{"id":85588,"date":"2025-08-22T18:08:08","date_gmt":"2025-08-22T18:08:08","guid":{"rendered":"https:\/\/www.newsbeep.com\/uk\/85588\/"},"modified":"2025-08-22T18:08:08","modified_gmt":"2025-08-22T18:08:08","slug":"association-of-tnf-and-tlr2-genes-with-blood-parameter-levels-in-mexican-patients-with-schizophrenia-bmc-psychiatry","status":"publish","type":"post","link":"https:\/\/www.newsbeep.com\/uk\/85588\/","title":{"rendered":"Association of TNF and TLR2 genes with blood parameter levels in Mexican patients with schizophrenia | BMC Psychiatry"},"content":{"rendered":"

Jablensky A. Schizophrenia in DSM-5: assets and liabilities. Schizophr Res. 2013;150(1):36\u20137. https:\/\/doi.org\/10.1016\/j.schres.2013.07.037<\/a>.<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Ermakov EA, Melamud MM, Buneva VN, Ivanova SA. Immune system abnormalities in schizophrenia: an integrative view and translational perspectives. Front Psychiatry. 2022;13:880568. https:\/\/doi.org\/10.3389\/fpsyt.2022.880568<\/a>.<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Dudeck L, Nussbaumer M, Nickl-Jockschat T, Guest PC, Dobrowolny H, Meyer-Lotz G, Zhao Z, Jacobs R, Schiltz K, Fernandes BS, Steiner J. Differences in blood leukocyte subpopulations in schizophrenia: A systematic review and Meta-Analysis. JAMA Psychiatry. 2025;82(5):492\u2013504. https:\/\/doi.org\/10.1001\/jamapsychiatry.2024.4941<\/a>.<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Clausen M, Christensen RHB, da Re M, Benros ME. Immune cell alterations in psychotic disorders: A comprehensive systematic review and Meta-Analysis. Biol Psychiatry. 2024;96(5):331\u201341. https:\/\/doi.org\/10.1016\/j.biopsych.2023.11.029<\/a>.<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Chen CY, Shih YC, Hung YF, Hsueh YP. Beyond defense: regulation of neuronal morphogenesis and brain functions via Toll-like receptors. J Biomed Sci. 2019;26(1):90. https:\/\/doi.org\/10.1186\/s12929-019-0584-z<\/a>.<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Maouia A, Rebetz J, Kapur R, Semple JW. The immune nature of platelets revisited. Transfus Med Rev. 2020;34(4):209\u201320. https:\/\/doi.org\/10.1016\/j.tmrv.2020.09.005<\/a>.<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Sansanayudh N, Anothaisintawee T, Muntham D, McEvoy M, Attia J, Thakkinstian A. Mean platelet volume and coronary artery disease: a systematic review and meta-analysis. Int J Cardiol. 2014;175(3):433\u201340. https:\/\/doi.org\/10.1016\/j.ijcard.2014.06.028<\/a>.<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Hartmann LT, Alegretti AP, Machado ABMP, Martins EF, da Silva Chakr RM, Gasparin AA, Monticielo OA. Assessment of mean platelet volume in patients with systemic lupus erythematosus. Open Rheumatol J. 2018;12:129\u201338. https:\/\/doi.org\/10.2174\/1874312901812010129<\/a>.<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Asor E, Ben-Shachar D, Platelets. A possible glance into brain biological processes in schizophrenia. World J Psychiat. 2012;2(6):124\u201333. https:\/\/doi.org\/10.5498\/wjp.v2.i6.124<\/a>.<\/p>\n

Article<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Jarari AM, Peela JR, Zakoko A, Hawda S, Abd El Rasoul H, Peela AST, Addagarla S, Madompoyil B. The role of antipsychotic medications on metabolic and hematological parameters. Cureus. 2025;17(4):e82293. https:\/\/doi.org\/10.7759\/cureus.82293<\/a>.<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Chen Z, Wang J, Carru C, Sedda S, Nivoli AM, Li Z. Meta-analysis of peripheral mean platelet volume in patients with mental disorders: comparisons in depression, anxiety, bipolar disorder, and schizophrenia. Brain Behav. 2023;13(11):e3240. https:\/\/doi.org\/10.1002\/brb3.3240<\/a>.<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Alm\u0131\u015f BH, E\u011filmez OB. Platelet parameters in First-Episode patients with schizophrenia and bipolar disorder. Psychiat Clin Psychopharmacol. 2021;31(3):339\u201343. https:\/\/doi.org\/10.5152\/pcp.2021.21695<\/a>.<\/p>\n

Article<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Zhang Y, Zheng Y, Ni P, Liang S, Li X, Yu H, Wei W, Qi X, Yu X, Xue R, Zhao L, Deng W, Wang Q, Guo W, Li T. New role of platelets in schizophrenia: predicting drug response. Gen Psychiat. 2024;37(2):e101347. https:\/\/doi.org\/10.1136\/gpsych-2023-101347<\/a>.<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Cabello-Rangel H, Basurto-Morales M, Botello-Aceves E, Pazar\u00e1n-Galicia O. Mean platelet volume, platelet count, and neutrophil\/lymphocyte ratio in drug-na\u00efve patients with schizophrenia: a cross-sectional study. Front Psychiat. 2023;14:1150235. https:\/\/doi.org\/10.3389\/fpsyt.2023.1150235<\/a>.<\/p>\n

Article<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Ali E, Embaby A, Ibrahim D. Mean platelet volumen, red cell distribution width, and lymphocyte ratios as surrogate predictors of subclinical inflammation in schizophrenia: A cross-sectional study. EuroMediterranean Biomed J. 2022;17(39):181\u20135.<\/p>\n


\n Google Scholar<\/a>\u00a0\n <\/p>\n

Johnson AD. The genetics of common variation affecting platelet development, function and pharmaceutical targeting. J Thromb Haemost. 2011;9(Suppl 1):246\u201357. https:\/\/doi.org\/10.1111\/j.1538-7836.2011.04359.x<\/a>.<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

O\u2019Donnell CJ, Larson MG, Feng D, Sutherland PA, Lindpaintner K, Myers H, D\u2019Agostino RA, Levy D, Tofler GH. Framingham heart study. Genetic and environmental contributions to platelet aggregation: the Framingham heart study. Circulation. 2001;103(25):3051\u20136. https:\/\/doi.org\/10.1161\/01.cir.103.25.3051<\/a>.<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Schick UM, Jain D, Hodonsky CJ, Morrison JV, Davis JP, Brown L, Sofer T, Conomos MP, Schurmann C, McHugh CP, Nelson SC, Vadlamudi S, Stilp A, Plantinga A, Baier L, Bien SA, Gogarten SM, Laurie CA, Taylor KD, Liu Y, Reiner AP. Genome-wide association study of platelet count identifies Ancestry-Specific loci in hispanic\/latino Americans. Am J Hum Genet. 2016;98(2):229\u201342. https:\/\/doi.org\/10.1016\/j.ajhg.2015.12.003<\/a>.<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Astle WJ, Elding H, Jiang T, Allen D, Ruklisa D, Mann AL, Mead D, Bouman H, Riveros-Mckay F, Kostadima MA, Lambourne JJ, Sivapalaratnam S, Downes K, Kundu K, Bomba L, Berentsen K, Bradley JR, Daugherty LC, Delaneau O, Freson K. Soranzo N. The allelic landscape of human blood cell trait variation and links to common complex disease. Cell. 2016;167(5):1415\u201329. https:\/\/doi.org\/10.1016\/j.cell.2016.10.042<\/a>.<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Eicher JD, Chami N, Kacprowski T, Nomura A, Chen MH, Yanek LR, Tajuddin SM, Schick UM, Slater AJ, Pankratz N, Polfus L, Schurmann C, Giri A, Brody JA, Lange LA, Manichaikul A, Hill WD, Pazoki R, Elliot P, Evangelou E. Johnson AD. Platelet-Related variants identified by exomechip Meta-analysis in 157,293 individuals. Am J Hum Genet. 2016;99(1):40\u201355. https:\/\/doi.org\/10.1016\/j.ajhg.2016.05.005<\/a>.<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Gieger C, Radhakrishnan A, Cvejic A, Tang W, Porcu E, Pistis G, Serbanovic-Canic J, Elling U, Goodall AH, Labrune Y, Lopez LM, M\u00e4gi R, Meacham S, Okada Y, Pirastu N, Sorice R, Teumer A, Voss K, Zhang W, Ramirez-Solis R. Soranzo N. New gene functions in megakaryopoiesis and platelet formation. Nature. 2011;480(7376):201\u20138. https:\/\/doi.org\/10.1038\/nature10659<\/a>.<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Meisinger C, Prokisch H, Gieger C, Soranzo N, Mehta D, Rosskopf D, Lichtner P, Klopp N, Stephens J, Watkins NA, Deloukas P, Greinacher A, Koenig W, Nauck M, Rimmbach C, V\u00f6lzke H, Peters A, Illig T, Ouwehand WH, Meitinger T. D\u00f6ring A. A genome-wide association study identifies three loci associated with mean platelet volume. Am J Hum Genet. 2009;84(1):66\u201371. https:\/\/doi.org\/10.1016\/j.ajhg.2008.11.015<\/a>.<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Soranzo N, Spector TD, Mangino M, K\u00fchnel B, Rendon A, Teumer A, Willenborg C, Wright B, Chen L, Li M, Salo P, Voight BF, Burns P, Laskowski RA, Xue Y, Menzel S, Altshuler D, Bradley JR, Bumpstead S, Burnett MS. Gieger C. A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the haemgen consortium. Nat Genet. 2009;41(11):1182\u201390. https:\/\/doi.org\/10.1038\/ng.467<\/a>.<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Soranzo N, Rendon A, Gieger C, Jones CI, Watkins NA, Menzel S, D\u00f6ring A, Stephens J, Prokisch H, Erber W, Potter SC, Bray SL, Burns P, Jolley J, Falchi M, K\u00fchnel B,Erdmann J, Schunkert H, Samani NJ, Illig T, Ouwehand WH. A novel variant on chromosome 7q22.3 associated with mean platelet volume, counts, and function. Blood. 2009;113(16):3831\u201337. https:\/\/doi.org\/10.1182\/blood-2008-10-184234<\/a>.<\/p>\n

Lin JR, Cai Y, Zhang Q, Zhang W, Nogales-Cadenas R, Zhang ZD. Integrated Post-GWAS analysis sheds new light on the disease mechanisms of schizophrenia. Genetics. 2016;204(4):1587\u2013600. https:\/\/doi.org\/10.1534\/genetics.116.187195<\/a>.<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Bocchio Chiavetto L, Boin F, Zanardini R, Popoli M, Michelato A, Bignotti S, Tura GB, Gennarelli M. Association between promoter polymorphic haplotypes of interleukin-10 gene and schizophrenia. Biol Psychiat. 2002;51(6):480\u20134. https:\/\/doi.org\/10.1016\/s0006-3223(01)01324-5<\/a>.<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Qin H, Zhang L, Xu G, Pan X. Lack of association between TNF\u03b1 rs1800629 polymorphism and schizophrenia risk: a meta-analysis. Psychiatry Res. 2013;209(3):314\u20139. https:\/\/doi.org\/10.1016\/j.psychres.2013.01.019<\/a>.<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

He S, Zhang L, Yu S, Yu W, Yu Y, Huang J, Li H. Association between tumor necrosis factor-Alpha (TNF-a) polymorphisms and schizophrenia: an updated meta-analysis. Int J Psychiatry Clin Pract. 2022;26(3):294\u2013302. https:\/\/doi.org\/10.1080\/13651501.2021.2009879<\/a>.<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Kang N, Shin W, Jung S, Bang M, Lee SH. The effect of TNF-alpha rs1800629 polymorphism on white matter structures and memory function in patients with schizophrenia: A pilot study. Psychiatry Investig. 2022;19(12):1027\u201336. https:\/\/doi.org\/10.30773\/pi.2021.0326<\/a>.<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Alfimova MV, Korovaitseva GI, Gabaeva MV, Plakunova VV, Lezheiko TV, Golimbet VE. Genetic polymorphism of cytokines IL-1\u03b2, IL-4 and TNF-\u03b1 as a factor modifying the impact of childhood adversity on schizophrenia symptoms. Zh Nevrol Psikhiatr Im SS Korsakova. 2022;122(9):110\u20137. https:\/\/doi.org\/10.17116\/jnevro2022122091110<\/a>.<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Sotelo-Ram\u00edrez CE, Camarena B, Sanabrais-Jim\u00e9nez MA, Zaragoza-Hoyo JU, Ordo\u00f1ez-Mart\u00ednez B, Escamilla-Orozco RI, G\u00f3mez-Gonz\u00e1lez B. Toll-Like receptor (TLR) 1, 2, and 6 gene polymorphisms support evidence of innate immune factors in schizophrenia. Neuropsychiat Dis Treat. 2023;19:2353\u201361. https:\/\/doi.org\/10.2147\/NDT.S420952<\/a>.<\/p>\n

Article<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Mikhalitskaya EV, Vyalova NM, Ermakov EA, Levchuk LA, Simutkin GG, Bokhan NA, Ivanova SA. Association of single nucleotide polymorphisms of cytokine genes with depression, schizophrenia and bipolar disorder. Genes. 2023;14(7):1460. https:\/\/doi.org\/10.3390\/genes14071460<\/a>.<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Gonz\u00e1lez-Castro TB, Alfonso Tovilla-Z\u00e1rate C, Esther Ju\u00e1rez-Rojop I, Hern\u00e1ndez-D\u00edaz Y, Lilia L\u00f3pez-Narv\u00e1ez M, Felicita Ortiz-Ojeda R. The association of cytokines genes (IL-6 and IL-10) with the susceptibility to schizophrenia: A systematic review and meta-analysis. Brain Res. 2024;1822:148667. https:\/\/doi.org\/10.1016\/j.brainres.2023.148667<\/a>.<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Dastjerdi G, Fallahpour B, Dastgheib SA, Shahbazi A, Tafti AG, Bahrami M, Masoudi A, Shiri A, Nematzadeh F, Neamatzadeh H. Large-Scale Meta-Analysis of TNF-\u03b1 rs1800629 polymorphism in schizophrenia: evidence from 7,624 cases and 8,933 controls. Medeni Med J. 2025;40(2):80\u201392. https:\/\/doi.org\/10.4274\/MMJ.galenos.2025.72273<\/a>.<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Orbe EB, Benros ME. Immunological biomarkers as predictors of treatment response in psychotic disorders. J Pers Med. 2023;13(9):1382. https:\/\/doi.org\/10.3390\/jpm13091382<\/a>.<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Garc\u00eda-Bueno B, Bioque M, Mac-Dowell KS, Barcones MF, Mart\u00ednez-Cengotitabengoa M, Pina Camacho L, Rodr\u00edguez-Jim\u00e9nez R, S\u00e1iz PA, Castro C, Lafuente A, Santab\u00e1rbara J, Gonz\u00e1lez-Pinto A, Parellada M, Rubio G, Garc\u00eda-Portilla MP, Mic\u00f3 JA, Bernardo M, Leza JC. Pro-\/anti-inflammatory dysregulation in patients with first episode of psychosis: toward an integrative inflammatory hypothesis of schizophrenia. Schizophr Bull. 2014;40(2):376\u201387. https:\/\/doi.org\/10.1093\/schbul\/sbt001<\/a>.<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Goldsmith DR, Rapaport MH, Miller BJ. A meta-analysis of blood cytokine network alterations in psychiatric patients: comparisons between schizophrenia, bipolar disorder and depression. Mol Psychiatr. 2016;21(12):1696\u2013709. https:\/\/doi.org\/10.1038\/mp.2016.3<\/a>.<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Laskaris LE, Di Biase MA, Everall I, Chana G, Christopoulos A, Skafidas E, Cropley VL, Pantelis C. Microglial activation and progressive brain changes in schizophrenia. Br J Pharmacol. 2016;173(4):666\u201380. https:\/\/doi.org\/10.1111\/bph.13364<\/a>.<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Reyes-Lizaola S, Luna-Zarate U, Tendilla-Beltr\u00e1n H, Morales-Medina JC, Flores G. Structural and biochemical alterations in dendritic spines as key mechanisms for severe mental illnesses. Prog Neuropsychopharmacol Biol Psychiatry. 2024;129:110876. https:\/\/doi.org\/10.1016\/j.pnpbp.2023.110876<\/a>.<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Sotelo-Ram\u00edrez CE, Vald\u00e9s-Tovar M, Zaragoza-Hoyos JU, Ortiz-L\u00f3pez L, Argueta J, Rosel-Vales M, Miranda-Labra RU, Camarena B. Molecular and functional analysis of TLR 1, 2 and 6 in peripheral blood monocytes of patients with schizophrenia: A pilot study. Int J Mol Sci. 2025;26(3):926. https:\/\/doi.org\/10.3390\/ijms26030926<\/a>.<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Motsinger AA, Ritchie MD. Multifactor dimensionality reduction: an analysis strategy for modelling and detecting gene-gene interactions in human genetics and pharmacogenomics studies. Hum Genomics. 2006;2(5):318\u201328. https:\/\/doi.org\/10.1186\/1479-7364-2-5-318<\/a>.<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Khandaker GM, Dantzer R, Jones PB. Immunopsychiatry: important facts. Psychol Med. 2017;47(13):2229\u201337. https:\/\/doi.org\/10.1017\/S0033291717000745<\/a>.<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Feigenson KA, Kusnecov AW, Silverstein SM. Inflammation and the two-hit hypothesis of schizophrenia. Neurosci Biobehav Rev. 2014;38:72\u201393. https:\/\/doi.org\/10.1016\/j.neubiorev.2013.11.006<\/a>.<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Avramopoulos D, Pearce BD, McGrath J, Wolyniec P, Wang R, Eckart N, Hatzimanolis A, Goes FS, Nestadt G, Mulle J, Coneely K, Hopkins M, Ruczinski I, Yolken R, Pulver AE. Infection and inflammation in schizophrenia and bipolar disorder: a genome wide study for interactions with genetic variation. PLoS ONE. 2015;10(3):e0116696. https:\/\/doi.org\/10.1371\/journal.pone.0116696<\/a>.<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Butkiewicz AM, Kemona H, Dymicka-Piekarska V, Matowicka-Karna J, Radziwon P, Lipska A. Platelet count, mean platelet volume and thrombocytopoietic indices in healthy women and men. Thromb Res. 2006;118(2):199\u2013204. https:\/\/doi.org\/10.1016\/j.thromres.2005.06.021<\/a>.<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Ittermann T, Fei MA, Petersmann A, Radke D, Greinacher A, V\u00f6lzke H, Thiele T. Mean platelet volume is more important than age for defining reference intervals of platelet counts. PLoS ONE. 2019;14(3):e0213658. https:\/\/doi.org\/10.1371\/journal.pone.0213658<\/a>.<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Jia P, Wang L, Meltzer HY, Zhao Z. Common variants conferring risk of schizophrenia: a pathway analysis of GWAS data. Schizophr Res. 2010;122:38\u201342. https:\/\/doi.org\/10.1016\/j.schres.2010.07.001<\/a>.<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

International Schizophrenia Consortium, Purcell SM, Wray NR, Stone JL, Visscher PM, O\u2019Donovan MC, Sullivan PF, Sklar P. Common polygenic variation contributes to risk of schizophrenia and bipolar disorder. Nature. 2009;460(7256):748\u201352. https:\/\/doi.org\/10.1038\/nature08185<\/a>.<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

\u00d6zdin S, Sarisoy G, B\u00f6ke \u00d6. A comparison of the neutrophil-lymphocyte, platelet-lymphocyte and monocyte-lymphocyte ratios in schizophrenia and bipolar disorder patients – a retrospective file review. Nord J Psychiatry. 2017;71(7):509\u201312. https:\/\/doi.org\/10.1080\/08039488.2017.1340517<\/a>.<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Garc\u00eda-Bueno B, Gass\u00f3 P, MacDowell KS, Callado LF, Mas S, Bernardo M, Lafuente A, Meana JJ, Leza JC. Evidence of activation of the Toll-like receptor-4 Proinflammatory pathway in patients with schizophrenia. J Psychiat Neurosci. 2016;41(3):E46\u201355. https:\/\/doi.org\/10.1503\/jpn.150195<\/a>.<\/p>\n

Article<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Koz\u0142owska E, Agier J, Wysoki\u0144ski A, \u0141ucka A, Sobierajska K, Brzezi\u0144ska-B\u0142aszczyk E. The expression of toll-like receptors in peripheral blood mononuclear cells is altered in schizophrenia. Psychiatry Res. 2019;272:540\u201350. https:\/\/doi.org\/10.1016\/j.psychres.2018.12.138<\/a>.<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Steri M, Idda ML, Whalen MB, Orr\u00f9 V. Genetic variants in mRNA untranslated regions. Wiley Interdiscip Rev RNA. 2018;9(4):e1474. https:\/\/doi.org\/10.1002\/wrna.1474<\/a>.<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Kent WJ, Sugnet CW, Furey TS, Roskin KM, Pringle TH, Zahler AM, Haussler D. The human genome browser at UCSC. Genome Res. 2002;12(6):996\u20131006. https:\/\/doi.org\/10.1101\/gr.229102<\/a>.<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Orhan F, Schwieler L, Fatouros-Bergman H, Malmqvist A, Cervenka S, Collste K, Flyckt L, Farde L, Sellgren CM, Piehl F, Karolinska Schizophrenia Project (KaSP) Consortium, Engberg G, Erhardt S. Increased number of monocytes and plasma levels of MCP-1 and YKL-40 in first-episode psychosis. Acta Psychiat Scand. 2018;138(5):432\u201340. https:\/\/doi.org\/10.1111\/acps.12944<\/a>.<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

M\u00fcller N, Wagner JK, Krause D, Weidinger E, Wildenauer A, Obermeier M, Dehning S, Gruber R, Schwarz MJ. Impaired monocyte activation in schizophrenia. Psychiatry Res. 2012;198(3):341\u20136. https:\/\/doi.org\/10.1016\/j.psychres.2011.12.049<\/a>.<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Hanisch UK, Kettenmann H. Microglia: active sensor and versatile effector cells in the normal and pathologic brain. Nat Neurosci. 2007;10(11):1387\u201394. https:\/\/doi.org\/10.1038\/nn1997<\/a>.<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Munn NA. Microglia dysfunction in schizophrenia: an integrative theory. Med Hypotheses. 2000;54(2):198\u2013202. https:\/\/doi.org\/10.1054\/mehy.1999.0018<\/a>.<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Monji A, Kato T, Kanba S. Cytokines and schizophrenia: Microglia hypothesis of schizophrenia. Psychiatry Clin Neurosci. 2009;63(3):257\u201365. https:\/\/doi.org\/10.1111\/j.1440-1819.2009.01945.x<\/a>.<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Goldsmith DR, Rapaport MH, Miller BJ. A meta-analysis of blood cytokine network alterations in psychiatric patients: comparisons between schizophrenia, bipolar disorder and depression. Mol Psychiatry. 2016;21(12):1696\u2013709. https:\/\/doi.org\/10.1038\/mp.2016.3<\/a>.<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Fond G, Lan\u00e7on C, Korchia T, Auquier P, Boyer L. The role of inflammation in the treatment of schizophrenia. Front Psychiatry. 2020;11:160. https:\/\/doi.org\/10.3389\/fpsyt.2020.00160<\/a>.<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Mostaid MS, Pantelis C, Everall IP, Bousman CA. Decreased peripheral TNF alpha (TNF-\u03b1) mRNA expression in patients with treatment-resistant schizophrenia. Schizophr Res. 2018;202:387\u20138. https:\/\/doi.org\/10.1016\/j.schres.2018.04.032<\/a>.<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Zhu S, Zhao L, Fan Y, Lv Q, Wu K, Lang X, Li Z, Yi Z, Geng D. Interaction between TNF-\u03b1 and oxidative stress status in first-episode drug-na\u00efve schizophrenia. Psychoneuroendocrinology. 2020;114:104595. https:\/\/doi.org\/10.1016\/j.psyneuen.2020.104595<\/a>.<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Peng S, Liang C, Deng S, Fu Y. Study on the clinical correlation between the expression of serum TNF-\u03b1 and iNOS as well as cognitive impairment and disease burden in patients with schizophrenia. Pak J Med Sci. 2022;38(7):1838\u201343. https:\/\/doi.org\/10.12669\/pjms.38.7.5326<\/a>.<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Pierdomenico M, Palone F, Cesi V, Vitali R, Mancuso AB, Cucchiara S, Oliva S, Aloi M, Stronati L. Transcription factor ZNF281: A novel player in intestinal inflammation and fibrosis. Front Immunol. 2018;9:2907. https:\/\/doi.org\/10.3389\/fimmu.2018.02907<\/a>.<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Pieraccioli M, Nicolai S, Pitolli C, Agostini M, Antonov A, Malewicz M, Knight RA, Raschell\u00e0 G, Melino G. ZNF281 inhibits neuronal differentiation and is a prognostic marker for neuroblastoma. Proc Natl Acad Sci U S A. 2018;115(28):7356\u201361. https:\/\/doi.org\/10.1073\/pnas.1801435115<\/a>.<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Zhen J, Ke Y, Pan J, Zhou M, Zeng H, Song G, Yu Z, Fu B, Liu Y, Huang D, Wu H. ZNF320 is a hypomethylated prognostic biomarker involved in immune infiltration of hepatocellular carcinoma and associated with cell cycle. Aging. 2022;14(20):8411\u201336. https:\/\/doi.org\/10.18632\/aging.20435<\/a>.<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Chu T, Hu S, Qi J, Li X, Zhang X, Tang Y, Yang M, Xu Y, Ruan CG, Han Y, Wu DP. Bifunctional effect of the inflammatory cytokine tumor necrosis factor \u03b1 on megakaryopoiesis and platelet production. J Thromb Haemost. 2022;20(12):2998\u20133010. https:\/\/doi.org\/10.1111\/jth.15891<\/a>.<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Srinivas L, Vellichirammal NN, Alex AM, Nair C, Nair IV, Banerjee M. Pro-inflammatory cytokines and their epistatic interactions in genetic susceptibility to schizophrenia. J Neuroinflammation. 2016;13(1):105. https:\/\/doi.org\/10.1186\/s12974-016-0<\/a>.<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n","protected":false},"excerpt":{"rendered":"Jablensky A. Schizophrenia in DSM-5: assets and liabilities. Schizophr Res. 2013;150(1):36\u20137. https:\/\/doi.org\/10.1016\/j.schres.2013.07.037. Article\u00a0 PubMed\u00a0 Google Scholar\u00a0 Ermakov EA,…\n","protected":false},"author":2,"featured_media":85589,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[25],"tags":[43098,916,43097,8921,43096,43095,20494,20495,7129,90,56,54,55],"class_list":{"0":"post-85588","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-genetics","8":"tag-association-study","9":"tag-genetics","10":"tag-immune","11":"tag-inflammation","12":"tag-n-tlr2n","13":"tag-n-tnfn","14":"tag-psychiatry","15":"tag-psychotherapy","16":"tag-schizophrenia","17":"tag-science","18":"tag-uk","19":"tag-united-kingdom","20":"tag-unitedkingdom"},"_links":{"self":[{"href":"https:\/\/www.newsbeep.com\/uk\/wp-json\/wp\/v2\/posts\/85588","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.newsbeep.com\/uk\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.newsbeep.com\/uk\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/uk\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/uk\/wp-json\/wp\/v2\/comments?post=85588"}],"version-history":[{"count":0,"href":"https:\/\/www.newsbeep.com\/uk\/wp-json\/wp\/v2\/posts\/85588\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/uk\/wp-json\/wp\/v2\/media\/85589"}],"wp:attachment":[{"href":"https:\/\/www.newsbeep.com\/uk\/wp-json\/wp\/v2\/media?parent=85588"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.newsbeep.com\/uk\/wp-json\/wp\/v2\/categories?post=85588"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.newsbeep.com\/uk\/wp-json\/wp\/v2\/tags?post=85588"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}