Seahawks at 49ers odds, picks and predictions

Jan. 3, 2026, 2:54 a.m. ET

The Seattle Seahawks (13-3) visit the San Francisco 49ers (12-4) on Saturday in a game with huge stakes. Kickoff from Levi’s Stadium in Santa Clara is set for 8 p.m. ET (ABC, ESPN). Let’s analyze BetMGM Sportsbook’s NFL odds around the Seahawks vs. 49ers odds and make our expert NFL picks and predictions for the best bets.

The winner of this game will win the NFC West and clinch the No. 1 seed in the conference, earning a first-round playoff bye and home-field advantage until the Super Bowl.

The Seahawks have won their last 6 games, most recently beating the Carolina Panthers 27-10 on Sunday as 6.5-point road favorites with the Under (43) cashing. They held the Panthers to only 139 total yards and had a pair of takeaways.

The 49ers are also riding a 6-game winning streak. They beat the Chicago Bears on Sunday 42-38 as 3.5-point home favorites with the Over (51.5) cashing. QB Brock Purdy threw 3 touchdown passes and rushed for 2 more, and RB Christian McCaffrey had 181 total yards from scrimmage and a score.

The 49ers beat the Seahawks 17-13 in Seattle in Week 1 as 1-point favorites. The Under (43.5) hit.

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Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Saturday at 2:40 a.m. ET.

Moneyline (ML): Seahawks -135 (bet $135 to win $100) | 49ers +115 (bet $100 to win $115)Against the spread (ATS): Seahawks -2.5 (-110) | 49ers +2.5 (-110)Over/Under (O/U): 48 (O: -110 | U: -110)Seahawks at 49ers key injuries

Seahawks

S Coby Bryant (knee) doubtfulLT Charles Cross (hamstring) outOT Josh Jones (ankle, knee) questionable

49ers

TE George Kittle (ankle) questionableWR Ricky Pearsall (ankle, knee) questionableCB Upton Stout (concussion) questionableDE Keion White (groin) questionableLT Trent Williams (hamstring) questionableSeahawks at 49ers picks and predictionsPrediction

49ers 30, Seahawks 27

The 49ers have been rolling offensively, averaging 42.3 points per game over their last 3 contests.

Seattle, though, has been fantastic defensively, allowing only 35 combined points in 4 of its last 5 games. However, the Seahawks allowed 37 to the LA Rams on Dec. 18 and the 49ers rival the Rams in offensive performance.

But when it comes to big games, it will come down to whether Seahawks QB Sam Darnold can keep up his play from this season, or whether he will do what he did last year in this same scenario. Darnold, who has thrown 3 interceptions and fumbled twice in his last 2 games, started for Minnesota in a Week 18 game that determined who won the NFC North last season. Darnold had his worst start of the season, throwing for 166 yards with no scores as the Vikings lost in Detroit, 31-9.

The 49ers are more battle-tested when it comes to big games. They are 4-1 against division opponents this season and 9-2 in conference games.

BET 49ERS (+115).

The 49ers have been underdogs 5 times this season. They are 2-3 ATS and both covers were outright wins.

With plus odds on the Niners’ ML, that is the better play here.

PASS.

Their first meeting this season had a total of 30. But the total has gone over 50 in the Niners’ last 3 games and 6 of their last 8.

Four of the Seahawks’ last 5 games have not reached 48 total points but 4 of their last 9 have — including 2 of their last 3 games in the NFC West.

BET OVER 48 (-110).

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Seahawks at 49ers odds, picks and predictions

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