49ers at Texans prediction: Odds, expert picks, QB matchup, injury update, betting trends, and stats

Mac Jones continues under center for the 49ers (5-2) when they travel to Houston for a Sunday afternoon tilt against the Texans (2-4).

Despite being one of the most banged-up teams in the NFL, San Francisco sits tied atop the NFC West with the Seahawks and the Rams. A big reason is the play of Jones under center. The veteran has resurrected his career in leading San Francisco forward despite injuries to a laundry list of players including Brock Purdy, Brandon Aiyuk, and Nick Bosa.

The Texans are at an inflection point in their season. After getting waxed by the Seahawks last week, Houston now trails Indianapolis by three games in the AFC South. Maybe because this week is a home game, but it feels like this is close to a must-win situation for DeMeco Ryans and co. The good news for Houston is the Texans boast the NFL’s top-ranked defense in points allowed per game.

Last week, the 49ers knocked off the Atlanta Falcons, 20-10. The Texans lost at Seattle, 27-19.

Lets take a deeper dive into this week’s matchup between the 49ers and the Texans.

NBC Sports has all the latest info and analysis you need, including how to tune in for kickoff, odds from DraftKings, player news and updates, and of course our predictions and best bets for the game from our staff of experts.

Game Details and How to watch the 49ers at the Texans live SundayDate: Sunday, October 26, 2025Time: 1:00PM ESTSite: NRG StadiumCity: Houston, TXNetwork/Streaming: FOX

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Game odds for the 49ers at the Texans

The latest odds as of Friday courtesy of DraftKings:

Moneyline: San Francisco 49ers (-125), Houston Texans (+105)Spread: Texans -1.5Total: 41.5 points

This game opened at Texans -1.0 with the Game Total set at 41.0.

Be sure to check out DraftKings for all the latest game odds & player props for every matchup this week on the NFL schedule!

Quarterback Matchup for San Francisco at Houston49ers Starting QB: Mac Jones
Last Game: 10/19 vs. Atlanta – 17-26, 152yds, 0 TDs, 1 INT, Sacked 1 time, 5 carries for 11yds
Season: 5GP, 130-194, 1404yds, 6TDs, 4 INTs, Sacked 12 times, 21 carries for 34yds rushing
Texans Starting QB: C.J. Stroud
Last Game: 10/20 at Seattle – 23-49, 229yds, 1 TD, 1 INT, Sacked 3 times, 2 carries for 25yds rushing
Season: 6GP, 125-193, 1305yds, 9 TDs, 4 INTs, Sacked 15 times, 20 carries for 147yds
49ers at Texans team stats, betting trendsThe Texans have lost 18 of their last 20 games against teams with better recordsThe 49ers have covered the spread in their last 3 road games against teams with worse recordsThe OVER is 7-3 in the 49ers’ last 10 games
49ers Player InjuriesQB Brock Purdy (toe) is questionable for Sunday’s gameWR Ricky Pearsall (knee) is questionable for Sunday’s gameCB Deommodore Lenoir (quad) is questionable for Sunday’s gameOT Spencer Burford (knee) has returned to practice from the IR but is questionable for Sunday’s gameC Jake Brendel (hamstring) is questionable for Sunday’s gameLB Luke Gifford (undisclosed) is questionable for Sunday’s gameDE Bryce Huff (hamstring) is doubtful for Sunday’s gameTexans Player InjuriesWR Nico Collins (concussion) is questionable for Sunday’s gameWR Christian Kirk (hamstring) is questionable for Sunday’s gameTE Dalton Schultz (back) is questionable for Sunday’s gameDE Darrell Taylor (illness) is questionable for Sunday’s gameDE Denico Autry (undisclosed) is questionable for Sunday’s gameDE Derek Barnett (ankle) is questionable for Sunday’s game