Updated Dec. 13, 2025, 5:47 p.m. PT
San Francisco (9-4) brings a three-game winning streak into a matchup with Tennessee (2-11) on Sunday, December 14, 2025 at Levi’s Stadium. The 49ers are without a doubt the favorites in this one, with the line posted at 12.5 points. An over/under of 44.5 points has been set for the outing.
The 49ers beat the Cleveland Browns, 26-8, in their last contest.
Against the Browns, Brock Purdy completed 16 of 29 passes for 168 yards, with one touchdown and no interceptions, for the Niners.
Against the Cleveland Browns in their last contest, the Titans won 31-29.
49ers vs Titans betting information
NFL odds courtesy of BetMGM Sportsbook. Odds updated Saturday at 8:47 p.m. ET. For a full list of sports betting odds, access USA TODAY Sports Betting Scores Odds Hub.
Need a news break? Check out the all new PLAY hub with puzzles, games and more!Spread favorite: San Francisco (-12.5)Moneyline: San Francisco (-877), Tennessee (+592)Total: 44.5 points49ers betting insightsAt home this season, San Francisco has two wins against the spread and is 3-2 overall.The 49ers have gone 8-5-0 against the spread this season.In five home games this season, San Francisco has hit the over twice.49ers games have finished with a final combined score above the over/under seven times this season.49ers leadersPurdy: 1,147 PASS YDS / 229.4 YPG / 66.2% / 9 TD / 7 INTChristian McCaffrey: 237 CAR / 849 YDS / 65.3 YPG / 8 TD / 85 REC / 806 YDS / 62 YPG / 5 TDBrian Robinson Jr.: 72 CAR / 328 YDS / 25.2 YPG / 2 TD / 7 REC / 19 YDS / 1.5 YPG / 0 TDKendrick Bourne: 31 REC / 482 YDS / 48.2 YPG / 0 TDJauan Jennings: 41 REC / 458 YDS / 41.6 YPG / 5 TD49ers vs Titans game infoDate: Sunday, December 14, 2025Time: 4:25 p.m. ETCity: Santa Clara, CaliforniaVenue: Levi’s StadiumTV channel: FOXLive stream: Watch on Fubo (Regional restrictions may apply)Watch San Francisco 49ers vs. Tennessee Titans on Fubo! (Regional restrictions may apply)
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