Dec. 10, 2025, 11:46 a.m. ET
The Tennessee Titans are on the road again this week when they face the San Francisco 49ers at Levi’s Stadium in Santa Clara, California, at 3:25 p.m. CST.
The Titans and 49ers have only met 15 times historically, with the 49ers owning the record, 9-6. The last time they met, though, was in 2021. Kyle Shanahan was the head coach at the time, but he did not have Brock Purdy as his quarterback. The Titans had Mike Vrabel and Ryan Tannehill at the time and came away with a 20-17 victory.
Both of these teams are very different from their last matchup, which means the outcome could very well be different, too.
If you reside in the blue area of the map, you’ll see the Titans and 49ers on your local FOX station.
Getting the call for the game is Adam Amin (play-by-play), Drew Brees (analyst), and Kristina Pink (sideline reporter).
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Information courtesy of 506sports.com.