Coach Lincoln Riley and the 14th-ranked USC Trojans kick off the 2026 season against the visiting San Jose State Spartans on Saturday. USC, which finished fourth in the Big Ten at 7-2 and were 9-4 overall, is looking to challenge for the conference championship for the first time since joining the Big Ten in 2024. San Jose State, meanwhile, is looking to improve on its 3-9 overall and 2-6 mark in the Mountain West last year. The Spartans tied for ninth in 2025. Visit our DraftKings promo code review and get $150 in bonus bets instantly as a new user after $5+ in wagers here:
Kickoff is set for 3 p.m. ET at Los Angeles Memorial Coliseum. The Trojans are 38.5-point favorites in the latest San Jose State vs. USC odds, while the over/under is 60.5.
Before making any San Jose State vs. USC picks, check out the college football predictions from the SportsLine Projection Model.
The model simulates every FBS game 10,000 times. It is on a 31-19 run on top-rated CFB money-line picks since the 2024 season, and it has been upgraded for the 2026 season to even better factor in the transfer portal!
The model has simulated San Jose State vs. USC 10,000 times and the results are in. The model is going Over on the total, and it also says one side of the spread hits in nearly 60% of simulations!
So who wins San Jose State vs. USC, and which side of the spread hits nearly 60% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that is on a 31-19 run on top-rated CFB picks!
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