Dec 18, 2021; New Orleans, LA, USA; Detailed view of the 50 yard line before the game between the Louisiana-Lafayette Ragin Cajuns and the Marshall Thundering Herd at the 2021 New Orleans Bowl at Caesars Superdome.

The San Diego State Aztecs (5-1) take on a fellow MWC opponent when they visit the Fresno State Bulldogs (5-2) on Saturday, October 25, 2025 at Valley Children’s Stadium. To find out who we pick to win this matchup, review the rest of this column.

In their most recent game, the Aztecs took down the Nevada Wolf Pack 44-10. Their last time out, the Bulldogs lost 49-21 to the Colorado State Rams.

Jayden Denegal threw for 205 yards, with two touchdowns and no interceptions on 14-of-17 passing (82.4%) for the Aztecs in that matchup against the Wolf Pack. He also added four carries for 41 yards. Lucky Sutton rushed for 76 yards on 16 carries (4.8 yards per carry) and one touchdown. Jordan Napier led the receiving charge against the Wolf Pack, catching five passes for 110 yards.

E.J. Warner went 28-for-49 with 350 yards, three touchdowns and three interceptions for the Bulldogs against the Rams. In that matchup, Brandon Ramirez had a seven-carry, 41-yard game (5.9 yards per attempt). Josiah Freeman collected seven catches for 89 yards (on 15 targets), with two touchdowns.

The Aztecs are the favorites (-3.5) in their matchup against the Bulldogs, with the over/under being 48.5 points. (On the moneyline, the Aztecs are -163 and the Bulldogs are +138.)

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San Diego State vs. Fresno State betting odds and lines

College football odds courtesy of BetMGM Sportsbook. Odds updated Tuesday at 6:03 a.m. ET. For a full list of sports betting odds, access USA TODAY Sports Betting Scores Odds Hub.

Spread favorite: San Diego State (-3.5)Moneyline: San Diego State (-163), Fresno State (+138)Total: 48.5 pointsSan Diego State vs. Fresno State predictionPick ATS: San Diego State (-3.5)Pick OU: Under (48.5)Prediction: San Diego State 28, Fresno State 19San Diego State betting splitsSan Diego State has covered the spread five times in six games.San Diego State is unbeaten ATS (3-0) as a 3.5-point favorite or greater this season.This season, three of San Diego State’s six games have hit the over.Fresno State betting splitsFresno State’s record against the spread in 2025 is 3-4-0.Fresno State has no wins ATS (0-1) as a 3.5-point underdog or more this season.Fresno State has played seven games this season, and four of them have gone over the total.San Diego State vs. Fresno State matchup info, time and how to watchGame date: Saturday, October 25, 2025Game time: 3:30 p.m. ETLocation: Fresno, CaliforniaVenue: Valley Children’s StadiumTV channel: Fox Sports 1Live stream: Watch on Fubo! (Regional restrictions may apply)Live stream: Watch on Sling!Watch San Diego State vs. Fresno State on Fubo! (Regional restrictions may apply)

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