Jan. 16, 2026Updated Jan. 17, 2026, 1:48 a.m. PT
The San Francisco 49ers are significant underdogs (+7) in this year’s Divisional Round of the NFC playoffs, where they will face the Seattle Seahawks. The matchup will kick off from Lumen Field in Seattle, Washington on January 17, 2026, starting at 8 p.m. ETand airing on FOX. The over/under is 45 in the contest.
The 49ers’ last game was versus the Philadelphia Eagles, and they won by a score of 23-19.
The Niners’ Brock Purdy went 18-for-31 for 262 yards versus the Eagles, with two TDs and two INTs.
The Seahawks will be facing the 49ers for the second time in a row, with the Seattle Seahawks winning the previous matchup on January 3, 2026, .
49ers vs Seahawks betting information
NFL odds courtesy of BetMGM Sportsbook. Odds updated Saturday at 4:48 a.m. ET. For a full list of sports betting odds, access USA TODAY Sports Betting Scores Odds Hub.
Expert NFL picks: Exclusive betting insights only at USA TODAY.Spread favorite: Seattle (-7)Moneyline: Seattle (-339), San Francisco (+272)Total: 45 points49ers betting insightsIn away games, San Francisco is 7-2 against the spread and 7-2 overall.Against the spread, the 49ers were 11-6-0 during the regular season and are 1-0-0 in the playoffs.San Francisco is unbeaten ATS (1-0) as 7-point underdogs or more on the road.The 49ers are unbeaten ATS (1-0) as 7-point underdogs or more during the regular season and playoffs.San Francisco has hit the over in six of nine road games this season.The 49ers had 10 of their 17 games hit the over in the regular season, and zero of one in the playoffs.49ers leadersPurdy: 2,167 PASS YDS / 240.8 YPG / 69.4% / 20 TD / 10 INT / 33 CAR / 147 RUSH YDS / 3 TDChristian McCaffrey: 311 CAR / 1,202 YDS / 70.7 YPG / 10 TD / 102 REC / 924 YDS / 54.4 YPG / 7 TDBrian Robinson Jr.: 92 CAR / 400 YDS / 23.5 YPG / 2 TD / 8 REC / 25 YDS / 1.5 YPG / 0 TDJauan Jennings: 55 REC / 643 YDS / 42.9 YPG / 9 TDKendrick Bourne: 37 REC / 551 YDS / 39.4 YPG / 0 TD49ers vs Seahawks game infoDate: Saturday, January 17, 2026Time: 8 p.m. ETCity: Seattle, WashingtonVenue: Lumen FieldTV channel: FOXLive stream: Watch on Fubo (Regional restrictions may apply)Watch Seattle Seahawks vs. San Francisco 49ers on Fubo! (Regional restrictions may apply)
Our team of savvy editors independently handpicks all recommendations. If you purchase through our links, the USA Today Network may earn a commission. Prices were accurate at the time of publication but may change.
Gambling involves risk. Please only gamble with funds that you can comfortably afford to lose.  While we do our utmost to offer good advice and information we cannot be held responsible for any loss that may be incurred as a result of gambling.  We do our best to make sure all the information that we provide on this site is correct. However, from time to time mistakes will be made and we will not be held liable. Please check any stats or information if you are unsure how accurate they are. No guarantees are made with regards to results or financial gain. All forms of betting carry financial risk and it is up to the individual to make bets with or without the assistance of information provided on this site and we cannot be held responsible for any loss that may be incurred as a result of following the betting tips provided on this site.  Past performances do not guarantee success in the future and betting odds fluctuate from one minute to the next. The material contained on this site is intended to inform, entertain and educate the reader and in no way represents an inducement to gamble legally or illegally or any sort of professional advice.
Gannett may earn revenue from sports betting operators for audience referrals to betting services. Sports betting operators have no influence over nor are any such revenues in any way dependent on or linked to the newsrooms or news coverage. Terms apply, see operator site for Terms and Conditions. If you or someone you know has a gambling problem, help is available. Call the National Council on Problem Gambling 24/7 at 1-800-GAMBLER (NJ, OH), 1-800-522-4700 (CO), 1-800-BETS-OFF (IA), 1-800-9-WITH-IT (IN). Must be 21 or older to gamble. Sports betting and gambling are not legal in all locations. Be sure to comply with laws applicable where you reside. It is your sole responsibility to act in accordance with your local laws.