Larkin last played March 6 as he’s been nursing what appeared to be a leg injury he suffered that day against the Florida Panthers.
The 29-year-old has 55 points (28 goals, 27 assists) in 63 games on the season.
The Red Wings sat one point back of the New York Islanders for the second and final wild-card spot in the Eastern Conference heading into Tuesday’s game. The Senators are one point behind Detroit.