{"id":81037,"date":"2025-08-20T21:15:11","date_gmt":"2025-08-20T21:15:11","guid":{"rendered":"https:\/\/www.newsbeep.com\/uk\/81037\/"},"modified":"2025-08-20T21:15:11","modified_gmt":"2025-08-20T21:15:11","slug":"brain-stimulation-offers-hope-for-depression-fitness","status":"publish","type":"post","link":"https:\/\/www.newsbeep.com\/uk\/81037\/","title":{"rendered":"Brain stimulation offers hope for depression, fitness"},"content":{"rendered":"<p class=\"paragraph | gutter_20_0\">That might sound like science fiction, but researchers are increasingly finding that a low-level electrical current delivered by tiny electrodes applied to a person\u2019s scalp can be effective for treating a variety of health issues that don\u2019t fully respond to more traditional therapeutics or counseling.<\/p>\n<p class=\"paragraph | gutter_20_0\">Among the bevy of recent research into this approach, called <a href=\"https:\/\/www.nature.com\/articles\/s41598-023-29792-6\" target=\"_blank\" rel=\"nofollow noopener\" title=\"https:\/\/www.nature.com\/articles\/s41598-023-29792-6\">transcranial direct current stimulation<\/a>, is a small, proof-of-concept study from Boston scientists that found a combination of such <a href=\"https:\/\/www.bostonglobe.com\/2022\/08\/22\/metro\/few-electrical-zaps-may-boost-memory\/\" target=\"_blank\" rel=\"nofollow noopener\" title=\"https:\/\/www.bostonglobe.com\/2022\/08\/22\/metro\/few-electrical-zaps-may-boost-memory\/\">brain stimulation<\/a>, along with intermittent personalized coaching on health and fitness, significantly increased physical activity in older adults. It boosted their daily step count an average of 1,179 steps per day.<\/p>\n<p class=\"paragraph | gutter_20_0\">The results held steady for up to three months after the stimulation and coaching ended. <\/p>\n<p class=\"paragraph | gutter_20_0\">\u201cOne person had 3,000 daily steps in the beginning of the study, but she improved to 10,000 steps in the end,\u201d said <a href=\"https:\/\/urldefense.com\/v3\/__https:\/\/www.marcusinstituteforaging.org\/who-we-are\/profiles\/yee-amy-lo-phd__;!!BspMT6SJLSDJ!M_23YfDA_xrXgKamWJK6TidnJ-Tj8czi96--IezDF3mcbn1K0NNxAeCQFKgJykTAYtIyKJaygu4yFnN2teksd6oHvNerlqU$\" target=\"_blank\" rel=\"nofollow noopener\">On-Yee Lo <\/a>, an assistant scientist at the <a href=\"https:\/\/urldefense.com\/v3\/__https:\/\/www.marcusinstituteforaging.org\/__;!!BspMT6SJLSDJ!M_23YfDA_xrXgKamWJK6TidnJ-Tj8czi96--IezDF3mcbn1K0NNxAeCQFKgJykTAYtIyKJaygu4yFnN2teksd6oHoOFb7o0$\" target=\"_blank\" rel=\"nofollow noopener\">Hinda and Arthur Marcus Institute for Aging Research<\/a> at Hebrew SeniorLife, and the study\u2019s lead author.<\/p>\n<p class=\"paragraph | gutter_20_0\">The 10,000-stepper told researchers she felt like she got her \u201cexercise high\u201d back, Lo said.<\/p>\n<p class=\"paragraph | gutter_20_0\">\u201cBut I have to say,\u201d Lo added, \u201cthis is not everyone that has this superstar type of behavior.\u201d<\/p>\n<p class=\"paragraph | gutter_20_0\">Lo\u2019s team studied 28 older adults, ranging in age from 67 to 94 years old, with more than half 80 or older. All but three were women, and all were living in subsidized housing. The setting was chosen because older adults, particularly in subsidized housing, often don\u2019t have easy access to exercise facilities and may be less motivated to work out.<\/p>\n<p class=\"paragraph | gutter_20_0\">The participants received the counseling and the brain stimulation at home, an attempt to remove barriers to treatment. The stimulation was delivered in ten 20-minute sessions over two weeks, and counseling was provided four times over two weeks.<\/p>\n<p class=\"paragraph | gutter_20_0\">Both groups received counseling, but only half received the brain stimulation, which used a current as low as you\u2019d find in a home smoke detector. The other half received a placebo: a similar cap that delivered a tingling sensation but didn\u2019t include electrical current.<\/p>\n<p class=\"paragraph | gutter_20_0\">The group that received the electrical stimulation increased their step count by more than twice the increase seen in those who received placebo, Lo said.<\/p>\n<p class=\"paragraph | gutter_20_0\">The researchers stimulated participants\u2019 left front portion of the brain, known as the prefrontal cortex, what Lo calls the \u201dCEO of our brain,&#8221; because it\u2019s more directly linked to problem solving and directing physical behavior.<\/p>\n<p><img decoding=\"async\" id=\"img-XFPCGWGCHXEXFE6TFOFLRRFHJM-image\" alt=\"Mimi Katz , an  87-year old Brookline resident, recently participated in a trial aimed at increasing exercise among older adults  by using brain stimulation at her home.\" class=\"height_a width_full invisible width_full--mobile width_full--tablet-only\" src=\"https:\/\/www.newsbeep.com\/uk\/wp-content\/uploads\/2025\/08\/XFPCGWGCHXEXFE6TFOFLRRFHJM.jpg\"  loading=\"lazy\"\/>Mimi Katz , an  87-year old Brookline resident, recently participated in a trial aimed at increasing exercise among older adults  by using brain stimulation at her home.David L Ryan\/ Globe Staff<\/p>\n<p class=\"paragraph | gutter_20_0\">Among the participants who received the electrical stimulation was 87-year-old Mimi Katz, a Brookline resident who doesn\u2019t recall feeling any tingling sensations, but one memory is crystal clear.<\/p>\n<p class=\"paragraph | gutter_20_0\">\u201cAfter the first [brain stimulation session], I thought, yes I am going to exercise. There is not a doubt in my mind,\u201d Katz recalled.<\/p>\n<p class=\"paragraph | gutter_20_0\">Katz is the \u201csuperstar\u201d participant who increased her daily steps to about 10,000 daily for weeks after the study. She\u2019s still walking, though not sure if it\u2019s as much as before. The only downside to the electrical stimulation, she said, was the gel they put on her scalp where the electrodes were placed.<\/p>\n<p class=\"paragraph | gutter_20_0\">\u201cThey have to put all this gunk on so the electrodes stick, which means you have to wash your hair after every treatment,\u201d she said. \u201cBut that\u2019s not terrible.\u201d<\/p>\n<p><img decoding=\"async\" id=\"img-BQWICXFQWDLKESHTEPCIZ46EB4-image\" alt=\"Mimi Katz took a self-portrait from her cellphone of her wearing a brain stimulation device when she participated in a recent trial testing electrical brain stimulation to increase motivation for working out among older adults.\" class=\"height_a width_full invisible width_full--mobile width_full--tablet-only\" src=\"https:\/\/www.newsbeep.com\/uk\/wp-content\/uploads\/2025\/08\/BQWICXFQWDLKESHTEPCIZ46EB4.jpg\"  loading=\"lazy\"\/>Mimi Katz took a self-portrait from her cellphone of her wearing a brain stimulation device when she participated in a recent trial testing electrical brain stimulation to increase motivation for working out among older adults.David L Ryan\/ Globe Staff<\/p>\n<p class=\"paragraph | gutter_20_0\">While electrical stimulation research is gaining steam, <a href=\"https:\/\/www.bostonglobe.com\/lifestyle\/2016\/04\/18\/tracking-risks-and-rewards-transcranial-magnetic-stimulation\/VrM0JhIpWgMPDXe2sbyFpI\/story.html\" target=\"_blank\" rel=\"nofollow noopener\" title=\"https:\/\/www.bostonglobe.com\/lifestyle\/2016\/04\/18\/tracking-risks-and-rewards-transcranial-magnetic-stimulation\/VrM0JhIpWgMPDXe2sbyFpI\/story.html\">an older cousin to it<\/a> \u2014 <a href=\"https:\/\/www.fda.gov\/news-events\/press-announcements\/fda-permits-marketing-transcranial-magnetic-stimulation-treatment-obsessive-compulsive-disorder\" target=\"_blank\" rel=\"nofollow noopener\" title=\"https:\/\/www.fda.gov\/news-events\/press-announcements\/fda-permits-marketing-transcranial-magnetic-stimulation-treatment-obsessive-compulsive-disorder\">magnetic brain stimulation <\/a>\u2014 was approved by federal regulators for clinical use to treat major depression 17 years ago. It has since been cleared for other uses, including for treatment of migraine headaches and obsessive-compulsive disorder.<\/p>\n<p class=\"paragraph | gutter_20_0\">Electrical stimulation, a newer field of research, has not yet received federal clearance for clinical use.<\/p>\n<p class=\"paragraph | gutter_20_0\">Researchers say both electrical and <a href=\"https:\/\/www.bostonglobe.com\/magazine\/2018\/02\/20\/how-science-fixed-wandering-mind\/mNGWEabvxGQWO1rUK7i7UJ\/story.html\" target=\"_blank\" rel=\"nofollow noopener\" title=\"https:\/\/www.bostonglobe.com\/magazine\/2018\/02\/20\/how-science-fixed-wandering-mind\/mNGWEabvxGQWO1rUK7i7UJ\/story.html\">magnetic stimulation<\/a>, which applies magnetic pulses to the scalp, stimulate nerve cells in the brain, called neurons.<\/p>\n<p class=\"paragraph | gutter_20_0\"><a href=\"https:\/\/hsph.harvard.edu\/exec-ed\/faculty\/felipe-fregni\/\" target=\"_blank\" rel=\"nofollow noopener\" title=\"https:\/\/hsph.harvard.edu\/exec-ed\/faculty\/felipe-fregni\/\">Dr. Felipe Fregni<\/a>, a professor of Physical Medicine and Rehabilitation at Harvard Medical School, said stimulating such nerve cells seems to be a more effective approach for treating chronic pain, such as with fibromyalgia, rather than trying to dull the pain with analgesic medications.<\/p>\n<p class=\"paragraph | gutter_20_0\">That\u2019s because an analgesic can have a boomerang effect, he said, at first decreasing nerve signals. But then a patient\u2019s neurons try to react to that, and fire up again.<\/p>\n<p class=\"paragraph | gutter_20_0\">But stimulating neurons, Fregni said, seems to help regulate chronic pain by initially overactivating the neurons involved in pain processing, and then the neurons relax, bringing down the pain circuit.<\/p>\n<p class=\"paragraph | gutter_20_0\">His <a href=\"https:\/\/jamanetwork.com\/journals\/jamanetworkopen\/fullarticle\/2835058\" target=\"_blank\" rel=\"nofollow noopener\" title=\"https:\/\/jamanetwork.com\/journals\/jamanetworkopen\/fullarticle\/2835058\">recent study <\/a>used electrical brain stimulation, along with exercise, and pain education for 112 women with fibromyalgia, and found the approach effective for helping to manage pain. The researchers taught the participants how to operate the brain stimulation device at home, and they were instructed to do this five times a week for four weeks. <\/p>\n<p class=\"paragraph | gutter_20_0\">Fregni said the pain relief benefits started to decrease four weeks after the treatments ended.<\/p>\n<p class=\"paragraph | gutter_20_0\">\u201cWhatever is causing fibromyalgia, [brain stimulation] is not reaching the cause of whatever may lead to dysfunction in brain plasticity,\u201d he said. The stimulation \u201cis trying to balance the plasticity, trying to create an environment to better decrease pain, but whatever is causing it is still there.\u201d<\/p>\n<p class=\"paragraph | gutter_20_0\"><a href=\"https:\/\/med.uth.edu\/psychiatry\/2022\/11\/11\/rodrigo-machado-vieira-md-phd-msc\/\" target=\"_blank\" rel=\"nofollow noopener\" title=\"https:\/\/med.uth.edu\/psychiatry\/2022\/11\/11\/rodrigo-machado-vieira-md-phd-msc\/\">Dr. Rodrigo Machado-Vieira<\/a>, a psychiatry professor at the McGovern Medical School at <a href=\"https:\/\/www.uthouston.edu\/\" target=\"_blank\" rel=\"nofollow noopener\"> UTHealth Houston<\/a>, was lead researcher in a <a href=\"https:\/\/www.nature.com\/articles\/s41591-024-03305-y\" target=\"_blank\" rel=\"nofollow noopener\" title=\"https:\/\/www.nature.com\/articles\/s41591-024-03305-y\">study published last year<\/a> involving 174 adults with moderate to severe depression.<\/p>\n<p class=\"paragraph | gutter_20_0\">They were randomly assigned to one of two treatment groups: electrical brain stimulation, or inactive stimulation, which used the same device but did not provide a current. Participants were taught how to use the device at home and followed a 10-week course of treatment. Those who received the electrical stimulation showed significant improvements in the severity of their depression, compared to those who used the inactive device.<\/p>\n<p class=\"paragraph | gutter_20_0\">Machado-Vieira said some patients respond better to electrical versus magnetic stimulation, and vice-versa, but researchers still don\u2019t understand why. One benefit of electrical rather than magnetic, however, is that the electrical devices being tested now are much smaller and lighter than the magnetic ones typically only used in doctors\u2019 offices. <\/p>\n<p class=\"paragraph | gutter_20_0\">Machado-Vieira and other scientists said getting federal regulators to approve small electrical stimulation devices that can be used at home would make the treatment more widely accessible.<\/p>\n<p class=\"paragraph | gutter_20_0\">\u201cIn terms of convenience for people who live far away, or who cannot travel to sessions at the clinic, that\u2019s a clear advantage of the [electrical devices], but that doesn\u2019t mean that they are going to respond better to that,\u201d compared to magnetic stimulation, he said.<\/p>\n<p class=\"paragraph | gutter_20_0\">Machado-Vieira also said brain stimulation alone, without medications, is probably not powerful enough to treat major depression. But he understands as a clinician who has long treated patients, that some just won\u2019t stick with their medications.<\/p>\n<p class=\"paragraph | gutter_20_0\"> \u201cPsychiatric medications have some level of stigma,\u201d he said. \u201cThere are some groups of patients who really are not willing to take antidepressants and would benefit from this [brain stimulation] type of intervention.\u201d <\/p>\n<p class=\"tagline | font_primary inline_block  margin_top_32\">Kay Lazar can be reached at <a href=\"https:\/\/www.bostonglobe.com\/2025\/08\/19\/metro\/electric-brain-stimulation-exercise-weight-depression\/mailto:kay.lazar@globe.com\" class=\"\" target=\"_blank\" style=\"font-size:inherit;letter-spacing:.5px\" rel=\"nofollow noopener\">kay.lazar@globe.com<\/a> Follow her <a href=\"https:\/\/www.twitter.com\/GlobeKayLazar\" class=\"\" target=\"_blank\" style=\"font-size:inherit;letter-spacing:.5px\" rel=\"nofollow noopener\">@GlobeKayLazar<\/a>.<\/p>\n<p><script async src=\"https:\/\/platform.twitter.com\/widgets.js\" charset=\"utf-8\"><\/script><\/p>\n","protected":false},"excerpt":{"rendered":"That might sound like science fiction, but researchers are increasingly finding that a low-level electrical current delivered by&hellip;\n","protected":false},"author":2,"featured_media":81038,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[46],"tags":[6647,102,56,54,55],"class_list":{"0":"post-81037","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-fitness","8":"tag-fitness","9":"tag-health","10":"tag-uk","11":"tag-united-kingdom","12":"tag-unitedkingdom"},"_links":{"self":[{"href":"https:\/\/www.newsbeep.com\/uk\/wp-json\/wp\/v2\/posts\/81037","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.newsbeep.com\/uk\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.newsbeep.com\/uk\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/uk\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/uk\/wp-json\/wp\/v2\/comments?post=81037"}],"version-history":[{"count":0,"href":"https:\/\/www.newsbeep.com\/uk\/wp-json\/wp\/v2\/posts\/81037\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/uk\/wp-json\/wp\/v2\/media\/81038"}],"wp:attachment":[{"href":"https:\/\/www.newsbeep.com\/uk\/wp-json\/wp\/v2\/media?parent=81037"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.newsbeep.com\/uk\/wp-json\/wp\/v2\/categories?post=81037"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.newsbeep.com\/uk\/wp-json\/wp\/v2\/tags?post=81037"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}