The notable difference in reversed aging adds evidence that the jabs and pills might be a true longevity treatment.<\/p>\n
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The makers of GLP-1s revealed the blockbuster weight loss drugs may also be a longevity treatment. Drobot Dean \u2013 stock.adobe.com<\/p>\n
More than one in 10 American adults<\/a> are on GLP-1s for weight loss, with the drugs working to shed pounds and provide a host of other<\/a> unexpected<\/a> benefits<\/a>.<\/p>\n Several factors, from our relationships<\/a> to lifestyle factors like smoking, diet, weight and health conditions<\/a>, can influence biological aging, or how our cells and organs age.<\/p>\n During the Aging Research & Drug Discovery conference<\/a>, the pharmaceutical companies shared their findings from several trials on the effects the medications have on aging.<\/p>\n And overweight or diabetic patients taking the medications saw a decreased age of around two or three years, a notable outcome according to one biological aging expert.<\/p>\n \u201cTwo years is a pretty strong effect, in my book,\u201d geneticist Steve Horvath, the inventor of aging clocks<\/a>, said, adding that the data suggests GLP-1 drugs \u201care actually what is known as geroprotectors, medications that slow or possibly even reverse biologic aging.\u201d<\/p>\n As part of their research, Novo took blood draws from 10,052 people, half on the drug semaglutide and half on a placebo.<\/p>\n The blood \u2014 collected at the start of the study as well as months later \u2014 was then measured with \u201cproteomic clocks,\u201d which use levels of key proteins to predict a person\u2019s age and risk of dying<\/a>.<\/p>\n Eli Lilly performed a similar, yet smaller, study on their drug, tirzepatide, using \u201cepigenetic\u201d clocks that measure age by marking changes to a person\u2019s DNA.<\/p>\n In the search for scientific remedies for aging, Novo\u2019s drug semaglutide (sold under the names Ozempic and Wegovy) may be the closest solution.<\/p>\n The difference in aging varied widely, depending on which type of clock was used and what organ was tested.<\/p>\n For example, the drugs slowed down aging as much as four years in the case of a clock that looked at heart proteins.<\/p>\n Overall, though, both studies found that the drugs slowed down molecular time in a significant way.<\/p>\n Multiple other studies<\/a> have shown that GLP-1s improve health metrics like high blood pressure and cholesterol through a combination of weight loss and weight-independent mechanisms, both of which also affect biological aging.<\/p>\n However, it\u2019s unclear whether they would have the same anti-aging effects on a healthy population as they did on patients with obesity or type 2 diabetes.<\/p>\n And while the medications do come with a host of side effects<\/a> and adverse events<\/a>, the research is pointing to a significant benefit in aging and longevity.<\/p>\n \u201cAll the clocks are telling a consistent story that we\u2019re seeing a reduction in age,\u201d vice president for aging research at Lilly, Kevin Duffin, said during the conference.<\/p>\n \u201cIt\u2019s not like we\u2019re going to reverse age by 30 years or something, but it\u2019s a significant reduction.\u201d<\/p>\n![\"A](\"https:\/\/www.newsbeep.com\/uk\/wp-content\/uploads\/2026\/10\/144635961.jpg\")
Eli Lilly and Novo Nordisk presented research that showed GLP-1s reversed biological aging by two to three years. Nunukuz \u2013 stock.adobe.com<\/p>\n