Upstream Bio Reports Positive Top-line Results from the Phase 2 VALIANT Trial of Verekitug for … | News

– Verekitug provided statistically significant and clinically meaningful reductions in annualized asthma exacerbation rate (AAER) with 100 mg q12 and 400 mg q24 week dosing –

– Verekitug also delivered clinically meaningful improvements in lung function (FEV1) and exhaled nitric oxide (FeNO) with both dose regimens –

kAmk6>m–k^6>mk6>m’6C6<:EF8 H2D 86?6C2==J H6== E@=6C2E65[ H:E9 2 D276EJ AC@7:=6 4@?D:DE6?E H:E9 AC:@C DEF5:6Dk^6>mk6>m–k^6>mk^Am

kAmk6>m–k^6>mk6>m~G6C h_T @7 6=:8:3=6 A2E:6?ED 92G6 C@==65 @G6C E@ E96 !92D6 a ‘p{~ =@?8\E6C> 6IE6?D:@? DEF5Jk^6>mk6>m–k^6>mk^Am

kAmk6>m– &ADEC62> q:@ E@ 25G2?46 G6C6<:EF8 :?E@ !92D6 b EC:2=D 😕 D6G6C6 2DE9>2 2?5 r#$H}! 7@==@H:?8 A=2??65 C68F=2E@CJ :?E6C24E:@?D –k^6>mk^Am

kAmk6>m– |2?286>6?E H:== 9@DE 2 =:G6 H6342DE E@52J 2E gi__ 2]>] t% –k^Am

kAmk^6>mk^Am

kAm(p{%wp|[ |2DD][ u63] “[ a_ae Wv{~qt }t($(x#tX \\ k2 9C67lQ9EEADi^^HHH]8=@36?6HDH:C6]4@>^%C24<6Cn52E2l:BKhvx}|?z}G)&H&IqJ+={>DH6″%Bd*#qAubuqF$hyzx9(a_ez6Fa7>xdA=(#E*b>’4}+GIh!swI+==<}Ggx&(duD6~=8K38q#cq7*:<$dglQ C6=lQ?@7@==@HQm&ADEC62> q:@[ x?4]k^2m W}2D52Bi &!qX[ 2 4=:?:42=\DE286 4@>A2?J 56G6=@A:?8 EC62E>6?ED 7@C :?7=2>>2E@CJ 5:D62D6D[ H:E9 2? :?:E:2= 7@4FD @? D6G6C6 C6DA:C2E@CJ 5:D@C56CD[ E@52J 2??@F?465 A@D:E:G6 E@A\=:?6 C6DF=ED 7C@> E96 !92D6 a ‘p{xp}% 4=:?:42= EC:2= 6G2=F2E:?8 E96 D276EJ 2?5 677:424J @7 G6C6<:EF8 😕 25F=ED H:E9 D6G6C6 2DE9>2] ‘6C6<:EF8 😀 E96 @?=J @H? 4=:?:42=\DE286 2?E28@?:DE E2C86E:?8 E96 C646AE@C 7@C E9J>:4 DEC@>2= =J>A9@A@:6E:? W%${!X]k^Am

kAm’p{xp}% >6E E96 DEF5J’D AC:>2CJ 6?5A@:?E @7 2 DE2E:DE:42==J D:8?:7:42?E 2?5 4=:?:42==J >62?:?87F= C65F4E:@? 😕 E96 2??F2=:K65 2DE9>2 6I246C32E:@? C2E6 Wppt#X H:E9 3@E9 6G6CJ `a H66< WB`aHX 2?5 6G6CJ ac H66< WBacHX 5@D:?8[ H:E9 G6C6<:EF8 56>@?DEC2E:?8 2 C65F4E:@? 😕 ppt# @7 deT WAU=Ej_]___bX H96? 5@D65 2E `__ >8 B`aH 2?5 bhT WAU=Ej_]_aX H96? 5@D65 2E c__ >8 BacH[ 2D 4@>A2C65 H:E9 A=2463@]k^Am

kAm!=2463@\25;FDE65 :>AC@G6>6?E 😕 =F?8 7F?4E:@?[ 2D >62DFC65 3J E96 7@C465 6IA:C2E@CJ G@=F>6 😕 @?6 D64@?5 Wut’`X[ H2D `aa >{ 2E H66< e_ H:E9 G6C6<:EF8 `__ >8 B`aH[ 2?5 `bh >{ 2E H66< e_ H:E9 c__ >8 BacH] pE H66< e_[ G6C6<:EF8 2=D@ DFAAC6DD65 6I92=65 ?:EC:4 @I:56 Wu6}~X 4@>A2C65 E@ A=2463@ 3J a_]c AA3 WAU=Ej_]___bX H96? 5@D65 2E `__ >8 B`aH[ 2?5 3J ae]b AA3 WAU=Ej_]___`X H96? 5@D65 2E c__ >8 BacH] %96D6 52E2 C6AC6D6?E65 2 >62? cb]dT WAl_]_bX C65F4E:@? 7C@> 32D6=:?6 😕 E96 `__ >8 B`aH 8C@FA 2?5 2 >62? cc]hT WAl_]_bX C65F4E:@? 7C@> 32D6=:?6 😕 E96 c__ >8 BacH 8C@FA] p E9:C5 =@H\5@D6 EC62E>6?E 8C@FA[ `__ >8 BacH[ 56>@?DEC2E65 2 DE2E:DE:42==J D:8?:7:42?E 67764E @? ppt#[ 3FE 5:5 ?@E AC@G:56 4@?D:DE6?E :>AC@G6>6?ED 😕 @E96C 6?5A@:?ED]k^Am

kAmp55:E:@?2= AC6\DA64:7:65 2?2=JD6D @7 D64@?52CJ @FE4@>6D 2E H66< ac C6G62=65 DE2E:DE:42==J D:8?:7:42?E A=2463@\25;FDE65 :>AC@G6>6?ED 4@>A2C65 E@ 32D6=:?6 😕 3@E9 ut’` 2?5 u6}~ H:E9 E96 `__ >8 B`aH 2?5 c__ >8 BacH 5@D6 C68:>6?D]k^Am

kAm’6C6<:EF8 H2D 86?6C2==J H6== E@=6C2E65 24C@DD 2== 24E:G6 5@D6D[ 56>@?DEC2E:?8 2 72G@C23=6 D276EJ AC@7:=6 4@?D:DE6?E H:E9 AC6G:@FD DEF5:6D]k^Am

kAm“(6 2C6 6I4:E65 E@ D92C6 E96D6 C@3FDE 52E2 7C@> ‘p{xp}%[ H9:49 :?5:42E6 E96 A@E6?E:2= @7 G6C6<:EF8’D >62?:?87F= 4=:?:42= 67764E 😕 D6G6C6 2DE9>2 2?5 AC@G:56 2 DEC@?8 7@F?52E:@? 2D H6 25G2?46 G6C6<:EF8 :?E@ !92D6 b 4=:?:42= EC:2=D 2D BF:4<=J 2D A@DD:3=6[” D2:5 p2C@? s6J<:?[ |s[ r9:67 |65:42= ~77:46C 2?5 w625 @7 #6D62C49 U2>Aj s6G6=@A>6?E 2E &ADEC62> q:@] “(6 2C6 566A=J 8C2E67F= E@ E96 A2E:6?ED[ :?G6DE:82E@CD[ 2?5 DEF5J E62>D H9@D6 A2CE:4:A2E:@? >256 E9:D AC@8C6DD A@DD:3=6] (:E9 E96 4@>A=6E:@? @7 @FC ‘p{xp}% EC:2=[ 9F?5C65D @7 A2E:6?ED 92G6 ?@H 366? 5@D65 H:E9 G6C6<:EF8 24C@DD @FC 4=:?:42= AC@8C2>D[ AC@G:5:?8 2 8C@H:?8 3@5J @7 4=:?:42= 6IA6C:6?46 E92E C6:?7@C46D @FC 4@?7:56?46 😕 :ED A@E6?E:2= 2?5 :ED 5:776C6?E:2E65 AC@5F4E AC@7:=6] %@86E96C H:E9 E96 A@D:E:G6 C6DF=ED 7C@> @FC ‘xq#p}% EC:2= 😕 r#$H}![ H6 ?@H 92G6 2? @AA@CEF?:EJ E@ :?4@CA@C2E6 3@E9 DEC@?8 4=:?:42= 52E2 D6ED H:E9 2? :?\56AE9 2?2=JD:D @7 E96 288C682E6 A92C>24@=@8J 7:?5:?8D E@ 8F:56 52E2\5C:G6? 564:D:@?D 23@FE 5@D6 D6=64E:@? 2?5 EC:2= 56D:8? 7@C !92D6 b]”k^Am

kAm“%96D6 4@>A6==:?8 7:?5:?8D 7C@> ‘p{xp}% DEC6?8E96? G6C6<:EF8’D A@E6?E:2= E@ 25G2?46 E96 DE2?52C5 @7 42C6 H:E9 2 9:89=J 4@>A6E:E:G6 677:424J AC@7:=6 2?5 =6DD 7C6BF6?E 5@D:?8—2? :>A@CE2?E 4@>3:?2E:@? 7@C A6@A=6 =:G:?8 H:E9 D6G6C6 2DE9>2[” DE2E65 #2?5 $FE96C=2?5[ |s[ r9:67 tI64FE:G6 ~77:46C @7 &ADEC62> q:@] “(6 :?E6?5 E@ C2A:5=J 25G2?46 G6C6<:EF8 :?E@ !92D6 b EC:2=D 😕 D6G6C6 2DE9>2 2?5 r#$H}!] x? A2C2==6=[ H6 2=D@ 4@?E:?F6 E@ AC@8C6DD G6C6<:EF8 😕 @FC @?8@:?8 !92D6 a ‘t}%t EC:2= 😕 A2E:6?ED H:E9 r~!s[ H96C6 H6 92G6 6?C@==65 >@C6 E92? e_T @7 A2E:6?ED E@ 52E6] pD H6 EC2?D:E:@? :?E@ 2 =2E6 4=:?:42=\DE286 4@>A2?J AFCDF:?8 DF3DE2?E:2= >2C<6E @AA@CEF?:E:6D[ @FC 7@4FD C6>2:?D @? 5:D4:A=:?65 6I64FE:@? 2?5 6IA2?5:?8 &ADEC62> q:@’D 42A23:=:E:6D E@ DFAA@CE =@?8\E6C> 8C@HE9]”k^Am

kAm’p{xp}% W}r%_e`hegfhX 😀 2 !92D6 a 8=@32=[ C2?5@>:K65[ 5@F3=6\3=:?5[ A=2463@\4@?EC@==65[ 5@D6\C2?8:?8[ A2C2==6= 8C@FA 4=:?:42= EC:2= E92E 6G2=F2E65 E96 D276EJ 2?5 677:424J @7 G6C6<:EF8 7@C FA E@ e_ H66:?:>F> @7 ac H666?E[ 😕 cfg A2E:6?ED H:E9 D6G6C6 2DE9>2]k^Am

kAmt=:8:3=6 A2CE:4:A2?ED H9@ 4@>A=6E65 E96 !92D6 a ‘p{xp}% 4=:?:42= EC:2= H6C6 @776C65 6?C@==>6?E 😕 ‘p{~ W}r%_eheecfhX[ 2 =@?8\E6C> 6IE6?D:@? W{%tX DEF5J 56D:8?65 E@ 6G2=F2E6 E96 =@?8\E6C> D276EJ 2?5 677:424J @7 G6C6<:EF8] rFCC6?E EC2?D:E:@? C2E6D :?5:42E6 >@C6 E92? h_T @7 6=:8:3=6 A2E:6?ED 92G6 C@==65 @G6C E@ E96 !92D6 a ‘p{~ {%t DEF5J]k^Am

kAm“$6G6C6 2DE9>2[ H96? F?23=6 E@ 36 4@?EC@==65 3J DE2?52C5 @7 42C6 >62DFC6D[ 42? D:8?:7:42?E=J 2?5 49C@?:42==J 5:DCFAE A2E:6?ED’ BF2=:EJ @7 =:76[ 2?5 AFE E96> 2E C:D< 7@C A@E6?E:2==J =:76\E9C62E6?:?8 6I246C32E:@? 6G6?ED E92E 42? =625 E@ 6>6C86?4J C@@>D G:D:ED 2?5 9@DA:E2=:K2E:@?D[” D2:5 |:4926= (649D=6C[ |s[ ||$4[ !C@76DD@C @7 |65:4:?6[ s:C64E@C @7 }2E:@?2= y6H:D9 r@96? u2>:=J pDE9>2 x?DE:EFE6] “%96D6 52E2 DF886DE E92E G6C6<:EF8 42? A@E6?E:2==J @776C A2E:6?ED >62?:?87F= :>AC@G6>6?ED 😕 E96:C 3C62E9:?8 2?5 2DE9>2 DJ>AE@>D H:E9 =6DD 7C6BF6?E 5@D:?8 E92? E96 4FCC6?E=J 2G2:=23=6 3:@=@8:4D[ 2?5 x 36=:6G6 E92E G6C6<:EF8 4@F=5 C6AC6D6?E 2? :>A@CE2?E 25G2?46>6?E 7@C :?5:G:5F2=D =:G:?8 H:E9 D6G6C6 2DE9>2]”k^Am

kAm&ADEC62> q:@ 56D:8?65 E96 ‘p{xp}% EC:2= FD:?8 6?5A@:?ED E92E[ A6?5:?8 :?E6C24E:@?D H:E9 C68F=2E@CJ 2FE9@C:E:6D[ 4@F=5 AC@5F46 52E2 E@ DFAA@CE DF3>:DD:@?D 7@C AC@5F4E 2AAC@G2=] !=2??:?8 24E:G:E:6D 7@C !92D6 b EC:2=D 😕 D6G6C6 2DE9>2 2?5 r#$H}! 92G6 4@>>6?465[ 2?5 E96 r@>A2?J :?E6?5D E@ :?:E:2E6 C68:DEC2E:@?2= EC:2=D 😕 3@E9 :?5:42E:@?D 7@==@H:?8 A=2??65 C68F=2E@CJ :?E6C24E:@?D]k^Am

kAmp55:E:@?2= 56E2:=D 7C@> E96 ‘p{xp}% EC:2= H:== 36 AC6D6?E65 2E 2 7FEFC6 >65:42= 4@?76C6?46]k^Am

kAm(6342DE s6E2:=Dk^Am

kAm&ADEC62> q:@’D H6342DE E@ 5:D4FDD E96 E@A\=:?6 C6DF=ED 7C@> E96 !92D6 a ‘p{xp}% EC:2= H:== 368:? E@52J 2E gi__ 2]>] t%] %96 =:G6 H6342DE 42? 36 2446DD65 G:2 E9:D k2 9C67lQ9EEADi^^HHH]8=@36?6HDH:C6]4@>^%C24<6Cn52E2l=3)p4xdd5Er’=>*eGqsd#c?’Fq)s*>>>w6IKFvs#e3#A$JftA4t9xJz$;G$’4g)(A#(@?#+)<`5’p*”lQ C6=lQ?@7@==@HQm=:?A2?J’D H63D:E6 2E k2 9C67lQ9EEADi^^HHH]8=@36?6HDH:C6]4@>^%C24<6Cn52E2lf\%6tdw!!wJ@fu7fyCKr”)8″G#r9tK26h};`bv>dz’=E@e’@g$v$:8D8vAC(c}E{Hr~_Gr6Hyw=aFJ?=;|+~2H_fJf9t!84{?s()”d>KBC{\dt2avGFc}z{:>|E(By:?hez$c}H4#As”=E4hGh+b64e`zGI3I$G%Q C6=lQ?@7@==@HQm9EEADi^^:?G6DE@CD]FADEC62>3:@]4@>^?6HD\6G6?ED^6G6?ED]k^2m p C6A=2J @7 E96 H6342DE H:== 36 2G2:=23=6 @? E96 H63D:E6 7@==@H:?8 E96 42==]k^Am

kAmp3@FE $6G6C6 pDE9>2k^Am

kAm$6G6C6 2DE9>2 😀 2 4@>A=6I[ 49C@?:4 :?7=2>>2E@CJ 5:D62D6 @7 E96 2:CH2JD 492C24E6C:K65 3J A6CD:DE6?E DJ>AE@>D[ C64FCC6?E 6I246C32E:@?D[ 2?5 :>A2:C65 BF2=:EJ @7 =:76 56DA:E6 EC62E>6?E H:E9 9:89\5@D6 4@CE:4@DE6C@:5D 2?5 @E96C =@?8\24E:?8 >65:42E:@? E92E 244@F?ED 7@C 2 5:DAC@A@CE:@?2E6 D92C6 @7 2DE9>2\C6=2E65 4@DED 2?5 962=E942C6 FE:=:K2E:@?] $6G6C6 2DE9>2 😀 2 96E6C@86?6@FD 5:D62D6 5C:G6? 3J >F=E:A=6 :?7=2>>2E@CJ A2E9H2JD[ :?4=F5:?8 3@E9 %JA6 a 2?5 ?@?\%JA6 a >6492?:D>D]k^Am

kAmpDE9>2 27764ED 2AAC@I:>2E6=J bd_ >:==:@? A6@A=6 H@C=5H:56[ H:E9 7:G6 E@ `_ A6C46?E DF776C:?8 7C@> D6G6C6 2DE9>2] rFCC6?E=J[ E96C6 2C6 2AAC@I:>2E6=J `]b >:==:@? 3:@=@8:4\6=:8:3=6 D6G6C6 2DE9>2 A2E:6?ED 😕 E96 &$[ E9@F89 E96 FD6 @7 3:@=@8:4 E96C2A:6D C6>2:?D =:>:E65 C6=2E:G6 E@ E96 D:K6 @7 E96 6=:8:3=6 A@AF=2E:@?] (6 36=:6G6 ?6H EC62E>6?E @AE:@?D 7@C D6G6C6 2DE9>2 2C6 ?66565 E@ 7FCE96C :>AC@G6 4@?EC@= @7 6I246C32E:@?D 2?5 DJ>AE@>D[ 2?5 C65F46 E96 EC62E>6?E 3FC56?[ DF49 2D E96 ?665 7@C 7C6BF6?E :?;64E:@?D]k^Am

kAmp3@FE E96 !92D6 a ‘p{xp}% %C:2=k^Am

kAm%96 !92D6 a ‘p{xp}% EC:2= W}r%_e`hegfhX 😀 2 8=@32=[ C2?5@>:K65[ A=2463@\4@?EC@==65[ 5@D6\7:?5:?8[ A2C2==6= 8C@FA 4=:?:42= EC:2=[ 56D:8?65 E@ 2DD6DD E96 677:424J 2?5 D276EJ @7 G6C6<:EF8 😕 25F=ED H:E9 D6G6C6 2DE9>2] !2CE:4:A2?ED H6C6 C2?5@>:K65 :?E@ @?6 @7 7@FC 8C@FAD[ C646:G:?8 6:E96C `__ >8 @7 G6C6<:EF8 6G6CJ ac H668 @7 G6C6<:EF8 6G6CJ ac H668 @7 G6C6<:EF8 6G6CJ `a H66:?:DE6C65 DF34FE2?6@FD=J] %96 DEF5J 6G2=F2E65 G6C6<:EF8’D 677:424J 😕 E96 EC62E>6?E @7 D6G6C6 2DE9>2 5FC:?8 2 EC62E>6?E A6C:@5 FA E@ e_ H66:?:>F> @7 ac H662CJ 6?5A@:?E @7 C65F4E:@? @7 E96 2??F2=:K65 2DE9>2 6I246C32E:@? C2E6 Wppt#X] $64@?52CJ 6?5A@:?ED :?4=F565 492?86D 😕 2:C 6I92=2E:@?[ ?:EC:4 @I:56 6I92=2E:@?[ 2?5 2 A2E:6?E\C6A@CE65 2DD6DD>6?E @7 2DE9>2 4@?EC@=[ E9@F89 E96D6 H6C6 ?@E 56D:8?65 H:E9 DF77:4:6?E A@H6C E@ 56E64E DE2E:DE:42==J D:8?:7:42?E 67764ED]k^Am

kAmp3@FE ‘6C6<:EF8k^Am

kAm’6C6<:EF8 😀 2 ?@G6= C64@>3:?2?E 7F==J 9F>2? :>>F?@8=@3F=:? v` Wx8v`X >@?@4=@?2= 2?E:3@5J E92E 3:?5D E@ E96 E9J>:4 DEC@>2= =J>A9@A@:6E:? W%${!X C646AE@C 2?5 :?9:3:ED AC@:?7=2>>2E@CJ D:8?2=:?8 :?:E:2E65 3J %${!] xE 😀 E96 @?=J @H? 2?E28@?:DE 4FCC6?E=J 😕 4=:?:42= 56G6=@A>6?E E92E E2C86ED 2?5 :?9:3:ED E96 %${! C646AE@C]k^Am

kAm%${! 😀 2 4JE@<:?6 E92E 😀 2 <6J 5C:G6C @7 E96 :?7=2>>2E@CJ C6DA@?D6 😕 >2;@C 2==6C8:4 2?5 :?7=2>>2E@CJ 5:D62D6D[ DF49 2D 2DE9>2[ H96C6 5:DCFAE:@? @7 %${! D:8?2=:?8 92D 366? 4=:?:42==J G2=:52E65 2D 2? 67764E:G6 E96C2A6FE:4 DEC2E68J] %${! 24E:G2E:@? 😀 @?6 @7 E96 7:CDE 6G6?ED 😕 E96 :?7=2>>2E@CJ 42D4256 DE:>F=2E65 3J 2==6C86?D[ G:CFD6D 2?5 @E96C EC:886CD[ :?:E:2E:?8 E96 24E:G2E:@? @7 5@H?DEC62> E2C86ED DF49 2D x{\c[ x{\d[ x{\`b[ x{\`f 2?5 x8t] q642FD6 %${! 😀 2 E2C86E FADEC62> 😕 E96 :?7=2>>2E@CJ 42D4256[ 3=@4<:?8 E96 %${! C646AE@C AC6D6?ED 2? @AA@CEF?:EJ 7@C 2 D:?8=6 EC62E>6?E E@ :>A24E E96 5C:G6CD @7 >F=E:A=6 A2E9@=@8:42= :?7=2>>2E@CJ AC@46DD6D 24C@DD 2 3C@25 D6E @7 5:D62D6D]k^Am

kAm’6C6<:EF8 92D 25G2?465 :?E@ E9C66 D6A2C2E6 8=@32=[ A=2463@\4@?EC@==65[ C2?5@>:K65 !92D6 a 4=:?:42= EC:2=D :?4=F5:?8 E96 C646?E=J 4@>A=6E65 A@D:E:G6 ‘xq#p}% EC:2= W}r%_e`ecf_cX 😕 A2E:6?ED H:E9 r#$H}! 2?5 ‘p{xp}% EC:2= W}r%_e`hegfhX 😕 A2E:6?ED H:E9 D6G6C6 2DE9>2] %96 ‘t}%t EC:2= W}r%_ehg`_fgX 😕 A2E:6?ED H:E9 >@56C2E6\E@\D6G6C6 49C@?:4 @3DECF4E:G6 AF=>@?2CJ 5:D62D6 Wr~!sX 😀 @?8@:?8] p55:E:@?2==J[ 😕 |2J a_ad[ &ADEC62> q:@ :?:E:2E65 E96 ‘p{~ EC:2= W}r%_eheecfhX[ 2 =@?8\E6C> 6IE6?D:@? DEF5J 😕 6=:8:3=6 A2CE:4:A2?ED H:E9 D6G6C6 2DE9>2 H9@ 4@>A=6E65 E96 ‘p{xp}% !92D6 a 4=:?:42= EC:2=]k^Am

kAmp3@FE &ADEC62> q:@k^Am

kAm&ADEC62> q:@ 😀 2 4=:?:42=\DE286 3:@E649?@=@8J 4@>A2?J 56G6=@A:?8 EC62E>6?ED 7@C :?7=2>>2E@CJ 5:D62D6D[ H:E9 2? :?:E:2= 7@4FD @? D6G6C6 C6DA:C2E@CJ 5:D@C56CD] %96 r@>A2?J 😀 56G6=@A:?8 G6C6<:EF8[ E96 @?=J @H? 2?E28@?:DE 4FCC6?E=J 😕 4=:?:42= 56G6=@A>6?E E92E E2C86ED E96 C646AE@C 7@C E9J>:4 DEC@>2= =J>A9@A@:6E:? W%${!X[ 2 4JE@<:?6 H9:49 😀 2 4=:?:42==J G2=:52E65 5C:G6C @7 :?7=2>>2E@CJ C6DA@?D6 A@D:E:@?65 FADEC62> @7 >F=E:A=6 D:8?2=:?8 42D4256D E92E 27764E 2 G2C:6EJ @7 :>>F?6 >65:2E65 5:D62D6D] %96 r@>A2?J 92D 25G2?465 E9:D 9:89=J A@E6?E >@?@4=@?2= 2?E:3@5J :?E@ D6A2C2E6 !92D6 a EC:2=D 7@C E96 EC62E>6?E @7 49C@?:4 C9:?@D:?FD:E:D H:E9 ?2D2= A@=JAD Wr#$H}!X[ D6G6C6 2DE9>2[ 2?5 49C@?:4 @3DECF4E:G6 AF=>@?2CJ 5:D62D6 Wr~!sX] &ADEC62> q:@’D E62> 😀 4@>>:EE65 E@ >2I:>:K:?8 G6C6<:EF8’D F?:BF6 2EEC:3FE6D E@ 255C6DD E96 DF3DE2?E:2= F?>6E ?665D 7@C A2E:6?ED F?56CD6CG65 3J E@52J’D DE2?52C5 @7 42C6] %@ =62C? >@C6[ A=62D6 G:D:E  k2 9C67lQ9EEADi^^HHH]8=@36?6HDH:C6]4@>^%C24<6Cn52E2lJcwrf=0a?<3a}r|I0|“|K70\IF!w0;7dz+b?9IEy2}G~H@}a<@7?$rqJFfwp>{t`g;’&(d:e$uyh+x~+@gBH8Jp”p~6qyqay>9#?&Jp|?w&ypf”$BCqb|H5E2gg6@(t!A(!+)0G&<$4+I(;sc’sd%)\0Fyxrz”‘6J0%’|xI!fxKv3(fDbBD%’_d+Gg#’&*EG&=qy*K)}g#*x3{G4s%tq&(z?_:AxE;:Dz=GF@((92K~`2g\BcdG?=q8;D”}(gK%|:z}KB7\?=5)g%%Ksd7?9?KKBp)c>B=zy7`ss=_c+)7Ju)gahAaw`=#>Kp)!<~44\AEud4HD3`#a&d?0@5Iwvf:Kg6gzxveh6s\9t=~f40$dz(}G9|26`;ud_D&F97_+bI?@wgbeeG56K$hd(Jct=fh@c?!+@%dqs}sgEgGg&~E5;D}}++7gsJD’3dBaf’D<4aKDHa)#vc9{hIgA$4rAv9EaJ”A$v%r};E{A=|t7fB<%f#$~=%H4Icfh~H?8A@<_b+)=+)z&0@\9t~E?d~F\p!xcw}*HhD;F;}t~_`3!&%u”GJ|ur}B_’:A@3Bg{|\(!Jt@g%ud+”g?”3wyDvcy)a#A\EF!?qf8)H~?FwHllQ C6=lQ?@7@==@HQmHHH]FADEC62>3:@]4@>k^2m]k^Am

kAmu@CH2C5\{@@<:?8 $E2E6>6?EDk^Am

kAm%9:D AC6DD C6=62D6 4@?E2:?D “7@CH2C5\=@@<:?8 DE2E6>6?ED” H:E9:? E96 >62?:?8 @7 $64E:@? afp @7 E96 $64FC:E:6D p4E @7 `hbb 2?5 $64E:@? a`t @7 E96 $64FC:E:6D tI492?86 p4E @7 `hbc[ 6249 2D 2>6?565] %96D6 DE2E6>6?ED >2J 36 :56?E:7:65 3J H@C5D DF49 2D “2:>D[” “2?E:4:A2E6D[” “36=:6G6D[” “4@?E:?F6[” “4@F=5[” “6DE:>2E6D[” “6IA64ED[” “7@C642DED[” “8@2=[” “:?E6?5D[” “>2J[” “A=2?D[” “A@DD:3=6[” “A@E6?E:2=[” “AC65:4E[” “AC@;64E[” “D66:=2C 6IAC6DD:@?D] p?J DE2E6>6?ED 😕 E9:D AC6DD C6=62D6 E92E 2C6 ?@E DE2E6>6?ED @7 9:DE@C:42= 724E >2J 36 566>65 E@ 36 7@CH2C5\=@@<:?8 DE2E6>6?ED] %96D6 7@CH2C5\=@@<:?8 DE2E6>6?ED :?4=F56[ H:E9@FE =:>:E2E:@?[ 6IAC6DD @C :>A=:65 DE2E6>6?ED C682C5:?8i E96 4=:?:42= 56G6=@A>6?E @7 G6C6<:EF8 7@C E96 EC62E>6?E @7 D6G6C6 2DE9>2[ r#$H}! 2?5 r~!s[ :?4=F5:?8 E96 E:>:?8[ AC@8C6DD 2?5 C6DF=ED @7 @?8@:?8 2?5 A=2??65 4=:?:42= EC:2=Dj 6IA64E2E:@?D 7@C 7FEFC6 5:D4FDD:@?D H:E9 C68F=2E@CJ 2FE9@C:E:6D 2?5 E96 A@E6?E:2= @7 E96 6?5A@:?ED @7 E96 r@>A2?J’D 4=:?:42= EC:2=D E@ AC@5F46 52E2 E92E 4@F=5 DFAA@CE DF3>:DD:@?D 7@C AC@5F4E 2AAC@G2=j 6IA64E2E:@?D C682C5:?8 E96 5:776C6?E:2E:@?[ D276EJ[ 677:424J[ E@=6C23:=:EJ[ @C 6IE6?565 5@D:?8 :?E6CG2= @7 G6C6<:EF8j 6IA64E2E:@?D 7@C E96 D:K6 2?5 8C@HE9 A@E6?E:2= @7 E96 >2C<6E 7@C G6C6<:EF8 2?5 E96 r@>A2?J’D 23:=:EJ E@ D6CG6 E92E >2C<6Ej 46CE2:? 24E:G:E:6D 2?5 ?6IE DE6AD E@ DFAA@CE E96 r@>A2?J’D >2EFC2E:@? :?E@ 2 =2E6 4=:?:42=\DE286 4@>A2?Jj 2?5 A2CE:4:A2E:@? 2E FA4@>:?8 :?G6DE@C 4@?76C6?46D 2?5 >65:42= 4@?8C6DD6D] p?J 7@CH2C5\=@@<:?8 DE2E6>6?ED 😕 E9:D AC6DD C6=62D6 2C6 32D65 @? E96 r@>A2?J’D 4FCC6?E 6IA64E2E:@?D[ 6DE:>2E6D 2?5 AC@;64E:@?D @?=J 2D @7 E96 52E6 @7 E9:D C6=62D6 2?5 2C6 DF3;64E E@ 2 ?F>36C @7 C:D2E6C:2==J 2?5 25G6CD6=J 7C@> E9@D6 D6E 7@CE9 😕 @C :>A=:65 3J DF49 7@CH2C5\=@@<:?8 DE2E6>6?ED] #6256CD 2C6 42FE:@?65 E92E 24EF2= C6DF=ED[ =6G6=D @7 24E:G:EJ[ D276EJ[ 677:424J[ A6C7@C>2?46 @C 6G6?ED 2?5 4:C4F>DE2?46D 4@F=5 5:776C >2E6C:2==J 7C@> E9@D6 6IAC6DD65 @C :>A=:65 😕 E96 r@>A2?J’D 7@CH2C5\=@@<:?8 DE2E6>6?ED 5F6 E@ 2 G2C:6EJ @7 C:D:E2E:@?[ C:D q:@’D 23:=:EJ E@ 25G2?46 G6C6<:EF8 E9C@F89 4=:?:42= 56G6=@A>6?E[ 2?5 E@ @3E2:? C68F=2E@CJ 2AAC@G2= @7 2?5 F=E:>2E6=J 4@>>6C4:2=:K6 G6C6<:EF8 @? E96 6IA64E65 E:>6=:?6[ :7 2E 2==j E96 C6DF=ED @7 AC64=:?:42= DEF5:6D[ @C 4=:?:42= DEF5:6D ?@E 36:?8 AC65:4E:G6 @7 7FEFC6 C6DF=ED 😕 4@??64E:@? H:E9 7FEFC6 DEF5:6Dj E96 :?:E:2E:@?[ E:>:?8[ AC@8C6DD 2?5 C6DF=ED @7 4=:?:42= EC:2=Dj &ADEC62> q:@’D 23:=:EJ E@ 7F?5 :ED 56G6=@A>6?E 24E:G:E:6D 2?5 249:6G6 56G6=@A>6?E 8@2=Dj &ADEC62> q:@’D 56A6?56?46 @? E9:C5 A2CE:6D E@ 4@?5F4E 4=:?:42= EC:2=D 2?5 >2?F724EFC6 G6C6<:EF8[ 2?5 4@>>6C4:2=:K6 G6C6<:EF8[ :7 2AAC@G65j &ADEC62> q:@’D 23:=:EJ E@ 2EEC24E[ 9:C6 2?5 C6E2:? <6J A6CD@??6=[ 2?5 AC@E64E :ED :?E6==64EF2= AC@A6CEJj &ADEC62> q:@’D 7:?2?4:2= 4@?5:E:@? 2?5 ?665 7@C DF3DE2?E:2= 255:E:@?2= 7F?5D 😕 @C56C E@ 4@>A=6E6 56G6=@A>6?E 24E:G:E:6D 2?5 4@>>6C4:2=:K6 G6C6<:EF8[ :7 2AAC@G65j C68F=2E@CJ 56G6=@A>6?ED 2?5 2AAC@G2= AC@46DD6D @7 E96 &]$] u@@5 2?5 sCF8 p5>:?:DEC2E:@? 2?5 4@>A2C23=6 7@C6:8? C68F=2E@CJ 2FE9@C:E:6Dj &ADEC62> q:@’D 4@>A6E:E@CD 2?5 :?5FDECJj 2?5 @E96C C:D q:@’D >@DE C646?E p??F2= #6A@CE @? u@C> `_\z 2?5 “F2CE6C=J #6A@CE @? u@C> `_\”[ 2D H6== 2D 2?J DF3D6BF6?E 7:=:?8D H:E9 E96 $tr] p?J 7@CH2C5\=@@<:?8 DE2E6>6?ED C6AC6D6?E &ADEC62> q:@’D G:6HD @?=J 2D @7 E@52J 2?5 D9@F=5 ?@E 36 C6=:65 FA@? 2D C6AC6D6?E:?8 :ED G:6HD 2D @7 2?J DF3D6BF6?E 52E6] &ADEC62> q:@ 6IA=:4:E=J 5:D4=2:>D 2?J @3=:82E:@? @C F?56CE2<:?8 E@ FA52E6 2?J 7@CH2C5\=@@<:?8 DE2E6>6?ED 4@?E2:?65 96C6:? E@ C67=64E 2?J 492?86 😕 :ED 6IA64E2E:@?D @C 2?J 492?86D 😕 6G6?ED[ 4@?5:E:@?D @C 4:C4F>DE2?46D @? H9:49 2?J DF49 DE2E6>6?E 😀 32D65 6I46AE E@ E96 6IE6?E C6BF:C65 3J =2H[ 2?5 4=2:>D E96 AC@E64E:@? @7 E96 D276 92C3@C 7@C 7@CH2C5\=@@<:?8 DE2E6>6?ED 4@?E2:?65 😕 E96 !C:G2E6 $64FC:E:6D {:E:82E:@? #67@C> p4E @7 `hhd]k^Am

kAmx?G6DE@C 2?5 |65:2 r@?E24Eik^Am

kAm|6882? qF4

kAms:C64E@C[ r@CA@C2E6 r@>>F?:42E:@?D 2?5 x?G6DE@C #6=2E:@?Dk^Am

kAmk2 9C67lQ>2:=E@i:CoFADEC62>3:@]4@>Qm:CoFADEC62>3:@]4@>k^2mk^Am

kAmk^Am

kAmk^Am

Copyright 2026 GlobeNewswire, Inc.