MWC foes meet when the San Diego State Aztecs (8-2) and the San Jose State Spartans (3-7) square off on Saturday, November 22, 2025 at Snapdragon Stadium. The contest will be broadcast on Fox Sports 1, at 10:30 p.m. ET. Below, we analyze BetMGM Sportsbook’s lines around San Diego State vs. San Jose State odds, and make our expert college football picks and predictions.
The Aztecs beat the Boise State Broncos 17-7 in their last outing. Last time out, the Spartans were defeated by the Nevada Wolf Pack 55-10. Jayden Denegal threw for 17 yards, with no touchdowns and no interceptions on 6-of-10 passing (60.0%) for the Aztecs in that matchup against the Broncos. He also added five carries for 16 yards and two rushing touchdowns. Lucky Sutton took 25 carries for 150 yards (6.0 yards per carry), while adding one reception for -4 yards in the passing game. Mikey Welsh had three receptions for 22 yards (7.3 per catch) against the Broncos.
Walker Eget totaled 74 passing yards while going 11-for-23 with no touchdowns and three interceptions for the Spartans against the Wolf Pack. He added six carries for 35 yards. Steve Chavez-Soto put together an eight-carry, 47-yard game (5.9 yards per attempt). Kyri Shoels caught three passes on eight targets for 47 yards (15.7 yards per reception).
Watch San Diego State vs. San Jose State on Fubo! (Regional restrictions may apply)San Diego State vs. San Jose State odds
Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Friday at 12:25 p.m.
Moneyline (ML): San Diego State -510 (Bet $510 to win $100) | San Jose State +384 (Bet $100 to win $384)Against the spread (ATS): San Diego State -12.5 (-109) | San Jose State +12.5 (-111)Over/Under (O/U): 50.5 (O: -109 | U: -111)How to make San Diego State vs. San Jose State picksPrediction
San Diego State 35, San Jose State 12
MoneylineMoneyline pick: San Diego State -510San Diego State has won 87.5% of the games this season when it was the moneyline favorite (7-1).The Aztecs have played as a moneyline favorite of -510 or shorter in just one game this season, which they won.This season, San Jose State has been listed as the underdog in three games and failed to win any of those contests.The Spartans have played as an underdog of +384 or more once this season and lost that game.Against the spreadATS pick: San Diego State -12.5Against the spread, the Aztecs are 8-2-0 this year.San Diego State is unbeaten ATS (1-0) as a 12.5-point favorite or greater this year.The Spartans have four wins in 10 contests against the spread this year.San Jose State has covered every time (1-0) as a 12.5-point or greater underdog this year.Over/UnderO/U pick: Under 50.5 pointsAztecs games have had a combined total of more than 50.5 points two times this season (in 10 outings).The Spartans have combined with their opponents to score more than 50.5 points in seven of 10 games this season.These two teams average 49.4 points per game combined, 1.1 less than this game’s total.These teams together allow 44.9 points per game, 5.6 fewer than this matchup’s over/under.The average point total in Aztecs games this season is 45.1, 5.4 points fewer than this matchup’s over/under.Spartans games this year have had a 55.0-point total on average, 4.5 more points than this matchup’s over/under.
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