The San Francisco 49ers (5-2) visit the Houston Texans (2-4) Sunday in Week 8. Kickoff from NRG Stadium in Houston, Texas, is at 1 p.m. ET (FOX). Let’s analyze BetMGM Sportsbook’s NFL odds around the 49ers vs. Texans odds and make our expert NFL picks and predictions for the best bets.

The 49ers share the top spot in the NFC West and are coming off a 20-10 win over the Atlanta Falcons on Sunday Night Football as 1-point home underdogs, with the Under (47) cashing. RB Christian McCaffrey dominated with 199 total yards from scrimmage and 2 TDs.

The Texans had a 2-game winning streak snapped Monday night in a 27-19 road loss to the Seattle Seahawks as 3-point underdogs as the Over (41) cashed. Houston was held to 254 yards of offense and 2-for-15 on third downs. They fell behind 14-0 and never recovered.

The Niners won their last game against the Texans, a 23-7 home win in 2021, covering the 15-point spread as favorites.

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Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 6:33 a.m. ET.

Moneyline (ML): 49ers +115 (bet $100 to win $115) | Texans -140 (bet $140 to win $100)Against the spread (ATS): 49ers +2.5 (-110) | Texans -2.5 (-110)Over/Under (O/U): 42 (O: -110 | U: -110)49ers at Texans key injuries

49ers

OL Jake Brendel (hamstring) outOL Spencer Burford (knee) outLB Luke Gifford (hamstring) questionableDL Yetur Gross-Matos (knee, hamstring) outDL Bryce Huff (hamstring) outDB Deommodore Lenoir (quadricep) questionableWR Ricky Pearsall (knee) outQB Brock Purdy (toe) out

Texans

DL Demico Autry (knee) questionableWR Nico Collins (concussion) outWR Christian Kirk (hamstring) out49ers at Texans picks and predictionsPrediction

49ers 20, Texans 17

The 49ers are 3-1 on the road. The Texans have the league’s No. 1 defense in points allowed (14.7 points per game allowed), but they struggle scoring points, averaging only 21.2 PPG, ranking 21st.

The Niners keep dealing with injuries on both sides of the ball, but they find ways to win. In their game last week, it was the big game from McCaffrey.

The Texans have been held under 20 points 4 times. The 49ers have allowed 21 or fewer points 4 times. And with the Texans missing WRs Collins and Kirk, they will have to be one-dimensional.

BET 49ers (+115).

The Texans have failed to cover the spread in any of their losses, so if you think they will cover, they will win. If they don’t win, they don’t cover. And when you can bet the plus odds on the ML backing the 49ers, the spread isn’t that appealing.

PASS.

The Texans have had their last 2 games hit the Over, but their first 4 games of the season all hit the Under.

The 49ers’ last game had a total of only 30 points.

BET UNDER 42 (-110).

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