The San Francisco 49ers (5-2) will look to upset the Houston Texans (2-4) on Sunday, October 26, 2025 at NRG Stadium. The spread foretells a close game, with the Texans favored by 2.5 points. The over/under is 42 in the outing.
In their last game, the 49ers won versus the Atlanta Falcons, 20-10.
Niners QB Mac Jones went 17-for-26 for 152 yards, with no TDs and one INT, versus the Falcons.
Against the Seattle Seahawks in their most recent contest, the Texans lost 27-19.
49ers vs Texans betting information
NFL odds courtesy of BetMGM Sportsbook. Odds updated Saturday at 8:47 p.m. ET. For a full list of sports betting odds, access USA TODAY Sports Betting Scores Odds Hub.
Need a news break? Check out the all new PLAY hub with puzzles, games and more!Spread favorite: Houston (-2.5)Moneyline: Houston (-133), San Francisco (+112)Total: 42 points49ers betting insightsAway from home, San Francisco is 3-1 against the spread and 3-1 overall.The 49ers have covered the spread four times this year (4-3-0).San Francisco has one win ATS (1-1) as 2.5-point underdogs or more away from home.In games they have played as 2.5-point underdogs or more, the 49ers have an ATS record of 1-1.In three of four road games this season, San Francisco has gone over the total.49ers games have gone over the total four times this year.49ers leadersJones: 1,404 PASS YDS / 280.8 YPG / 67% / 6 TD / 4 INTChristian McCaffrey: 132 CAR / 465 YDS / 66.4 YPG / 3 TD / 53 REC / 516 YDS / 73.7 YPG / 3 TDBrian Robinson Jr.: 36 CAR / 144 YDS / 20.6 YPG / 0 TD / 5 REC / 11 YDS / 1.6 YPG / 0 TDKendrick Bourne: 25 REC / 385 YDS / 64.2 YPG / 0 TDRicky Pearsall: 20 REC / 327 YDS / 81.8 YPG / 0 TD49ers vs Texans game infoDate: Sunday, October 26, 2025Time: 1 p.m. ETCity: Houston, TexasVenue: NRG StadiumTV channel: FOXLive stream: Watch on Fubo (Regional restrictions may apply)Watch Houston Texans vs. San Francisco 49ers on Fubo! (Regional restrictions may apply)
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