{"id":811338,"date":"2026-10-23T10:34:13","date_gmt":"2026-10-23T10:34:13","guid":{"rendered":"https:\/\/www.newsbeep.com\/uk\/811338\/"},"modified":"2026-10-23T10:34:13","modified_gmt":"2026-10-23T10:34:13","slug":"first-personalised-cancer-vaccine-cuts-risk-of-disease-returning-in-major-trial","status":"publish","type":"post","link":"https:\/\/www.newsbeep.com\/uk\/811338\/","title":{"rendered":"First personalised cancer vaccine cuts risk of disease returning in major trial"},"content":{"rendered":"<p class=\"ssrcss-1q0x1qg-Paragraph e1jhz7w10\">Shares in the drugmakers MSD (known as Merck in the US) and Moderna have surged since both companies first hinted at the success of the vaccine in the summer.<\/p>\n<p class=\"ssrcss-1q0x1qg-Paragraph e1jhz7w10\">But investors sold off stock on Thursday after financial analysts said the results were not quite as strong as those seen in an earlier, much smaller trial.<\/p>\n<p class=\"ssrcss-1q0x1qg-Paragraph e1jhz7w10\">Both companies said they were now &#8220;engaging with authorities&#8221; suggesting they could file for approval from medicine regulators as soon as next year.<\/p>\n<p class=\"ssrcss-1q0x1qg-Paragraph e1jhz7w10\">Widespread NHS use will also depend on cost, given that each individual patient will need to have their tumour genetically analysed and a personalised vaccine made for them.<\/p>\n<p class=\"ssrcss-1q0x1qg-Paragraph e1jhz7w10\">The trial will continue so that the patients involved can be monitored \u2013 both to see if the cancer returns over time and to assess whether the drug ultimately helps them live longer.<\/p>\n<p class=\"ssrcss-1q0x1qg-Paragraph e1jhz7w10\">Professor Alan Melcher from the Institute of Cancer Research in London, who wasn&#8217;t involved in the research, described the results as &#8220;very impressive&#8221;.<\/p>\n<p class=\"ssrcss-1q0x1qg-Paragraph e1jhz7w10\">&#8220;It is an important proof of principle for the field, although we shouldn&#8217;t get ahead of the evidence,&#8221; he said.<\/p>\n<p class=\"ssrcss-1q0x1qg-Paragraph e1jhz7w10\">&#8220;We can&#8217;t assume from one melanoma trial that the same approach will work across all cancers, and longer follow-up will be important to understand the effect on overall survival.&#8221;<\/p>\n<p class=\"ssrcss-1q0x1qg-Paragraph e1jhz7w10\">The full trial results are due to be presented at the European Society of Medical Oncology (ESMO) cancer conference in Madrid on Saturday. <\/p>\n<p class=\"ssrcss-1q0x1qg-Paragraph e1jhz7w10\">They have yet to be published in a peer-reviewed medical journal, where they can be scrutinised by independent experts.<\/p>\n","protected":false},"excerpt":{"rendered":"Shares in the drugmakers MSD (known as Merck in the US) and Moderna have surged since both companies&hellip;\n","protected":false},"author":2,"featured_media":811339,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[5],"tags":[84,59,56,54,55],"class_list":["post-811338","post","type-post","status-publish","format-standard","has-post-thumbnail","category-business","tag-business","tag-gb","tag-uk","tag-united-kingdom","tag-unitedkingdom"],"_links":{"self":[{"href":"https:\/\/www.newsbeep.com\/uk\/wp-json\/wp\/v2\/posts\/811338","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.newsbeep.com\/uk\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.newsbeep.com\/uk\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/uk\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/uk\/wp-json\/wp\/v2\/comments?post=811338"}],"version-history":[{"count":0,"href":"https:\/\/www.newsbeep.com\/uk\/wp-json\/wp\/v2\/posts\/811338\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/uk\/wp-json\/wp\/v2\/media\/811339"}],"wp:attachment":[{"href":"https:\/\/www.newsbeep.com\/uk\/wp-json\/wp\/v2\/media?parent=811338"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.newsbeep.com\/uk\/wp-json\/wp\/v2\/categories?post=811338"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.newsbeep.com\/uk\/wp-json\/wp\/v2\/tags?post=811338"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}