49ers vs. Texans injury report

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Apr 26, 2025; San Francisco, California, USA; San Francisco 49ers running back Christian McCaffrey (center) sits courtside during the third quarter of game three of first round between the Golden State Warriors and the Houston Rockets for the 2024 NBA Playoffs at Chase Center.

The San Francisco 49ers (5-2) have 16 players on the injury report, including Christian McCaffrey, ahead of their matchup versus the Houston Texans (2-4) at NRG Stadium, on Sunday, Oct. 26 at 1 p.m. ET.

Watch Houston Texans vs. San Francisco 49ers on Fubo! (Regional restrictions may apply)49ers vs Texans TV channel & game infoGame day: Sunday, October 26, 2025Game time: 1 p.m. ETLocation: Houston, TexasStadium: NRG StadiumTV channel: FOXLive stream: Watch on Fubo! (Regional restrictions may apply)Watch Houston Texans vs. San Francisco 49ers on Fubo! (Regional restrictions may apply)Need a news break? Check out the all new PLAY hub with puzzles, games and more!49ers injury reportSpencer Burford | OL (Out)Injury: KneePractice Status: Limited Participation in PracticeBrock Purdy | QB (Out)Injury: ToePractice Status: Limited Participation in Practice2025 Passing: 73-for-48 | 586 Yards | 4 Touchdowns | 4 InterceptionsRicky Pearsall | WR (Out)Injury: KneePractice Status: Did Not Participate In Practice2025 Receiving Stats: 29 Targets | 20 Receptions | 327 Yards | 0 TouchdownsBryce Huff | DL (Out)Injury: HamstringPractice Status: Did Not Participate In Practice2025 Defensive Stats: 4.0 Sacks | 6.0 Tackles for Loss | 19 Tackles | 0 Interceptions | 1 Pass DefendedYetur Gross-Matos | DL (Out)Injury: KneePractice Status: Did Not Participate In PracticeJake Brendel | OL (Out)Injury: HamstringPractice Status: Did Not Participate In Practice2025 Season Stats: 3 Games PlayedDeommodore Lenoir | DB (Questionable)Injury: QuadricepPractice Status: Limited Participation in Practice2025 Defensive Stats: 0.0 Sacks | 3.0 Tackles for Loss | 26 Tackles | 0 Interceptions | 2 Passes DefendedLuke Gifford | LB (Questionable)Injury: HamstringPractice Status: Limited Participation in PracticeTrent Williams | OTInjury: NIR – RestPractice Status: Full Participation in Practice2025 Season Stats: 3 Games PlayedCJ West | DTInjury: ThumbPractice Status: Full Participation in Practice2025 Defensive Stats: 0.0 Sacks | 0.0 Tackles for Loss | 4 Tackles | 0 Interceptions | 0 Passes DefendedUpton Stout | CBInjury: AnklePractice Status: Full Participation in Practice2025 Defensive Stats: 1.0 Sack | 2.0 Tackles for Loss | 25 Tackles | 0 Interceptions | 2 Passes DefendedChristian McCaffrey | RBInjury: NIR – RestPractice Status: Full Participation in Practice2025 Rushing: 132 Attempts | 465 Yards | 3 Touchdowns2025 Receiving Stats: 68 Targets | 53 Receptions | 516 Yards | 3 TouchdownsMac Jones | QBInjury: KneePractice Status: Full Participation in Practice2025 Passing: 194-for-130 | 1,404 Yards | 6 Touchdowns | 4 Interceptions2025 Rushing: 21 Attempts | 34 Yards | 0 TouchdownsJauan Jennings | WRInjury: AnklePractice Status: Full Participation in Practice2025 Receiving Stats: 29 Targets | 14 Receptions | 167 Yards | 1 TouchdownRenardo Green | CBInjury: ToePractice Status: Full Participation in Practice2025 Defensive Stats: 0.0 Sacks | 0.0 Tackles for Loss | 20 Tackles | 0 Interceptions | 5 Passes DefendedKalia Davis | DLInjury: HandPractice Status: Full Participation in Practice49ers insightsThe 49ers’ offense has seen a slight uptick in production over its last three games, tallying 21.7 points per game, compared to its season-long average of 20.7 points per contest.Turning our attention to yardage, San Francisco is amassing 366.6 total yards per game this season, but it has been a tad worse over its last three tilts, averaging 364.7 yards per contest.In the passing game, the 49ers are compiling 271.3 passing yards per game this season, but they’ve declined over their last three tilts, averaging 259.7 passing yards per contest.San Francisco has seen slightly improved production on the ground over its last three matchups, scampering for 105.0 yards per contest, compared to its season-long average of 95.3 rushing yards per game.49ers vs Texans odds

NFL odds courtesy of BetMGM. Odds updated Saturday at 9:29 p.m. ET. For a full list of sports betting odds, access USA TODAY Sports Betting Scores Odds Hub.

Spread Favorite: Texans (-2.5)Moneyline: Texans (-133), 49ers (+112)Total: 42 pointsWatch Houston Texans vs. San Francisco 49ers on Fubo! (Regional restrictions may apply)

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