{"id":795502,"date":"2026-10-08T03:26:17","date_gmt":"2026-10-08T03:26:17","guid":{"rendered":"https:\/\/www.newsbeep.com\/uk\/795502\/"},"modified":"2026-10-08T03:26:17","modified_gmt":"2026-10-08T03:26:17","slug":"revealed-how-this-common-gut-microbe-protects-against-heart-disease","status":"publish","type":"post","link":"https:\/\/www.newsbeep.com\/uk\/795502\/","title":{"rendered":"Revealed: how this common gut microbe protects against heart disease"},"content":{"rendered":"

\"Cross-section<\/p>\n

Atherosclerosis involves the build up of fatty plaque (yellow) in the walls of arteries, limiting the flow of blood (red blood cells shown).Credit: Kateryna Kon\/Science Photo Library<\/p>\n

A gut microbe<\/a> that\u2019s commonly found in humans manufactures a molecule that is capable of slashing cholesterol<\/a> levels and shrinking plaque in arteries, according to a study published today in Nature1<\/a>.<\/p>\n

\"\"<\/p>\n

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When given to mice, the compound, from the gut bacterium Bacteroides uniformis, reduced the animals\u2019 arterial plaque by about half. It achieved the feat, researchers found, using the same biological action as that of statins, drugs that are prescribed to hundreds of millions of people worldwide to ward off cardiovascular disease.<\/p>\n

The findings underline new ways in which people\u2019s collection of gut microorganisms, known as their microbiome<\/a>, might be harnessed to protect the heart, says study co-author Wenjing Zhao, a microbiologist at Sun Yat-sen University in Shenzhen, China.<\/p>\n

The study provides \u201cvaluable evidence that the gut microbiome can influence vascular health\u201d, moving beyond a simple link between heart disease and the microbiome, and towards \u201cevidence for a potentially causal biological mechanism\u201d, says Ben Chen, a cardiovascular specialist at Monash Victorian Heart Institute in Melbourne, Australia.<\/p>\n

Matters of the heart<\/p>\n

Diseases caused by atherosclerosis, the progressive build up of inflammatory plaques in the walls of arteries, remain the leading cause of death globally. Although daily doses of statins have reduced deaths, this alone fails to reduce cholesterol sufficiently in nearly half of people with advanced heart disease. And some people can\u2019t tolerate high doses of the drugs.<\/p>\n

\"\"<\/p>\n

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To find an alternative, Zhao and her colleagues analysed the gut flora present in stool samples from people with and without cardiovascular disease. One species stood out: B. uniformis. That\u2019s because levels of the bacterium were often depleted in those with heart disease compared with healthy individuals.<\/p>\n

Next, researchers genetically engineered mice so that they developed atherosclerosis and fed them a high-fat diet to simulate the conditions in some people with heart disease. When the scientists administered live B. uniformis to the animals, it shrunk the plaques in their main arteries by about one-third, compared with the untreated mice. The bacterial dose also led to a drop in the levels of fatty substances in the blood, including total cholesterol and low-density lipoprotein (LDL), sometimes called \u2018bad cholesterol\u2019. Moreover, it reduced the amount of inflammatory immune cells infiltrating the rodents\u2019 arterial walls.<\/p>\n

Zhao and her colleagues isolated the molecule driving this protection: pentadecanoic acid. Further analyses showed that the molecule inhibits a liver enzyme involved in cholesterol production that is also targeted by statin medications. Blocking the enzyme triggers the liver to generate more LDL receptors, which in turn yank excess cholesterol out of the bloodstream.<\/p>\n

\"The<\/p>\n

The 3D and line structures of pentadecanoic acid (carbon, grey; oxygen, red; and hydrogen, white).Credit: Chromatos\/Shutterstock<\/p>\n

To see whether the animal findings would translate to people, Zhao\u2019s team examined blood and stool samples from more than 200 human donors. People with abnormally high concentrations of fatty molecules such as cholesterol in their blood had lower levels of pentadecanoic acid than did healthy individuals. Stool analyses also showed that people with heart disease carried fewer bacterial genes dedicated to manufacturing the molecule than did people in the control group.<\/p>\n","protected":false},"excerpt":{"rendered":"Atherosclerosis involves the build up of fatty plaque (yellow) in the walls of arteries, limiting the flow of…\n","protected":false},"author":2,"featured_media":795503,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[5],"tags":[84,47204,21124,59,4230,5672,4231,90,7923,56,54,55],"class_list":["post-795502","post","type-post","status-publish","format-standard","has-post-thumbnail","category-business","tag-business","tag-cardiovascular-biology","tag-diseases","tag-gb","tag-humanities-and-social-sciences","tag-microbiome","tag-multidisciplinary","tag-science","tag-therapeutics","tag-uk","tag-united-kingdom","tag-unitedkingdom"],"_links":{"self":[{"href":"https:\/\/www.newsbeep.com\/uk\/wp-json\/wp\/v2\/posts\/795502","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.newsbeep.com\/uk\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.newsbeep.com\/uk\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/uk\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/uk\/wp-json\/wp\/v2\/comments?post=795502"}],"version-history":[{"count":0,"href":"https:\/\/www.newsbeep.com\/uk\/wp-json\/wp\/v2\/posts\/795502\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/uk\/wp-json\/wp\/v2\/media\/795503"}],"wp:attachment":[{"href":"https:\/\/www.newsbeep.com\/uk\/wp-json\/wp\/v2\/media?parent=795502"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.newsbeep.com\/uk\/wp-json\/wp\/v2\/categories?post=795502"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.newsbeep.com\/uk\/wp-json\/wp\/v2\/tags?post=795502"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}