April 11, 2026, 10:00 a.m. ET
The San Francisco Giants (6-8) and the Baltimore Orioles (6-7) play the second game of their 3-game series Saturday at Oriole Park at Camden Yards in Baltimore, Maryland. First pitch is scheduled for 7:15 p.m. ET (FOX). Let’s analyze MLB odds around the Giants vs. Orioles odds and make our expert MLB picks and predictions for the best bets.
Season series: Giants lead 1-0
The Giants opened the series with a 6-3 win over the Orioles as +100 road underdogs, with the Over (8.5) cashing. SP Landen Roupp (1 ER, 5 H, 2 BB, 4 K) delivered 6 strong innings, while SS Willy Adames and RF Jung Hoo Lee homered. San Francisco has now won 3 straight.
The Orioles saw their 3-game win streak snapped Friday. SP Shane Baz (5 IP, 3 ER, 9 H, 2 BB, 4 K, 1 HR) continued to struggle, remaining winless since signing a contract extension March 27. SS Gunnar Henderson provided a 2-run homer, but 1B Pete Alonso went hitless with 2 strikeouts, leaving 3 runners on base.
Watch MLB on Fubo!Giants at Orioles projected starters
RHP Logan Webb vs. RHP Chris Bassitt
Webb (1-1, 5.00 ERA) is making his fourth start. He has a 1.39 WHIP, 3.0 BB/9 and 7.5 K/9 through 18 innings.
Last start: No-decision, 7 IP, 1 ER, 7 H, 1 BB, 3 K (92 pitches) in 5-2 loss against the New York Mets on SundayLast start vs. Orioles: No-decision, 5 IP, 3 ER, 4 H, 2 BB, 8 K in 5-3 road defeat Sept. 19, 2024Career vs. Orioles: 0-1, 4.50 ERA (12 IP, 6 ER), 0.92 WHIP, 8 H, 3 BB, 14 K in 2 starts2025 on road: 7-7, 3.36 ERA (91 IP, 34 ER), 1.25 WHIP, 9.7 K/9 in 15 starts
Bassitt (0-2, 14.21 ERA) is making his third start. He has a 2.84 WHIP, 8.5 BB/9 and 4.3 K/9 through 6 1/3 innings.
Last start: Loss, 2 IP, 6 ER, 6 H, 2 BB, 0 K (62 pitches) in 8-2 road loss at Pittsburgh on SundayLast start vs. Giants: Win, 6 1/3 IP, 0 ER, 10 H, 0 BB, 5 K in 4-0 home victory July 18, 2025, as a member of the Toronto Blue JaysCareer vs. Giants: 4-2, 3.91 ERA (46 IP, 20 ER), 1.30 WHIP, 46 H, 14 BB, 49 K in 8 starts2025 at home: 8-0, 2.71 ERA (93 IP, 28 ER), 1.17 WHIP, 9.7 K/9 in 16 startsGiants at Orioles odds
Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 9:50 a.m. ET.
Moneyline (ML): Giants -120 (bet $120 to win $100) | Orioles +100 (bet $100 to win $100)Run line (RL)/Against the spread (ATS): Giants -1.5 (+145) | Orioles +1.5 (-175)Over/Under (O/U): 7.5 (O: +100 | U: -120)
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Giants at Orioles picks and predictionsPrediction
Giants 5, Orioles 4
BET GIANTS (-120).
The Giants come into this matchup with momentum, winning 3 straight while outscoring opponents 17-3. After a slow start at the plate, the offense is beginning to find its rhythm, with contributions from Adames and Lee leading the way.
On the mound, Webb gives San Francisco a clear edge, while Baltimore turns to Bassitt, who has struggled early with command and limiting damage. That sets up favorable scoring chances for the Giants, especially against left-handed matchups.
With better recent form, a reliable starter and an offense starting to click, San Francisco is in a strong position to keep its streak going and deliver value on the moneyline.
PASS. I don’t have any interest in the run line for this game.
BET OVER 7.5 (+100).
Eight straight meetings between the Giants and Orioles have gone Over, and the trend continues to point that way. San Francisco has scored 5 plus runs in 3 straight games, and the Over is 6-2-2 in its last 10. With Bassitt struggling early, both teams should find scoring opportunities again.
For more sports betting picks and tips, check out SportsbookWire.com and BetFTW.