A man died early Wednesday after a shooting in San Francisco’s South of Market neighborhood, police said.

Officers responded around 1:31 a.m. to the 100 block of Sixth Street after a report of a shooting, authorities said.

At the scene, officers found the victim suffering from gunshot wounds and began rendering aid. Paramedics took the man to a local hospital with life-threatening injuries, but he was later pronounced dead, police said.

Police have not identified the victim and did not say whether anyone has been arrested.

Authorities are actively investigating the case. Anyone with information is asked to call 415-575-4444 or text a tip to TIP411 and begin the message with SFPD.

The killing comes as San Francisco has seen an uptick in homicides this year, according to preliminary police data.

Through Feb. 15, police had investigated six homicides in 2026, compared with one during the same period in 2025; four of this year’s six homicides involved firearms, the data shows. A Feb. 27 killing in Potrero Hill was not included in those totals.

City leaders have made Sixth Street a focal point of public safety efforts.

“Before we started and in the beginning, Sixth Street has looked as bad as it’s ever looked in my lifetime,” San Francisco police Sgt. Kevin Cuadro told the Chronicle during a 2025 patrol of the corridor. “There’s been small wins, but obviously it’s far, far from perfection. … It’s still pretty sad.”

This article originally published at Man shot and killed in San Francisco’s SoMa neighborhood.