San Francisco (6-4) will face off against their NFC West rival, the Arizona Cardinals (3-6) in a matchup on Sunday, November 16, 2025 at State Farm Stadium. The spread predicts an evenly-matched game, with the 49ers favored to win by 3 points. The over/under in the contest is set at 48.5 points.
The 49ers lost versus the Los Angeles Rams in their most recent game, 42-26.
Niners quarterback Mac Jones went 33-for-39 for 319 yards, with three TDs and one INT, versus the Rams.
In their last contest, the Cardinals lost against the Seattle Seahawks, 44-22.
49ers vs Cardinals betting information
NFL odds courtesy of BetMGM Sportsbook. Odds updated Saturday at 4:47 p.m. ET. For a full list of sports betting odds, access USA TODAY Sports Betting Scores Odds Hub.
Need a news break? Check out the all new PLAY hub with puzzles, games and more!Spread favorite: San Francisco (-3)Moneyline: San Francisco (-172), Arizona (+144)Total: 48.5 points49ers betting insightsIn away games, San Francisco is 4-2 against the spread and 4-2 overall.The 49ers have covered the spread five times this season (5-5-0).Away from home, San Francisco is unbeaten ATS (1-0) as 3-point favorites or more.The 49ers have an ATS record of 1-1 when playing as at least 3-point favorites.In six road games this year, San Francisco has hit the over four times.This season, 49ers games have hit the over six times.49ers leadersBrock Purdy: 586 PASS YDS / 293 YPG / 65.8% / 4 TD / 4 INT / 7 CAR / 30 RUSH YDS / 0 TDChristian McCaffrey: 180 CAR / 626 YDS / 62.6 YPG / 4 TD / 69 REC / 692 YDS / 69.2 YPG / 4 TDBrian Robinson Jr.: 49 CAR / 238 YDS / 23.8 YPG / 2 TD / 6 REC / 15 YDS / 1.5 YPG / 0 TDKendrick Bourne: 31 REC / 482 YDS / 53.6 YPG / 0 TDRicky Pearsall: 20 REC / 327 YDS / 81.8 YPG / 0 TD49ers vs Cardinals game infoDate: Sunday, November 16, 2025Time: 4:05 p.m. ETCity: Glendale, ArizonaVenue: State Farm StadiumTV channel: FOXLive stream: Watch on Fubo (Regional restrictions may apply)Watch San Francisco 49ers vs. Arizona Cardinals on Fubo! (Regional restrictions may apply)
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