The San Francisco Giants try to avoid losing five straight games going into Game 2 of this series against the St. Louis Cardinals on Tuesday.

The St. Louis Cardinals go for the series win on Tuesday night in Game 2 when they host the San Francisco Giants. The Cardinals won the opener with a narrow 2-1 victory. It was the first win of the year for the Cardinals against the Giants. San Francisco swept at home in the first series less than a week ago. Ever since that series, the Giants have now lost four straight games after getting swept at home by the San Diego Padres during the weekend. The Giants are now 62-89, with a 26-50 record at home, as they try to play spoiler against the Cardinals. That is because St. Louis still has a very slim chance at a playoff berth. St. Louis likely will have to win out the rest of the season to catch up to the Padres for the last NL Wild Card slot. The Cardinals are 74-75 overall with a 37-39 record at home, which puts them seven games back of San Diego with their Wild Card Elimination number at five. The good news for St. Louis is it has a chance to win four of its last five games today after winning its series against the Chicago White Sox over the weekend. The Cardinals are the -168 favorites to win this series at home tonight. St. Louis will try to keep it rolling by starting one of its best, Andre Pallante, who is 12-6 with a 3.45 ERA in 146 innings. The Giants will start Blade Tidwell, who is going for the first win of his first year in San Francisco. The righty is 0-2 with a 4.82 ERA in 46.2 innings.

How to Watch San Francisco Giants vs St. Louis Cardinals Today:

Game Date: Tuesday, Sep. 15, 2026

Game Time: 7:45 p.m. ET

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TV: MLB.TV – San Francisco Giants, NBC Sports Bay Area, St. Louis Cardinals

Location: Busch Stadium – St. Louis, MO

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It was the Quinn Mathews show in the opener in St. Louis on Monday. The Cardinals’ lefty was throwing a no-hitter into the sixth inning, and he earned the win to improve to 2-3 on the season. Mathews finished his day by giving up one run in 6.2 innings on four hits, and he struck out eight. Mathews got all the run support he would need when St. Louis scored two in the fifth inning. Alec Burleson hit an RBI single to start things off as he continues to add to his MLB-best 110 RBIs. Leo Bernal went on to drive home what turned out to be the game-winning run soon after on a single. The Giants scored in the very next inning on an RBI single from Jonah Cox. But San Francisco couldn’t get any closer, as closer Riley O’Brien earned his 37th save of the season with two strikeouts in the ninth.

What Time Is the San Francisco Giants vs St. Louis Cardinals Game On?

The San Francisco Giants vs St. Louis Cardinals game will take place on Tuesday, September 15, 2026, at 7:45 p.m. ET. Tune in and catch some great MLB action.

What Channel Is the San Francisco Giants vs St. Louis Cardinals Game On?

Looking to watch this game? Fans can tune into MLB.TV – San Francisco Giants, NBC Sports Bay Area, St. Louis Cardinals to see the action. Make sure you subscribe to Fubo now to watch this matchup, as well as numerous other sports leagues.

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