\u00a0Alice Braun,\u00a0Julia Kraft\u00a0&amp;\u00a0Stephan Ripke<\/p>\n<p class=\"c-article-author-affiliation__address\">Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Swapnil Awasthi,\u00a0Alice Braun\u00a0&amp;\u00a0Stephan Ripke<\/p>\n<p class=\"c-article-author-affiliation__address\">Department of Clinical Medicine, Aarhus University, Aarhus, Denmark<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Alisha S. M. Hall\u00a0&amp;\u00a0Christian Erikstrup<\/p>\n<p class=\"c-article-author-affiliation__address\">Department of Affective Disorders, Aarhus University Hospital-Psychiatry, Aarhus, Denmark<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Alisha S. M. Hall<\/p>\n<p class=\"c-article-author-affiliation__address\">Department of Medicine, Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, TN, USA<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Maria Niarchou,\u00a0Annika Faucon,\u00a0Peter Straub,\u00a0Lea K. Davis\u00a0&amp;\u00a0Sandra Sanchez-Roige<\/p>\n<p class=\"c-article-author-affiliation__address\">William Harvey Research Institute, Faculty of Medicine and Dentistry, Queen Mary University London, London, UK<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Eirini Marouli\u00a0&amp;\u00a0Oladapo Babajide<\/p>\n<p class=\"c-article-author-affiliation__address\">Hector Institute for Translational Brain Research, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Lea Zillich<\/p>\n<p class=\"c-article-author-affiliation__address\">Department of Psychiatry and Psychotherapy, Medical Center &#8211; University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Lea Zillich<\/p>\n<p class=\"c-article-author-affiliation__address\">Health Psychology, School of Social Sciences, University of Mannheim, Mannheim, Germany<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Carolin M. Callies<\/p>\n<p class=\"c-article-author-affiliation__address\">SleepWell Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Joonas Naamanka<\/p>\n<p class=\"c-article-author-affiliation__address\">Department of Psychiatry, University of California San Diego, La Jolla, CA, USA<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Jean Gonzalez\u00a0&amp;\u00a0Sandra Sanchez-Roige<\/p>\n<p class=\"c-article-author-affiliation__address\">Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Arvid Harder\u00a0&amp;\u00a0Yi Lu<\/p>\n<p class=\"c-article-author-affiliation__address\">Institute for Cardiogenetics, University of L\u00fcbeck, L\u00fcbeck, Germany<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Zouhair Aherrahrou<\/p>\n<p class=\"c-article-author-affiliation__address\">DZHK (German Research Centre for Cardiovascular Research), partner site Hamburg\/L\u00fcbeck\/Kiel, L\u00fcbeck, Germany<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Zouhair Aherrahrou<\/p>\n<p class=\"c-article-author-affiliation__address\">University Heart Center L\u00fcbeck, L\u00fcbeck, Germany<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Zouhair Aherrahrou<\/p>\n<p class=\"c-article-author-affiliation__address\">Social, Genetic and Developmental Psychiatry Centre, Institute of Psychology, Psychiatry and Neuroscience, King\u2019s College London, London, UK<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Zain-Ul-Abideen Ahmad,\u00a0Christopher H\u00fcbel,\u00a0Yuhao Lin,\u00a0Rujia Wang\u00a0&amp;\u00a0Gerome Breen<\/p>\n<p class=\"c-article-author-affiliation__address\">PsychGen Centre for Genetic Epidemiology and Mental Health, Norwegian Institute of Public Health, Oslo, Norway<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Helga Ask,\u00a0Elizabeth C. Corfield,\u00a0Alexandra Havdahl\u00a0&amp;\u00a0Ted Reichborn-Kjennerud<\/p>\n<p class=\"c-article-author-affiliation__address\">Department of Child Health and Development, Norwegian Institute of Public Health, Oslo, Norway<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Helga Ask<\/p>\n<p class=\"c-article-author-affiliation__address\">PROMENTA Research Center, Department of Psychology, University of Oslo, Oslo, Norway<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Helga Ask\u00a0&amp;\u00a0Alexandra Havdahl<\/p>\n<p class=\"c-article-author-affiliation__address\">Department of Quantitative Health Sciences, Division of Computational Biology, Mayo Clinic, Rochester, MN, USA<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Anthony Batzler,\u00a0Brandon J. Coombes\u00a0&amp;\u00a0Joanna M. Biernacka<\/p>\n<p class=\"c-article-author-affiliation__address\">Copenhagen Research Centre for Biological and Precision Psychiatry, Mental Health Centre Copenhagen, Copenhagen University Hospital, Copenhagen, Denmark<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Michael E. Benros<\/p>\n<p class=\"c-article-author-affiliation__address\">Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Michael E. Benros,\u00a0Henrik Hjalgrim,\u00a0Anders Jorgensen,\u00a0Sisse R. Ostrowski,\u00a0Ole B. V. Pedersen\u00a0&amp;\u00a0Thomas Werge<\/p>\n<p class=\"c-article-author-affiliation__address\">Netherlands Institute for Personality Disorders, Halsteren, Netherlands<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Odette M. Brand-de Wilde<\/p>\n<p class=\"c-article-author-affiliation__address\">Department of Public Health &amp; Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">S\u00f8ren Brunak<\/p>\n<p class=\"c-article-author-affiliation__address\">Clinical Immunology Research Unit, Department of Clinical Immunology, Odense University Hospital, Odense, Denmark<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Mie T. Bruun<\/p>\n<p class=\"c-article-author-affiliation__address\">Department of Clinical Immunology, Zealand University Hospital, K\u00f8ge, Denmark<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Lea A. N. Christoffersen,\u00a0Ole B. V. Pedersen\u00a0&amp;\u00a0Liam Quinn<\/p>\n<p class=\"c-article-author-affiliation__address\">Institute of Biological Psychiatry, Mental Health Services, University of Copenhagen, Copenhagen, Denmark<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Lea A. N. Christoffersen\u00a0&amp;\u00a0Thomas Werge<\/p>\n<p class=\"c-article-author-affiliation__address\">Brain and Mental Health Research Program, QIMR Berghofer, Brisbane, Queensland, Australia<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Luc\u00eda Colodro-Conde<\/p>\n<p class=\"c-article-author-affiliation__address\">School of Psychology, The University of Queensland, Brisbane, Queensland, Australia<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Luc\u00eda Colodro-Conde<\/p>\n<p class=\"c-article-author-affiliation__address\">Psychiatric Genetic Epidemiology Group, Research Department &amp; Nic Waals Institute, Lovisenberg Diaconal Hospital, Oslo, Norway<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Elizabeth C. Corfield\u00a0&amp;\u00a0Alexandra Havdahl<\/p>\n<p class=\"c-article-author-affiliation__address\">MRC Integrative Epidemiology Unit, Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Elizabeth C. Corfield<\/p>\n<p class=\"c-article-author-affiliation__address\">Department of Psychiatry and Psychotherapy, University Medical Center, University of Mainz, Mainz, Germany<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Norbert Dahmen,\u00a0Arian Mobascher\u00a0&amp;\u00a0Klaus Lieb<\/p>\n<p class=\"c-article-author-affiliation__address\">Department of Neuroscience, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Maria Didriksen<\/p>\n<p class=\"c-article-author-affiliation__address\">Department of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Maria Didriksen,\u00a0Khoa M. Dinh,\u00a0Joseph Dowsett,\u00a0Christina Mikkelsen,\u00a0Sisse R. Ostrowski,\u00a0Michael Schwinn,\u00a0Erik S\u00f8rensen\u00a0&amp;\u00a0Jacob Tr\u00e6holt<\/p>\n<p class=\"c-article-author-affiliation__address\">Department of Clinical Immunology, Aarhus University Hospital, Aarhus, Denmark<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Khoa M. Dinh,\u00a0Christian Erikstrup\u00a0&amp;\u00a0Susan Mikkelsen<\/p>\n<p class=\"c-article-author-affiliation__address\">Department of Medical Genetics, Oslo University Hospital, Oslo, Norway<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Srdjan Djurovic<\/p>\n<p class=\"c-article-author-affiliation__address\">Centre for Precision Psychiatry, Division of Mental Health and Addiction, Oslo University Hospital and Institute of Clinical Medicine, University of Oslo, Oslo, Norway<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Srdjan Djurovic,\u00a0Ole Kristian Drange\u00a0&amp;\u00a0Ole A. Andreassen<\/p>\n<p class=\"c-article-author-affiliation__address\">Department of Psychiatry, S\u00f8rlandet Hospital, Kristiansand, Agder, Norway<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Ole Kristian Drange<\/p>\n<p class=\"c-article-author-affiliation__address\">Department of Psychiatry and Psychotherapy, University Hospital T\u00fcbingen, T\u00fcbingen, Germany<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Susanne Edelmann,\u00a0Nora Knoblich\u00a0&amp;\u00a0Vanessa Nieratschker<\/p>\n<p class=\"c-article-author-affiliation__address\">German Center for Mental Health (DZPG), partner site T\u00fcbingen, T\u00fcbingen, Germany<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Susanne Edelmann\u00a0&amp;\u00a0Vanessa Nieratschker<\/p>\n<p class=\"c-article-author-affiliation__address\">Department of Psychiatry and Psychotherapy, Christian-Albrechts-Universit\u00e4t zu Kiel, Kiel, Germany<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Eva Fassbinder<\/p>\n<p class=\"c-article-author-affiliation__address\">Department of Psychology, Division of Clinical Psychology and Psychotherapy, Saarland University, Saarbr\u00fccken, Germany<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Diana S. Ferreira de S\u00e1<\/p>\n<p class=\"c-article-author-affiliation__address\">Institute for Psychopharmacology, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Jerome C. Foo<\/p>\n<p class=\"c-article-author-affiliation__address\">Department of Psychiatry, College of Health Sciences, University of Alberta, Edmonton, Alberta, Canada<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Jerome C. Foo<\/p>\n<p class=\"c-article-author-affiliation__address\">Neuroscience and Mental Health Institute, University of Alberta, Edmonton, Alberta, Canada<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Jerome C. Foo<\/p>\n<p class=\"c-article-author-affiliation__address\">Hospital Universitari Institut Pere Mata (HUIPM), Institute de Recerca Biom\u00e9dica Catalunya Sud (IRB-CatSud) previously IISPV-CERCA, Universitat Rovira i Virgili (URV), Reus, Spain<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Alfonso Guti\u00e9rrez-Zotes,\u00a0Gerard Muntan\u00e9,\u00a0Lourdes Martorell\u00a0&amp;\u00a0Elisabet Vilella<\/p>\n<p class=\"c-article-author-affiliation__address\">Biomedical Network Research Centre on Mental Health (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Alfonso Guti\u00e9rrez-Zotes,\u00a0Gerard Muntan\u00e9,\u00a0Lourdes Martorell,\u00a0Josep A. Ramos-Quiroga,\u00a0Marta Ribases\u00a0&amp;\u00a0Elisabet Vilella<\/p>\n<p class=\"c-article-author-affiliation__address\">Neurogenomic, Translational Research Centre, Copenhagen University Hospital, Glostrup, Denmark<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Thomas F. Hansen<\/p>\n<p class=\"c-article-author-affiliation__address\">Danish Headache Center, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Thomas F. Hansen<\/p>\n<p class=\"c-article-author-affiliation__address\">Landspitali University Hospital, Reykjavik, Iceland<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Magnus Haraldsson\u00a0&amp;\u00a0Engilbert Sigurdsson<\/p>\n<p class=\"c-article-author-affiliation__address\">Faculty of Medicine, Department of Psychiatry, School of Health Sciences, University of Iceland, Reykjavik, Iceland<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Magnus Haraldsson\u00a0&amp;\u00a0Engilbert Sigurdsson<\/p>\n<p class=\"c-article-author-affiliation__address\">Bradford District Care NHS Foundation Trust, Bradford, UK<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">R. Patrick Harper<\/p>\n<p class=\"c-article-author-affiliation__address\">Institute of Psychiatric Phenomics and Genomics (IPPG), LMU University Hospital, LMU Munich, Munich, Germany<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Urs Heilbronner<\/p>\n<p class=\"c-article-author-affiliation__address\">Human Genomics Research Group, Department of Biomedicine, University of Basel, Basel, Switzerland<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Stefan Herms<\/p>\n<p class=\"c-article-author-affiliation__address\">Institute of Human Genetics, University Hospital Bonn &amp; University of Bonn, Bonn, Germany<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Stefan Herms<\/p>\n<p class=\"c-article-author-affiliation__address\">Danish Cancer Institute, Copenhagen, Denmark<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Henrik Hjalgrim<\/p>\n<p class=\"c-article-author-affiliation__address\">Department of Haematology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Henrik Hjalgrim<\/p>\n<p class=\"c-article-author-affiliation__address\">UK National Institute for Health Research (NIHR) Biomedical Research Centre, South London and Maudsley Hospital and King\u2019s College London, London, UK<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Christopher H\u00fcbel,\u00a0Yuhao Lin,\u00a0Rujia Wang\u00a0&amp;\u00a0Gerome Breen<\/p>\n<p class=\"c-article-author-affiliation__address\">National Centre for Register-based Research, Aarhus University, Aarhus, Denmark<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Christopher H\u00fcbel<\/p>\n<p class=\"c-article-author-affiliation__address\">Clinic for Child and Adolescent Psychiatry, German Red Cross Hospitals Westend, Berlin, Germany<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Christopher H\u00fcbel<\/p>\n<p class=\"c-article-author-affiliation__address\">Institute for Psychology, Department of Clinical Psychology and Psychotherapy, University of Freiburg, Freiburg, Germany<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Gitta A. Jacob<\/p>\n<p class=\"c-article-author-affiliation__address\">Department of Clinical Immunology, Aalborg University Hospital, Aalborg, Denmark<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Bitten Aagaard<\/p>\n<p class=\"c-article-author-affiliation__address\">Psychiatric Center Copenhagen, Copenhagen, Denmark<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Anders Jorgensen<\/p>\n<p class=\"c-article-author-affiliation__address\">Institute for Medical and Data Ethics, Heidelberg University, Faculty of Medicine, Heidelberg, Germany<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Martin Jungkunz<\/p>\n<p class=\"c-article-author-affiliation__address\">German Cancer Research Center (DKFZ), Heidelberg, Germany<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Martin Jungkunz<\/p>\n<p class=\"c-article-author-affiliation__address\">Department of Psychosomatic Medicine and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Nikolaus Kleindienst,\u00a0Stefanie Lis,\u00a0Martin Bohus\u00a0&amp;\u00a0Christian Schmahl<\/p>\n<p class=\"c-article-author-affiliation__address\">Department of Psychiatry and Neurosciences, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt- Universit\u00e4t zu Berlin, Campus Benjamin Franklin, Berlin, Germany<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Stefanie Koglin,\u00a0Tolou Maslahati\u00a0&amp;\u00a0Stefan Roepke<\/p>\n<p class=\"c-article-author-affiliation__address\">Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Kristi Krebs\u00a0&amp;\u00a0Kelli Lehto<\/p>\n<p class=\"c-article-author-affiliation__address\">Faculty of Health and Medical Sciences, University of Western Australia, Perth, Western Australia, Australia<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Christopher W. Lee<\/p>\n<p class=\"c-article-author-affiliation__address\">Department of Clinical Psychology, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Stefanie Lis<\/p>\n<p class=\"c-article-author-affiliation__address\">Molecular Brain Science, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Amanda Lisoway\u00a0&amp;\u00a0James L. Kennedy<\/p>\n<p class=\"c-article-author-affiliation__address\">Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Amanda Lisoway\u00a0&amp;\u00a0James L. Kennedy<\/p>\n<p class=\"c-article-author-affiliation__address\">First Department of Psychiatry, Eginition Hospital Medical School, National and Kapodistrian University of Athens, Athens, Greece<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Ioannis A. Malogiannis<\/p>\n<p class=\"c-article-author-affiliation__address\">Department of Research and Innovation, Division of Clinical Neuroscience, Oslo University Hospital, Oslo, Norway<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Amy Martinsen,\u00a0John-Anker Zwart\u00a0&amp;\u00a0Bendik S. Winsvold<\/p>\n<p class=\"c-article-author-affiliation__address\">Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Amy Martinsen\u00a0&amp;\u00a0John-Anker Zwart<\/p>\n<p class=\"c-article-author-affiliation__address\">HUNT Center for Molecular and Clinical Epidemiology, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Amy Martinsen,\u00a0John-Anker Zwart\u00a0&amp;\u00a0Bendik S. Winsvold<\/p>\n<p class=\"c-article-author-affiliation__address\">Department of Psychiatry and Psychotherapy, LMU University Hospital Munich, Ludwig Maximilian University Munich, Munich, Germany<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Katharina Merz,\u00a0Matthias A. Reinhard,\u00a0Peter Zill,\u00a0Andrea Jobst,\u00a0Richard Musil\u00a0&amp;\u00a0Frank Padberg<\/p>\n<p class=\"c-article-author-affiliation__address\">Institut de Biologia Evolutiva (UPF-CSIC), Department of Medicine and Life Sciences, Universitat Pompeu Fabra, Parc de Recerca Biom\u00e8dica de Barcelona, Barcelona, Spain<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Gerard Muntan\u00e9<\/p>\n<p class=\"c-article-author-affiliation__address\">deCODE genetics \/ AMGEN, Reykjavik, Iceland<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Asmundur Oddsson,\u00a0Astros T. Skuladottir,\u00a0Hreinn Stefansson,\u00a0G. Bragi Walters,\u00a0Kari Stefansson\u00a0&amp;\u00a0Thorgeir E. Thorgeirsson<\/p>\n<p class=\"c-article-author-affiliation__address\">Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Teemu Palviainen,\u00a0Jaakko Kaprio\u00a0&amp;\u00a0Aarno Palotie<\/p>\n<p class=\"c-article-author-affiliation__address\">Department of Research and Innovation, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Geir Pedersen\u00a0&amp;\u00a0Benjamin Hummelen<\/p>\n<p class=\"c-article-author-affiliation__address\">Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, Oslo, Norway<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Geir Pedersen<\/p>\n<p class=\"c-article-author-affiliation__address\">German Center for Mental Health (DZPG), Partner Site Munich-Augsburg, Munich-Augsburg, Germany<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Matthias A. Reinhard\u00a0&amp;\u00a0Frank Padberg<\/p>\n<p class=\"c-article-author-affiliation__address\">South London and Maudsley NHS Foundation Trust, London, UK<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Florian A. Ruths<\/p>\n<p class=\"c-article-author-affiliation__address\">Department of Psychiatry and Psychotherapy, University Medical Center G\u00f6ttingen, G\u00f6ttingen, Germany<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Bj\u00f6rn H. Schott<\/p>\n<p class=\"c-article-author-affiliation__address\">German Center for Neurodegenerative Diseases (DZNE), G\u00f6ttingen, Germany<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Bj\u00f6rn H. Schott<\/p>\n<p class=\"c-article-author-affiliation__address\">Leibniz Institute for Neurobiology, Magdeburg, Germany<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Bj\u00f6rn H. Schott<\/p>\n<p class=\"c-article-author-affiliation__address\">Department of Psychiatry and Psychotherapy, Otto von Guericke University, Magdeburg, Germany<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Bj\u00f6rn H. Schott<\/p>\n<p class=\"c-article-author-affiliation__address\">Department of Psychiatry and Psychotherapy, Sleep Laboratory, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Michael Schredl\u00a0&amp;\u00a0Claudia Schilling<\/p>\n<p class=\"c-article-author-affiliation__address\">Department of Clinical Psychology and Psychotherapy, Charlotte Fresenius University, Wiesbaden, Germany<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Cornelia E. Schwarze<\/p>\n<p class=\"c-article-author-affiliation__address\">Faculty of Medicine, University of Iceland, Reykjavik, Iceland<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Astros T. Skuladottir\u00a0&amp;\u00a0Kari Stefansson<\/p>\n<p class=\"c-article-author-affiliation__address\">Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Salud Mental (CIBERSAM), Institut de Recerca Biom\u00e8dica Sant Pau (IIB-Sant Pau), Barcelona, Spain<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Joaquim Soler\u00a0&amp;\u00a0Juan C. Pascual<\/p>\n<p class=\"c-article-author-affiliation__address\">Department of Psychiatry, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Joaquim Soler\u00a0&amp;\u00a0Juan C. Pascual<\/p>\n<p class=\"c-article-author-affiliation__address\">Department of Psychiatry and Forensic Medicine &amp; Institute of Neurosciences, Universitat Aut\u00f2noma de Barcelona, Bellaterra, Spain<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Joaquim Soler<\/p>\n<p class=\"c-article-author-affiliation__address\">Borderline Personality Disorder Clinic, Centre for Addiction and Mental Health, Toronto, Ontario, Canada<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Anne Sonley<\/p>\n<p class=\"c-article-author-affiliation__address\">Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Anne Sonley,\u00a0James L. Kennedy\u00a0&amp;\u00a0Shelley McMain<\/p>\n<p class=\"c-article-author-affiliation__address\">Finnish Institute for Health and Welfare (THL), Helsinki, Finland<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Jaana Suvisaari<\/p>\n<p class=\"c-article-author-affiliation__address\">Mental health and suicide, Norwegian Institute of Public Health, Oslo, Norway<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Martin Tesli<\/p>\n<p class=\"c-article-author-affiliation__address\">Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Martin Tesli<\/p>\n<p class=\"c-article-author-affiliation__address\">Statens Serum Institut, Copenhagen, Denmark<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Henrik Ullum<\/p>\n<p class=\"c-article-author-affiliation__address\">Department of Anaesthesiology and Operative Intensive Care, University Hospital Mannheim, Medical Faculty Mannheim\/Heidelberg University, Mannheim, Germany<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Christian C. Witt<\/p>\n<p class=\"c-article-author-affiliation__address\">IVAH, Institut f\u00fcr Verhaltenstherapie-Ausbildung Hamburg, gemeinn\u00fctzige GmbH, Hamburg, Germany<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Gerhard Zarbock<\/p>\n<p class=\"c-article-author-affiliation__address\">KG Jebsen Centre for Neurodevelopmental Disorders, University of Oslo, Oslo, Norway<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Ole A. Andreassen<\/p>\n<p class=\"c-article-author-affiliation__address\">Department of Clinical Psychology, University of Amsterdam, Amsterdam, the Netherlands<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Arnoud Arntz<\/p>\n<p class=\"c-article-author-affiliation__address\">Department of Psychiatry &amp; Psychology, Division of Computational Biology, Mayo Clinic, Rochester, MN, USA<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Joanna M. Biernacka<\/p>\n<p class=\"c-article-author-affiliation__address\">Department of Psychology, Faculty of Arts and Social Sciences, Simon Fraser University, Vancouver, British Columbia, Canada<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Alexander L. Chapman<\/p>\n<p class=\"c-article-author-affiliation__address\">DBT Centre of Vancouver, Vancouver, British Columbia, Canada<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Alexander L. Chapman<\/p>\n<p class=\"c-article-author-affiliation__address\">Department of Biomedicine, University of Basel, Basel, Switzerland<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Sven Cichon<\/p>\n<p class=\"c-article-author-affiliation__address\">Medical Genetics, Institute of Medical Genetics and Pathology, University Hospital Basel, Basel, Switzerland<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Sven Cichon<\/p>\n<p class=\"c-article-author-affiliation__address\">Institute of Neuroscience and Medicine (INM-1), Research Center Juelich, Juelich, Germany<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Sven Cichon<\/p>\n<p class=\"c-article-author-affiliation__address\">Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, USA<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Lea K. Davis<\/p>\n<p class=\"c-article-author-affiliation__address\">Department of Consultation Psychiatry and Psychosomatics, University Hospital Zurich, Zurich, Switzerland<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Sebastian Euler<\/p>\n<p class=\"c-article-author-affiliation__address\">Department of General Psychiatry, University Hospital Heidelberg, Heidelberg University, Heidelberg, Germany<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Sabine C. Herpertz<\/p>\n<p class=\"c-article-author-affiliation__address\">Borderline Personality Disorder Clinic, General Adult Psychiatry and Health Systems Division, Centre for Addiction and Mental Health, Toronto, Ontario, Canada<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Shelley McMain<\/p>\n<p class=\"c-article-author-affiliation__address\">Oberberg Fachkliniken for Psychiatry, Psychosomatics and Psychotherapy, Bad T\u00f6lz, Germany<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Richard Musil<\/p>\n<p class=\"c-article-author-affiliation__address\">Insitute of Human Genetics, University Hospital Bonn &amp; University of Bonn, Bonn, Germany<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Markus M. N\u00f6then<\/p>\n<p class=\"c-article-author-affiliation__address\">Analytic and Translational Genetics Unit, Department of Medicine, Department of Neurology and Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Aarno Palotie<\/p>\n<p class=\"c-article-author-affiliation__address\">The Stanley Center for Psychiatric Research and Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Aarno Palotie<\/p>\n<p class=\"c-article-author-affiliation__address\">Mental Health and Psychiatry Department, Vic Hospital Consortium, Vic, Spain<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Juan C. Pascual<\/p>\n<p class=\"c-article-author-affiliation__address\">Department of Psychiatric, University Hospitals of Geneva, Geneva, Switzerland<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Nader Perroud<\/p>\n<p class=\"c-article-author-affiliation__address\">Psychiatric Genetics Unit, Group of Psychiatry, Mental Health and Addiction, Vall d\u2019Hebron Research Institute (VHIR), Universitat Aut\u00f2noma de Barcelona, Barcelona, Spain<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Josep A. Ramos-Quiroga\u00a0&amp;\u00a0Marta Ribases<\/p>\n<p class=\"c-article-author-affiliation__address\">Department of Psychiatry, Hospital Universitari Vall d\u2019Hebron, Barcelona, Spain<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Josep A. Ramos-Quiroga\u00a0&amp;\u00a0Marta Ribases<\/p>\n<p class=\"c-article-author-affiliation__address\">Department of Psychiatry and Forensic Medicine, Universitat Aut\u00f2noma de Barcelona (UAB), Barcelona, Spain<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Josep A. Ramos-Quiroga<\/p>\n<p class=\"c-article-author-affiliation__address\">Institute of Clinical Medicine, University of Oslo, Oslo, Norway<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Ted Reichborn-Kjennerud<\/p>\n<p class=\"c-article-author-affiliation__address\">Department of Genetics, Microbiology, and Statistics, Faculty of Biology, Universitat de Barcelona, Barcelona, Spain<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Marta Ribases<\/p>\n<p class=\"c-article-author-affiliation__address\">Department of Psychiatry, Oberberg Fachkliniken for Psychiatry, Psychosomatics and Psychotherapy, Wendisch Rietz, Germany<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Stefan Roepke<\/p>\n<p class=\"c-article-author-affiliation__address\">Department of Psychiatry, University of Halle, Halle, Germany<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Dan Rujescu<\/p>\n<p class=\"c-article-author-affiliation__address\">Institute for Genomic Medicine, University of California San Diego, La Jolla, CA, USA<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Sandra Sanchez-Roige<\/p>\n<p class=\"c-article-author-affiliation__address\">Douglas Institute, Department of Psychiatry, McGill University, Montreal, Quebec, Canada<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Gustavo Turecki<\/p>\n<p class=\"c-article-author-affiliation__address\">Department of Neurology, Oslo University Hospital, Oslo, Norway<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Bendik S. Winsvold<\/p>\n<p class=\"c-article-author-affiliation__address\">Medical Faculty, University of Basel, Basel, Switzerland<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Johannes Wrege<\/p>\n<p class=\"c-article-author-affiliation__address\">Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA<\/p>\n<p class=\"c-article-author-affiliation__authors-list\">Stephan Ripke<\/p>\n<p>F.S. and S.A. conceived of and designed the study, led the project and coordinated analyses. F.S., S.A., A.S.M.H., A. Braun, M.N., E.M., O.B., J.F., L.Z., C.M.C., D.A., E.Z., J.N., J.G., A. Harder and Y. Lu performed central analyses and contributed to data interpretation. F.S., S.A., A.S.M.H., A. Braun, M.N., E.M., L.C.-C., M.K.E., D.S.F.d.S., J.C.F., S.L., B.H.S., M. Schredl, E. Schwarz, M.P.V., C.C.W., S.S.-R., S. Ripke and S.H.W. drafted and revised the paper. The following authors contributed to the individual cohorts included in the study: Z.A., Z.-U.-A.A., H.A., A. Batzler, M.E.B., O.M.B.-d.W., S.B., M.T.B., L.A.N.C., B.J.C., E.C.C., N.D., M. Didriksen, K.M.D., S.D., J.D., O.K.D., H.D., S. Edelmann, C.E., E.F., A.F., J.C.F., M.G., A.G.-Z., T.F.H., M.H., R.P.H., A. Havdahl, U.H., S.H., H.H., C.H., G.A.J., B.A., A. Jorgensen, M.J., N. Kleindienst, N. Knoblich, S.K., J. Kraft, K.K., C.W.L., Y. Lin, S.L., A.L., I.A.M., A. Martinsen, T.M., K.M., A.M.-L., S. Mikkelsen, C.M., A. Mobascher, G.M., A.O., S.R.O., T.P., O.B.V.P., G.P., L.Q., M.A.R., F.A.R., B.H.S., M. Schredl, C.E.S., M. Schwinn, T.S.S., E. Sigurdsson, K.S.-K., A.T.S., J. Soler, A.S., E. S\u00f8rensen, H.S., P.S., J. Suvisaari, M.T., J.T., H.U., G.B.W., R.W., C.C.W., G.Z., P.Z. and J.-A.Z. performed cohort collection, genotyping, data generation and cohort-level analyses. O.A.A., A.A., J.M.B., M.B., G.B., A.L.C., S.C., L.K.D., M. Deuschle, S. Euler, S.C.H., B.H., A. Jobst, J. Kaprio, J.L.K., K. Lehto, K. Lieb, L.M., S. McMain, R.M., V.N., M.M.N., F.P., A.P., J.C.P., N.P., J.A.R.-Q., T.R.-K., M. Ribases, S. Roepke, D.R., S.S.-R., C. Schilling, C. Schmahl, K. Stefansson, T.E.T., G.T., E.V., T.W., B.S.W. and J.W. were the principal investigators responsible for individual cohorts and resources. M. Rietschel, S. Ripke and S.H.W. jointly supervised the study. All authors reviewed and approved the final paper.<\/p>\n","protected":false},"excerpt":{"rendered":"Hector Institute for Artificial Intelligence in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim,&hellip;\n","protected":false},"author":2,"featured_media":702464,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[10],"tags":[5083,5085,98857,3251,5082,59,5084,3250,5429,18005,102,5081,7125,56,54,55],"class_list":["post-702463","post","type-post","status-publish","format-standard","has-post-thumbnail","category-health","tag-agriculture","tag-animal-genetics-and-genomics","tag-behavioural-genetics","tag-biomedicine","tag-cancer-research","tag-gb","tag-gene-function","tag-general","tag-genetics-research","tag-genome-wide-association-studies","tag-health","tag-human-genetics","tag-psychiatric-disorders","tag-uk","tag-united-kingdom","tag-unitedkingdom"],"_links":{"self":[{"href":"https:\/\/www.newsbeep.com\/uk\/wp-json\/wp\/v2\/posts\/702463","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.newsbeep.com\/uk\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.newsbeep.com\/uk\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/uk\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/uk\/wp-json\/wp\/v2\/comments?post=702463"}],"version-history":[{"count":0,"href":"https:\/\/www.newsbeep.com\/uk\/wp-json\/wp\/v2\/posts\/702463\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/uk\/wp-json\/wp\/v2\/media\/702464"}],"wp:attachment":[{"href":"https:\/\/www.newsbeep.com\/uk\/wp-json\/wp\/v2\/media?parent=702463"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.newsbeep.com\/uk\/wp-json\/wp\/v2\/categories?post=702463"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.newsbeep.com\/uk\/wp-json\/wp\/v2\/tags?post=702463"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}