49ers at Seahawks NFC Divisional Round odds, picks and predictions

Jan. 16, 2026, 4:05 p.m. ET

The San Francisco 49ers (12-5) face the Seattle Seahawks (14-3) in an NFC Divisional Round matchup Saturday. Kickoff from Lumen Field in Seattle, Washington, is set for 8 p.m. ET (FOX). Let’s analyze BetMGM Sportsbook’s NFL odds around the 49ers vs. Seahawks odds and make our expert NFL picks and predictions for the best bets.

San Francisco upset the defending Super Bowl champion Philadelphia Eagles 23-19 in the Wild Card round last week, covering as a 5.5-point road underdog as the Under (44.5) hit. The Niners were banged up heading into the contest, and they lost TE George Kittle early in the game to an achilles injury, but they were still able to lead in total yards. The Niners went 6-of-11 (54%) on third down. QB Brock Purdy hit 18 of 31 passes for 262 yards with 2 TDs and 2 INTs.

Seattle is coming off a bye after finishing as the top seed in the NFC. The Seahawks won 7 straight games to end the regular season, putting up at least 25 points in 5 of those 7 wins and holding teams to single digits in 4 of the last 6 of those wins. QB Sam Darnold was injured in practice Thursday and was added to the injury report with an oblique injury, though he is expected to play.

In 2 matchups this season, including a critical Week 18 matchup, these squads split. The Seahawks won 13-3 while covering as a 2.5-point road favorite as the Under (48.5) cashed in Week 18 to win the NFC West and top seed. The Niners won 17-13 while covering in Seattle in Week 1. These squads have met twice in the playoffs, most recently in a 2023 Wild Card matchup that San Francisco dominated 41-23 at home.

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Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Friday at 4:04 p.m. ET.

Moneyline (ML): 49ers +260 (bet $100 to win $260) | Seahawks -325 (bet $325 to win $100)Against the spread (ATS): 49ers +7 (-110) | Seahawks -7 (-110)Over/Under (O/U): 45 (O: -110 | U: -110)49ers at Seahawks key injuries

49ers

S Ji’Ayir Brown (hamstring) outLB Luke Gifford (quad) questionableWR Ricky Pearsall (knee) questionableLB Fred Warner (ankle) outLB Dee Winters (ankle) questionable

Seahawks

TE Elijah Arroyo (knee) outQB Sam Darnold (oblique) questionableOT Josh Jones (knee) out49ers at Seahawks picks and predictionsPrediction

Seahawks 24, 49ers 18

PASS.

I like Seattle to win, but the Seahawks are not worth the risk of backing as a -325 favorite, especially without seeing how Darnold will play on this injury. Pass here and bet on the safer spread and/or total for this game.

LEAN 49ERS +7 (-110).

San Francisco has covered the spread in 7 of its last 10 games, including in the Wild Card game, while the Seahawks are just 2-2 ATS in their last 4 games. The Niners are also 6-3 ATS in their last 9 matchups against Seattle.

The Niners have major injuries, but their defense is still elite, and they will be able to get pressure against this very weak Seahawks offensive line. On the other side, expect RB Christian McCaffrey to get a lot of touches and for some creative playcalls to give the Niners life throughout the game.

Keep in mind that while San Francisco has been great ATS lately, all 6 of its last 7 regular season games in which the Niners covered ATS came against non-playoff teams.

BET UNDER 45 (-110).

The Under has hit in back-to-back games for San Francisco, also sitting at 2-1 in San Francisco’s last 3 road games. For Seattle, the Under is 3-1 in its last 4 games. The Under has also hit in all of the last 3 matchups between these squads.

With this being a matchup between divisional rivals, both of whom are elite defensively, I expect for this to be a low-scoring and tight contest throughout.

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49ers at Seahawks NFC Divisional Round odds, picks and predictions

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