{"id":795998,"date":"2026-10-08T14:10:25","date_gmt":"2026-10-08T14:10:25","guid":{"rendered":"https:\/\/www.newsbeep.com\/uk\/795998\/"},"modified":"2026-10-08T14:10:25","modified_gmt":"2026-10-08T14:10:25","slug":"exercise-therapy-in-cancer-prevention-and-treatment","status":"publish","type":"post","link":"https:\/\/www.newsbeep.com\/uk\/795998\/","title":{"rendered":"Exercise therapy in cancer prevention and treatment"},"content":{"rendered":"

Fink, H. et al. Global and regional cancer burden attributable to modifiable risk factors to inform prevention. Nat. Med. 32, 1306\u20131315 (2026).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Weeden, C. E., Hill, W., Lim, E. L., Gr\u00f6nroos, E. & Swanton, C. Impact of risk factors on early cancer evolution. Cell 186, 1541\u20131563 (2023).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Dai, X., Gakidou, E. & Lopez, A. D. Evolution of the global smoking epidemic over the past half century: strengthening the evidence base for policy action. Tob. Control. 31, 129\u2013137 (2022).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

World Health Organization. WHO Global Report on Trends in Prevalence of Tobacco Use 2000\u20132030. WHO https:\/\/www.who.int\/publications\/i\/item\/9789240088283<\/a> (2024).<\/p>\n

Phelps, N. H. et al. Worldwide trends in underweight and obesity from 1990 to 2022: a pooled analysis of 3663 population-representative studies with 222 million children, adolescents, and adults. Lancet 403, 1027\u20131050 (2024).<\/p>\n

Article<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Taylor, S. R., Falcone, J. N., Cantley, L. C. & Goncalves, M. D. Developing dietary interventions as therapy for cancer. Nat. Rev. Cancer 22, 452\u2013466 (2022).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Kanarek, N., Petrova, B. & Sabatini, D. M. Dietary modifications for enhanced cancer therapy. Nature 579, 507\u2013517 (2020).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Caspersen, C. J., Powell, K. E. & Christenson, G. M. Physical activity, exercise, and physical fitness: definitions and distinctions for health-related research. Public. Health Rep. 100, 126\u2013131 (1985).<\/p>\n

PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Ewing, J. Animal experimentation and cancer. JAMA LIV, 267\u2013269 (1910).<\/p>\n

Article<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Jones, L. W. & Alfano, C. M. Exercise-oncology research: past, present, and future. Acta Oncol. 52, 195\u2013215 (2013).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Cormie, P. et al. Clinical Oncology Society of Australia position statement on exercise in cancer care. Med. J. Aust. 209, 184\u2013187 (2018).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Campbell, K. L. et al. Exercise guidelines for cancer survivors: consensus statement from international multidisciplinary roundtable. Med. Sci. Sports Exerc. 51, 2375\u20132390 (2019).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Ligibel, J. A. et al. Exercise, diet, and weight management during cancer treatment: ASCO guideline. J. Clin. Oncol. 40, 2491\u20132507 (2022).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Rock, C. L. et al. American Cancer Society nutrition and physical activity guideline for cancer survivors. CA. Cancer J. Clin. 72, 230\u2013262 (2022).<\/p>\n

PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Koelwyn, G. J., Quail, D. F., Zhang, X., White, R. M. & Jones, L. W. Exercise-dependent regulation of the tumour microenvironment. Nat. Rev. Cancer 17, 620\u2013632 (2017).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Ashcraft, K. A., Peace, R. M., Betof, A. S., Dewhirst, M. W. & Jones, L. W. Efficacy and mechanisms of aerobic exercise on cancer initiation, progression, and metastasis: a critical systematic review of in vivo preclinical data. Cancer Res. 76, 4032\u20134050 (2016).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Zhuang, X., Wong, E. S., Tammela, T. & Jones, L. W. Stem cells as an essential mediator of the exercise-tumorigenesis link. Nat. Rev. Cancer https:\/\/doi.org\/10.1038\/s41568-026-00933-z<\/a> (2026).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Nash, D. M., Terry, L. V. & Febbraio, M. A. Exercising through cancer: physical activity as medicine for cancer care. Cancer Cell 43, 2175\u20132180 (2025).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Sivertsen, I. & Dahlstrom, A. W. The relation of muscular activity to carcinoma: a preliminary report. J. Cancer Res. 6, 365\u2013378 (1921).<\/p>\n


\n Google Scholar<\/a>\u00a0\n <\/p>\n

Rusch, H. P. & Kline, B. E. The effect of exercise on the growth of a mouse tumor. Cancer Res. 4, 116\u2013118 (1944).<\/p>\n


\n Google Scholar<\/a>\u00a0\n <\/p>\n

Frisch, R. E. et al. Lower prevalence of breast cancer and cancers of the reproductive system among former college athletes compared to non-athletes. Br. J. Cancer 52, 885\u2013891 (1985).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Bernstein, L. et al. The effects of moderate physical activity on menstrual cycle patterns in adolescence: implications for breast cancer prevention. Br. J. Cancer 55, 681\u2013685 (1987).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Albanes, D., Blair, A. & Taylor, P. R. Physical activity and risk of cancer in the NHANES I population. Am. J. Public. Health 79, 744\u2013750 (1989).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Thune, I., Brenn, T., Lund, E. & Gaard, M. Physical activity and the risk of breast cancer. N. Engl. J. Med. 336, 1269\u20131275 (1997).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Bernstein, L., Henderson, B. E., Hanisch, R., Sullivan-Halley, J. & Ross, R. K. Physical exercise and reduced risk of breast cancer in young women. J. Natl Cancer Inst. 86, 1403\u20131408 (1994).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Giovannucci, E. et al. Physical activity, obesity, and risk for colon cancer and adenoma in men. Ann. Intern. Med. 122, 327\u2013334 (1995).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Mart\u00ednez, M. E. et al. Leisure-time physical activity, body size, and colon cancer in women. Nurses\u2019 Health Study Research Group. J. Natl Cancer Inst. 89, 948\u2013955 (1997).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Physical Activity Guidelines Advisory Committee. Physical Activity Guidelines Advisory Committee Report, 2008. US Department of Health and Human Services https:\/\/odphp.health.gov\/sites\/default\/files\/2019-10\/CommitteeReport_7.pdf<\/a> (2008).<\/p>\n

Moore, S. C. et al. Association of leisure-time physical activity with risk of 26 types of cancer in 1.44 million adults. JAMA Intern. Med. 176, 816\u2013825 (2016).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Lavery, J. A. et al. Association of exercise with pan-cancer incidence and overall survival. Cancer Cell 42, 169\u2013171 (2024).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Matthews, C. E. et al. Amount and intensity of leisure-time physical activity and lower cancer risk. J. Clin. Oncol. 38, 686\u2013697 (2020).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Nascimento, W. et al. Muscle-strengthening activities and cancer incidence and mortality: a systematic review and meta-analysis of observational studies. Int. J. Behav. Nutr. Phys. Act. 18, 69 (2021).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

McTiernan, A. et al. Physical activity in cancer prevention and survival: a systematic review. Med. Sci. Sports Exerc. 51, 1252\u20131261 (2019).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Rey-L\u00f3pez, J. P., Lee, D. H., Ferrari, G., Giovannucci, E. & Rezende, L. F. M. Physical activity intensity measurement and health: state of the art and future directions for scientific research. Int. J. Environ. Res. Public. Health 20, 6027 (2023).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Shreves, A. H. et al. Amount and intensity of daily total physical activity, step count and risk of incident cancer in the UK Biobank. Br. J. Sports Med. 59, 839\u2013847 (2025).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Parada, H. et al. Associations of accelerometer-measured physical activity and physical activity-related cancer incidence in older women: results from the WHI OPACH study. Br. J. Cancer 122, 1409\u20131416 (2020).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Del Pozo Cruz, B., Ahmadi, M. N., Lee, I.-M. & Stamatakis, E. Prospective associations of daily step counts and intensity with cancer and cardiovascular disease incidence and mortality and all-cause mortality. JAMA Intern. Med. 182, 1139\u20131148 (2022).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Prince, S. A. et al. A comparison of direct versus self-report measures for assessing physical activity in adults: a systematic review. Int. J. Behav. Nutr. Phys. Act. 5, 56 (2008).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Ding, D., Tarp, J., Giovannucci, E. & Clare, P. J. Causal inference in physical activity epidemiology research: an opportunity for better evidence. Br. J. Sports Med. 59, 963\u2013965 (2025).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Shrank, W. H., Patrick, A. R. & Brookhart, M. A. Healthy user and related biases in observational studies of preventive interventions: a primer for physicians. J. Gen. Intern. Med. 26, 546\u2013550 (2011).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Inayama, Y. et al. Changes in physical activity across cancer diagnosis and treatment based on smartphone step count data linked to a Japanese claims database: retrospective cohort study. JMIR Cancer 11, e58093 (2025).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Cook, N. R., Rosner, B. A., Hankinson, S. E. & Colditz, G. A. Mammographic screening and risk factors for breast cancer. Am. J. Epidemiol. 170, 1422\u20131432 (2009).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Pinsky, P. F. et al. Evidence of a healthy volunteer effect in the prostate, lung, colorectal, and ovarian cancer screening trial. Am. J. Epidemiol. 165, 874\u2013881 (2007).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Carethers, J. M. & Doubeni, C. A. Causes of socioeconomic disparities in colorectal cancer and intervention framework and strategies. Gastroenterology 158, 354\u2013367 (2020).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Neilson, H. K. et al. Moderate-vigorous recreational physical activity and breast cancer risk, stratified by menopause status: a systematic review and meta-analysis. Menopause 24, 322\u2013344 (2017).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Chalitsios, C. V. et al. Physical activity and molecular subtypes of colorectal cancer: a pooled observational analysis and Mendelian randomization study. JNCI Cancer Spectr. 9, pkaf095 (2025).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Papadimitriou, N. et al. Physical activity and risks of breast and colorectal cancer: a Mendelian randomisation analysis. Nat. Commun. 11, 597 (2020).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Hern\u00e1n, M. A., Wang, W. & Leaf, D. E. Target trial emulation: a framework for causal inference from observational data. JAMA 328, 2446\u20132447 (2022).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Schatzkin, A. & Gail, M. The promise and peril of surrogate end points in cancer research. Nat. Rev. Cancer 2, 19\u201327 (2002).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Key, T. J. et al. Circulating sex hormones and breast cancer risk factors in postmenopausal women: reanalysis of 13 studies. Br. J. Cancer 105, 709\u2013722 (2011).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Gunter, M. J. et al. Insulin, insulin-like growth factor-I, and risk of breast cancer in postmenopausal women. J. Natl Cancer Inst. 101, 48\u201360 (2009).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Chan, D. S. M., Bandera, E. V., Greenwood, D. C. & Norat, T. Circulating C-reactive protein and breast cancer risk-systematic literature review and meta-analysis of prospective cohort studies. Cancer Epidemiol. Biomarkers Prev. 24, 1439\u20131449 (2015).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

McTiernan, A. et al. Effect of exercise on serum estrogens in postmenopausal women: a 12-month randomized clinical trial. Cancer Res. 64, 2923\u20132928 (2004).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Friedenreich, C. M. et al. Alberta physical activity and breast cancer prevention trial: sex hormone changes in a year-long exercise intervention among postmenopausal women. J. Clin. Oncol. 28, 1458\u20131466 (2010).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Friedenreich, C. M. et al. Changes in insulin resistance indicators, IGFs, and adipokines in a year-long trial of aerobic exercise in postmenopausal women. Endocr. Relat. Cancer 18, 357\u2013369 (2011).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Friedenreich, C. M. et al. Inflammatory marker changes in a yearlong randomized exercise intervention trial among postmenopausal women. Cancer Prev. Res. 5, 98\u2013108 (2012).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Friedenreich, C. M. et al. Study design and methods for the Breast Cancer and Exercise Trial in Alberta (BETA). BMC Cancer 14, 919 (2014).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Friedenreich, C. M. et al. Long-term effects of moderate versus high durations of aerobic exercise on biomarkers of breast cancer risk: follow-up to a randomized controlled trial. Cancer Epidemiol. Biomarkers Prev. 28, 1725\u20131734 (2019).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Chlebowski, R. T. Lifestyle and breast cancer risk: the way forward? J. Clin. Oncol. 28, 1445\u20131447 (2010).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

McTiernan, A. et al. Effect of exercise on serum androgens in postmenopausal women: a 12-month randomized clinical trial. Cancer Epidemiol. Biomarkers Prev. 13, 1099\u20131105 (2004).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Ballard-Barbash, R. et al. Physical activity, biomarkers, and disease outcomes in cancer survivors: a systematic review. J. Natl Cancer Inst. 104, 815\u2013840 (2012).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Francis, E. R., Syed, F. Z., Rajan, A. & Szabo, E. Cancer prevention clinical trials: advances and challenges. Cancers 18, 390 (2026).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Gorski, D. H. Integrative oncology: really the best of both worlds? Nat. Rev. Cancer 14, 692\u2013700 https:\/\/doi.org\/10.1038\/nrc3822<\/a> (2014).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Jones, L. W. et al. A co-clinical trial of exercise therapy in breast cancer prevention. Clin. Cancer Res. 31, 3377\u20133387 (2025).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

McTiernan, A. et al. Effect of a 12-month exercise intervention on patterns of cellular proliferation in colonic crypts: a randomized controlled trial. Cancer Epidemiol. Biomarkers Prev. 15, 1588\u20131597 (2006).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Campbell, K. L. et al. Effect of a 12-month exercise intervention on the apoptotic regulating proteins Bax and Bcl-2 in colon crypts: a randomized controlled trial. Cancer Epidemiol. Biomarkers Prev. 16, 1767\u20131774 (2007).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Deng, N. et al. Exercise training reduces the inflammatory response and promotes intestinal mucosa-associated immunity in Lynch syndrome. Clin. Cancer Res. 29, 4361\u20134372 (2023).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Holmes, M. D., Chen, W. Y., Feskanich, D., Kroenke, C. H. & Colditz, G. A. Physical activity and survival after breast cancer diagnosis. JAMA 293, 2479\u20132486 (2005).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Friedenreich, C. M., Stone, C. R., Cheung, W. Y. & Hayes, S. C. Physical activity and mortality in cancer survivors: a systematic review and meta-analysis. JNCI Cancer Spectr. 4, pkz080 (2020).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Lavery, J. A. et al. Pan-cancer analysis of postdiagnosis exercise and mortality. J. Clin. Oncol. 41, 4982\u20134992 (2023).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Rees-Punia, E. et al. Leisure-time physical activity and cancer mortality among cancer survivors. JAMA Netw. Open 9, e2556971 (2026).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

German, R. R. et al. The accuracy of cancer mortality statistics based on death certificates in the United States. Cancer Epidemiol. 35, 126\u2013131 (2011).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Sternfeld, B. et al. Physical activity and risk of recurrence and mortality in breast cancer survivors: findings from the LACE study. Cancer Epidemiol. Biomarkers Prev. 18, 87\u201395 (2009).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Nechuta, S. J. et al. The After Breast Cancer Pooling Project: rationale, methodology, and breast cancer survivor characteristics. Cancer Causes Control. 22, 1319\u20131331 (2011).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Beasley, J. M. et al. Meeting the physical activity guidelines and survival after breast cancer: findings from the After Breast Cancer Pooling Project. Breast Cancer Res. Treat. 131, 637\u2013643 (2012).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Soldato, D. et al. Dose\/exposure relationship of exercise and distant recurrence in primary breast cancer. J. Clin. Oncol. 42, 3022\u20133032 (2024).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Jones, L. W. et al. Exercise and prognosis on the basis of clinicopathologic and molecular features in early-stage breast cancer: the LACE and Pathways studies. Cancer Res. 76, 5415\u20135422 (2016).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Cariolou, M. et al. Postdiagnosis recreational physical activity and breast cancer prognosis: Global Cancer Update Programme (CUP Global) systematic literature review and meta-analysis. Int. J. Cancer 152, 600\u2013615 (2023).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Meyerhardt, J. A. et al. Impact of physical activity on cancer recurrence and survival in patients with stage III colon cancer: findings from CALGB 89803. J. Clin. Oncol. 24, 3535\u20133541 (2006).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Brown, J. C. et al. Physical activity in stage III colon cancer: CALGB\/SWOG 80702 (Alliance). J. Clin. Oncol. 41, 243\u2013254 (2023).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

An, K.-Y. et al. Postdiagnosis physical activity is associated with improved survival in prostate cancer patients treated with surgery but not with radiation therapy. Br. J. Cancer 133, 1029\u20131037 (2025).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Guercio, B. J. et al. Associations of physical activity with survival and progression in metastatic colorectal cancer: results from Cancer and Leukemia Group B (Alliance)\/SWOG 80405. J. Clin. Oncol. 37, 2620\u20132631 (2019).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Zimmer, P. et al. Physical activity levels are positively related to progression-free survival and reduced adverse events in advanced ER+ breast cancer. BMC Med. 22, 442 (2024).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Ziegler, P. et al. The impact of physical activity on progression-free and overall survival in metastatic breast cancer based on molecular subtype. BMC Cancer 24, 1284 (2024).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Patel, A. V. et al. American College of Sports Medicine Roundtable Report on physical activity, sedentary behavior, and cancer prevention and control. Med. Sci. Sports Exerc. 51, 2391\u20132402 (2019).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Demark-Wahnefried, W., Wilson, O. W. A. & Courneya, K. S. Target trial emulation to estimate the effects of lifestyle interventions on mortality among cancer survivors: an editorial commentary. Ann. Cancer Epidemiol. 9, 4 https:\/\/doi.org\/10.21037\/ace-2025-12<\/a> (2025).<\/p>\n

Article<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Courneya, K. S. et al. Structured exercise after adjuvant chemotherapy for colon cancer. N. Engl. J. Med. 393, 13\u201325 (2025).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Bartoletti, M. et al. Number needed to treat in trials of targeted therapies for advanced ovarian cancer. JAMA Netw. Open 5, e2245077 (2022).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Sugarman, R., Nunna, S., Betts, K. A., Nie, X. & Nguyen, H. Number needed to treat (NNT) analysis of patients in CheckMate 649 (CM 649): nivolumab plus chemotherapy versus chemotherapy as first-line (1\u2009L) treatment for advanced gastric cancer, gastroesophageal junction cancer, and esophageal adenocarcinoma (GC\/GEJ\/EAC) [abstract]. J. Clin. Oncol. 40, 307 (2022).<\/p>\n

Article<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Dhillon, N., Kaura, S., Dranitsaris, G. & Rugo, H. Number needed to treat (NNT) to compare benefits of letrozole (LET) with adjuvant chemotherapy (CT) in patients (pts) with node-positive (N\u2009+\u2009) breast cancer (BC) [abstract]. J. Clin. Oncol. 27, 581 (2009).<\/p>\n

Article<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Kanani, A. et al. Neoadjuvant immunotherapy followed by surgery compared with upfront surgery alone in operable colon cancer with deficient mismatch repair: modeling oncological outcomes and numbers needed to treat. Ann. Surg. Oncol. 32, 3068\u20133077 (2025).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Hayes, S. et al. Exercise during Chemotherapy for Ovarian cancer (ECHO) trial: design and implementation of a randomised controlled trial. BMJ Open 13, e067925 (2023).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Hayes, S. et al. Exercise therapy added to first-line chemotherapy for ovarian cancer: effects on progression-free survival and physical wellbeing in the randomised, phase 3 ECHO trial (ANZGOG1304\/CTC121) [abstract]. Int. J. Gynecol. Cancer 35, 102735 (2025).<\/p>\n

Article<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Dubu, J. et al. Physical activity program for the survival of elderly patients with lymphoma: study protocol for randomized phase 3 trial. JMIR Res. Protoc. 11, e40969 (2022).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Betof, A. S., Dewhirst, M. W. & Jones, L. W. Effects and potential mechanisms of exercise training on cancer progression: a translational perspective. Brain. Behav. Immun. 30, S75\u2013S87 (2013).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Schmitz, K. H., Ahmed, R. L., Hannan, P. J. & Yee, D. Safety and efficacy of weight training in recent breast cancer survivors to alter body composition, insulin, and insulin-like growth factor axis proteins. Cancer Epidemiol. Biomarkers Prev. 14, 1672\u20131680 (2005).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Winters-Stone, K. M., Wood, L. J., Stoyles, S. & Dieckmann, N. F. The effects of resistance exercise on biomarkers of breast cancer prognosis: a pooled analysis of three randomized trials. Cancer Epidemiol. Biomarkers Prev. 27, 146\u2013153 (2018).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Meyerhardt, J. A. et al. Randomized phase II trial of exercise, metformin, or both on metabolic biomarkers in colorectal and breast cancer survivors. JNCI Cancer Spectr. 4, pkz096 (2020).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Kleckner, I. R. et al. Effects of exercise on inflammation in patients receiving chemotherapy: a nationwide NCORP randomized clinical trial. Support. Care Cancer 27, 4615\u20134625 (2019).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Schauer, T. et al. Exercise intensity and markers of inflammation during and after (neo-) adjuvant cancer treatment. Endocr. Relat. Cancer 28, 191\u2013201 (2021).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Toffoli, E. C. et al. Effects of physical exercise on natural killer cell activity during (neo)adjuvant chemotherapy: a randomized pilot study. Physiol. Rep. 9, e14919 (2021).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Parent-Roberge, H. et al. Acute natural killer cells response to a continuous moderate intensity and a work-matched high intensity interval exercise session in metastatic cancer patients treated with chemotherapy. Brain Behav. Immun. Health 40, 100825 (2024).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Koivula, T. et al. The effect of acute exercise on immune cell counts in newly diagnosed breast cancer patients [abstract 2835]. Med. Sci. Sports Exerc. 55, 967\u2013968 (2023).<\/p>\n

Article<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

MacDonald, G. et al. A pilot study of high-intensity interval training in older adults with treatment na\u00efve chronic lymphocytic leukemia. Sci. Rep. 11, 23137 (2021).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Joseph, J. M. et al. T cell exhaustion markers in multiple myeloma patients are lower after physical activity intervention. Clin. Lymphoma Myeloma Leuk. 24, 621\u2013628 (2024).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Marron, T. U. et al. Neoadjuvant clinical trials provide a window of opportunity for cancer drug discovery. Nat. Med. 28, 626\u2013629 (2022).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Glimelius, B. & Lahn, M. Window-of-opportunity trials to evaluate clinical activity of new molecular entities in oncology. Ann. Oncol 22, 1717\u20131725 (2011).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Ligibel, J. A. et al. Impact of a pre-operative exercise intervention on breast cancer proliferation and gene expression: results from the Pre-Operative Health and Body (PreHAB) Study. Clin. Cancer Res. 25, 5398\u20135406 (2019).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Jones, L. W. et al. Neoadjuvant exercise therapy in prostate cancer: a phase 1, decentralized nonrandomized controlled trial. JAMA Oncol. 10, 1187\u20131194 (2024).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Iyengar, N. M. & Jones, L. W. Development of exercise as interception therapy for cancer: a review. JAMA Oncol. 5, 1620\u20131627 (2019).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Burn, J. et al. Cancer prevention with aspirin in hereditary colorectal cancer (Lynch syndrome), 10-year follow-up and registry-based 20-year data in the CAPP2 study: a double-blind, randomised, placebo-controlled trial. Lancet 395, 1855\u20131863 (2020).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Reyes-Uribe, L. et al. Naproxen chemoprevention promotes immune activation in Lynch syndrome colorectal mucosa. Gut 70, 555\u2013566 (2021).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Blagden, S. P., Dodd, K. W., Brown, K. & Szabo, E. Precision prevention studies: a targeted approach to cancer prevention. Cancer Prev. Res. 18, 499\u2013507 (2025).<\/p>\n

Article<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Betof, A. S. et al. Modulation of murine breast tumor vascularity, hypoxia, and chemotherapeutic response by exercise. J. Natl Cancer Inst. 107, djv040 (2015).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Jones, L. W. et al. Exercise modulation of the host-tumor interaction in an orthotopic model of murine prostate cancer. J. Appl. Physiol. 113, 263\u2013272 (2012).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Schadler, K. L. et al. Tumor vessel normalization after aerobic exercise enhances chemotherapeutic efficacy. Oncotarget 7, 65429\u201365440 (2016).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Jones, L. W. et al. Effect of aerobic exercise on tumor physiology in an animal model of human breast cancer. J. Appl. Physiol. 108, 343\u2013348 (2010).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Chen, Z., Han, F., Du, Y., Shi, H. & Zhou, W. Hypoxic microenvironment in cancer: molecular mechanisms and therapeutic interventions. Signal. Transduct. Target. Ther. 8, 70 (2023).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Vaupel, P. & Mayer, A. Hypoxia in cancer: significance and impact on clinical outcome. Cancer Metastasis Rev. 26, 225\u2013239 (2007).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Wicks, E. E. & Semenza, G. L. Hypoxia-inducible factors: cancer progression and clinical translation. J. Clin. Invest. 132, e159839 (2022).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Ballar\u00f2, R. et al. Aerobic exercise activates S1PR1 signaling in tumor endothelial cells to promote vascular function in pancreatic cancer. Cancer Res. https:\/\/doi.org\/10.1158\/0008-5472.CAN-25-4733<\/a> (2026).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Sanft, T. et al. Randomized trial of exercise and nutrition on chemotherapy completion and pathologic complete response in women with breast cancer: the Lifestyle, Exercise, and Nutrition Early After Diagnosis Study. J. Clin. Oncol. 41, 5285\u20135295 (2023).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Iyengar, N. M. et al. Effects of exercise therapy on chemotherapy delivery and response in primary breast cancer: a secondary analysis of a randomized trial. Cancer 131, e35575 (2025).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Kjeldsted, E. et al. Effects of supervised exercise during neoadjuvant chemotherapy on tumor response in patients with breast cancer (Neo-train): a randomized controlled trial. Clin. Cancer Res. 31, 4265\u20134277 (2025).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Schmidt, M. E. et al. Effects of aerobic or resistance exercise during neoadjuvant chemotherapy on tumor response and therapy completion in women with breast cancer: the randomized controlled BENEFIT trial. J. Sport. Health Sci. 14, 101064 (2025).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

de Boniface, J., Altena, R., Ringborg, C. H., Bolam, K. A. & Wengstr\u00f6m, Y. Physical exercise during neoadjuvant chemotherapy for breast cancer as a mean to increase pathological complete response rates: trial protocol of the randomized Neo-ACT trial. PLoS ONE 17, e0274804 (2022).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Giraldo, N. A. et al. The clinical role of the TME in solid cancer. Br. J. Cancer 120, 45\u201353 (2019).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Phelps, C. M. et al. Exercise-induced microbiota metabolite enhances CD8 T cell antitumor immunity promoting immunotherapy efficacy. Cell 188, 5680\u20135700.e28 (2025).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Rundqvist, H. et al. Cytotoxic T-cells mediate exercise-induced reductions in tumor growth. eLife 9, e59996 (2020).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Gomes-Santos, I. L. et al. Exercise training improves tumor control by increasing CD8+ T-cell infiltration via CXCR3 signaling and sensitizes breast cancer to immune checkpoint blockade. Cancer Immunol. Res. 9, 765\u2013778 (2021).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Kurz, E. et al. Exercise-induced engagement of the IL-15\/IL-15R\u03b1 axis promotes anti-tumor immunity in pancreatic cancer. Cancer Cell 40, 720\u2013737.e5 (2022).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Verheijden, R. J. et al. Physical activity and checkpoint inhibition: association with toxicity and survival. J. Natl Cancer Inst. 116, 573\u2013579 (2024).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Loo, K. et al. Association between exercise and clinical outcomes in patients treated with immunotherapy for solid tumors. Front. Immunol. 16, 1694045 (2025).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Yamauchi, M. et al. Physical activity, tumor PTGS2 expression, and survival in patients with colorectal cancer. Cancer Epidemiol. Biomarkers Prev. 22, 1142\u20131152 (2013).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Morikawa, T. et al. Association of CTNNB1 (\u03b2-catenin) alterations, body mass index, and physical activity with survival in patients with colorectal cancer. JAMA 305, 1685\u20131694 (2011).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Meyerhardt, J. A. et al. Interaction of molecular markers and physical activity on mortality in patients with colon cancer. Clin. Cancer Res. 15, 5931\u20135936 (2009).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Fitzgerald, R. C., Antoniou, A. C., Fruk, L. & Rosenfeld, N. The future of early cancer detection. Nat. Med. 28, 666\u2013677 (2022).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Widman, A. J. et al. Ultrasensitive plasma-based monitoring of tumor burden using machine-learning-guided signal enrichment. Nat. Med. 30, 1655\u20131666 (2024).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Kotani, D. et al. Molecular residual disease and efficacy of adjuvant chemotherapy in patients with colorectal cancer. Nat. Med. 29, 127\u2013134 (2023).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Herrmann, S. D. et al. Adult compendium of physical activities: a third update of the energy costs of human activities. J. Sport. Health Sci. 13, 6\u201312 (2024).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Meyerhardt, J. A. et al. Physical activity and survival after colorectal cancer diagnosis. J. Clin. Oncol. 24, 3527\u20133534 (2006).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Contrepois, K. et al. Molecular choreography of acute exercise. Cell 181, 1112\u20131130.e16 (2020).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Pedersen, L. et al. Voluntary running suppresses tumor growth through epinephrine- and IL-6-dependent NK cell mobilization and redistribution. Cell Metab. 23, 554\u2013562 (2016).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Smith, K. A. et al. Exercise-induced \u03b22-adrenergic receptor activation enhances effector lymphocyte mobilization in humans and suppresses lymphoma growth in mice through NK-cells. Brain. Behav. Immun. 128, 751\u2013765 (2025).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Gomes-Santos, I. L. et al. Exercise intensity governs tumor control in mice with breast cancer. Front. Immunol. 15, 1339232 (2024).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Jones, L. W. Precision oncology framework for investigation of exercise as treatment for cancer. J. Clin. Oncol. 33, 4134\u20134137 (2015).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Monninkhof, E. M., Velthuis, M. J., Peeters, P. H. M., Twisk, J. W. R. & Schuit, A. J. Effect of exercise on postmenopausal sex hormone levels and role of body fat: a randomized controlled trial. J. Clin. Oncol. 27, 4492\u20134499 (2009).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Friedenreich, C. M. et al. Adiposity changes after a 1-year aerobic exercise intervention among postmenopausal women: a randomized controlled trial. Int. J. Obes. 35, 427\u2013435 (2011).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Woolcott, C. G. et al. Mammographic density change with 1 year of aerobic exercise among postmenopausal women: a randomized controlled trial. Cancer Epidemiol. Biomarkers Prev. 19, 1112\u20131121 (2010).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

van Gemert, W. A. et al. Effect of weight loss, with or without exercise, on body composition and sex hormones in postmenopausal women: the SHAPE-2 trial. Breast Cancer Res. 17, 120 (2015).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Schmitz, K. H. et al. Dose\u2013response effects of aerobic exercise on estrogen among women at high risk for breast cancer: a randomized controlled trial. Breast Cancer Res. Treat. 154, 309\u2013318 (2015).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Sturgeon, K. et al. Exercise-induced dose-response alterations in adiponectin and leptin levels are dependent on body fat changes in women at risk for breast cancer. Cancer Epidemiol. Biomarkers Prev. 25, 1195\u20131200 (2016).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Dash, C. et al. An exercise trial targeting African-American women with metabolic syndrome and at high risk for breast cancer: rationale, design, and methods. Contemp. Clin. Trials 43, 33\u201338 (2015).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Adams-Campbell, L. L., Taylor, T., Hicks, J., Lu, J. & Dash, C. The effect of a 6-month exercise intervention trial on allostatic load in black women at increased risk for breast cancer: the FIERCE study. J. Racial Ethn. Health Disparities 9, 2063\u20132069 (2022).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Rees-Punia, E. et al. Leisure-time physical activity after diagnosis and survival by cancer type: a pooled analysis. J. Natl Cancer Inst. 117, 1689\u20131698 (2025).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Holick, C. N. et al. Physical activity and survival after diagnosis of invasive breast cancer. Cancer Epidemiol. Biomarkers Prev. 17, 379\u2013386 (2008).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Irwin, M. L. et al. Influence of pre- and postdiagnosis physical activity on mortality in breast cancer survivors: the Health, Eating, Activity, and Lifestyle Study. J. Clin. Oncol. 26, 3958\u20133964 (2008).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Fortner, R. T. et al. Physical activity and breast cancer survival: results from the Nurses\u2019 Health Studies. JNCI Cancer Spectr. 7, pkac085 (2023).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Campbell, P. T., Patel, A. V., Newton, C. C., Jacobs, E. J. & Gapstur, S. M. Associations of recreational physical activity and leisure time spent sitting with colorectal cancer survival. J. Clin. Oncol. 31, 876\u2013885 (2013).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Kenfield, S. A., Stampfer, M. J., Giovannucci, E. & Chan, J. M. Physical Activity and survival after prostate cancer diagnosis in the health professionals follow-up study. J. Clin. Oncol. 29, 726\u2013732 (2011).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Wang, T. et al. Prediagnosis and postdiagnosis leisure time physical activity and survival following diagnosis with ovarian cancer. Int. J. Cancer 149, 1067\u20131075 (2021).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Hanyuda, A. et al. Survival benefit of exercise differs by tumor IRS1 Expression Status in Colorectal Cancer. Ann. Surg. Oncol. 23, 908\u2013917 (2016).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Courneya, K. S. et al. Effects of supervised exercise on progression-free survival in lymphoma patients: an exploratory follow-up of the HELP trial. Cancer Causes Control. 26, 269\u2013276 (2015).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Rundqvist, H., Rietz, M., Mijwel, S., Lindstr\u00f6m, L. S. & Wengstr\u00f6m, Y. Effects of a high-intensity exercise intervention on recurrence and survival: the OptiTrain breast cancer trial [abstract 232O]. Ann. Oncol. 35, S309 (2024).<\/p>\n

Article<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Iyengar, N. M. et al. Phase 1 trial of exercise as first-line therapy for hormone receptor (HR)-positive advanced breast cancer (TBCRC 054) [abstract]. J. Clin. Oncol. 43, 1088 (2025).<\/p>\n

Article<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Jones, L. W. et al. Modulation of circulating angiogenic factors and tumor biology by aerobic training in breast cancer patients receiving neoadjuvant chemotherapy. Cancer Prev. Res. 6, 925\u2013937 (2013).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Courneya, K. S. et al. Effects of aerobic and resistance exercise in breast cancer patients receiving adjuvant chemotherapy: a multicenter randomized controlled trial. J. Clin. Oncol. 25, 4396\u20134404 (2007).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Courneya, K. S. et al. Effects of exercise dose and type during breast cancer chemotherapy: multicenter randomized trial. J. Natl Cancer Inst. 105, 1821\u20131832 (2013).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

van Waart, H. et al. Effect of low-intensity physical activity and moderate- to high-intensity physical exercise during adjuvant chemotherapy on physical fitness, fatigue, and chemotherapy completion rates: results of the PACES randomized clinical trial. J. Clin. Oncol. 33, 1918\u20131927 (2015).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Carayol, M. et al. Short- and long-term impact of adapted physical activity and diet counseling during adjuvant breast cancer therapy: the \u201cAPAD1\u201d randomized controlled trial. BMC Cancer 19, 737 (2019).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Physical Activity Guidelines Advisory Committee. 2018 Physical Activity Guidelines Advisory Committee Scientific Report. US Department of Health and Human Services https:\/\/odphp.health.gov\/sites\/default\/files\/2019-09\/PAG_Advisory_Committee_Report.pdf<\/a> (2018).<\/p>\n

Li, Y. et al. Association between physical activity and all cancer mortality: dose\u2013response meta-analysis of cohort studies. Int. J. Cancer 138, 818\u2013832 (2016).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Li, T. et al. The dose\u2013response effect of physical activity on cancer mortality: findings from 71 prospective cohort studies. Br. J. Sports Med. 50, 339\u2013345 (2016).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Ju, J. et al. Voluntary exercise inhibits intestinal tumorigenesis in ApcMin\/+ mice and azoxymethane\/dextran sulfate sodium-treated mice. BMC Cancer 8, 316 (2008).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Higgins, K. A., Park, D., Lee, G. Y., Curran, W. J. & Deng, X. Exercise-induced lung cancer regression: mechanistic findings from a mouse model. Cancer 120, 3302\u20133310 (2014).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Goh, J. et al. Exercise training in transgenic mice is associated with attenuation of early breast cancer growth in a dose-dependent manner. PLoS ONE 8, e80123 (2013).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

MacVicar, M. G., Winningham, M. L. & Nickel, J. L. Effects of aerobic interval training on cancer patients\u2019 functional capacity. Nurs. Res. 38, 348\u2013351 (1989).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Alibhai, S. M. H. et al. A phase II exercise randomized controlled trial for patients with acute myeloid leukemia undergoing induction chemotherapy. Leuk. Res. 39, 1178\u20131186 (2015).<\/p>\n

Article<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n","protected":false},"excerpt":{"rendered":"Fink, H. et al. Global and regional cancer burden attributable to modifiable risk factors to inform prevention. Nat.…\n","protected":false},"author":2,"featured_media":795999,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[43],"tags":[82099,3250,102,2960,3249,28563,56,54,55],"class_list":["post-795998","post","type-post","status-publish","format-standard","has-post-thumbnail","category-healthcare","tag-cancer-epidemiology","tag-general","tag-health","tag-healthcare","tag-medicine-public-health","tag-oncology","tag-uk","tag-united-kingdom","tag-unitedkingdom"],"_links":{"self":[{"href":"https:\/\/www.newsbeep.com\/uk\/wp-json\/wp\/v2\/posts\/795998","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.newsbeep.com\/uk\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.newsbeep.com\/uk\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/uk\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/uk\/wp-json\/wp\/v2\/comments?post=795998"}],"version-history":[{"count":0,"href":"https:\/\/www.newsbeep.com\/uk\/wp-json\/wp\/v2\/posts\/795998\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/uk\/wp-json\/wp\/v2\/media\/795999"}],"wp:attachment":[{"href":"https:\/\/www.newsbeep.com\/uk\/wp-json\/wp\/v2\/media?parent=795998"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.newsbeep.com\/uk\/wp-json\/wp\/v2\/categories?post=795998"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.newsbeep.com\/uk\/wp-json\/wp\/v2\/tags?post=795998"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}