The San Francisco 49ers and the New York Giants are set to clash this Sunday, November 2, 2025, in an anticipated NFL Week 9 matchup at MetLife Stadium, kicking off at 1 p.m. EST. Oddsmakers have installed the 49ers as the road favorites, with the current odds reflecting a tight contest: San Francisco is listed at a -2.5 spread (-120) and a -152 moneyline. The home underdog Giants stand at +2.5 (+100) and +130, signaling expectations for a very competitive game. The over/under for the contest is currently set at 48.5 points, with both the Over and Under priced equally at -105.

Expert analysis from Dimers, derived from 10,000 game simulations, predicts the 49ers are the more likely victor, assigning them a 59% chance of winning and projecting a final score of 49ers 25, Giants 22. Despite the 49ers being the predicted winner, the modeling’s best betting recommendation leans toward the underdog, advising a wager on the Giants +2.5 (+100). The preview also points to key players who will impact the outcome, with San Francisco running back Christian McCaffrey projected for 79 rushing yards and a high probability of scoring, while players like Wan’Dale Robinson and Tyrone Tracy will be critical components of the Giants’ offensive strategy.

49ers vs. Giants betting preview

Utilize the interactive widget below to view the current spread, total, and moneyline odds and probabilities for the 49ers-Giants game at MetLife Stadium.

This prediction and best bet for Sunday’s NFL matchup between the 49ers and Giants is from Dimers.com, a leader in sports betting predictions.

Check out all the important details on today’s game, as well as the best odds sourced from the top sportsbooks in the country.

Game details

Key information on the 49ers vs. Giants matchup, including where the game is and what time it kicks off.

Teams: San Francisco 49ers vs. New York GiantsDate: Sunday, November 2, 2025Kickoff: 1 p.m. ESTLocation: MetLife StadiumNFL standings: Current NFL division standingsNFL injuries: Check the latest updates to the official NFL injury reportOdds

The latest and best odds for the NFL contest between the 49ers and Giants.

Spread: 49ers -2.5 (-120), Giants +2.5 (+100)Moneyline: 49ers -152, Giants +130Total: Over/Under 48.5 (-105/-105)

The odds and lines featured in this article are the best available from selected sports betting sites at the time of publication and are subject to change.

Expert prediction: 49ers vs. Giants

Leveraging state-of-the-art data analysis and machine learning, the experts at Dimers have performed 10,000 simulations of Sunday’s 49ers vs. Giants game.

According to Dimers’ popular predictive analytics model, the 49ers are more likely to beat the Giants at MetLife Stadium. This prediction is based on the model giving the 49ers a 59% chance of winning the game.

Furthermore, Dimers predicts that the bookmakers have gotten it right and the 49ers and Giants each have a 50% chance of covering the spread, while the 48.5-point over/under is also considered an equal 50-50 chance of hitting.

These predictions and probabilities are accurate at the time of publication but are subject to potential changes.

49ers vs. Giants best bet

Our top pick for the 49ers vs. Giants Week 9 NFL game is to bet on the Giants +2.5 (+100).

This betting advice is based on comprehensive modeling and valuable wagering intelligence, designed to bring you the best possible plays.

Score prediction for 49ers vs. Giants

Dimers’ projected final score for the San Francisco vs. NY Giants game on Sunday has the 49ers winning 25-22.

This expert prediction is based on each team’s average score following 10,000 game simulations, offering a glimpse into the potential outcome.

NFL player props are an enjoyable way to wager on Sunday’s game without necessarily betting on its outcome.

This article features the most likely first and anytime touchdown scorers for the 49ers and Giants, along with projected player stats.

San Francisco 49ersFirst touchdown scorer predictionsChristian McCaffrey: 16.8% probabilityGeorge Kittle: 7.8% probabilityJauan Jennings: 6.1% probabilityAnytime touchdown predictionsChristian McCaffrey: 63.7% probabilityGeorge Kittle: 37.4% probabilityJauan Jennings: 30.8% probabilityProjected box score leadersQB passing yards: Brock Purdy, 239 yardsReceiving yards: George Kittle, 53 yardsRushing yards: Christian McCaffrey, 79 yardsNew York GiantsFirst touchdown scorer predictionsTyrone Tracy: 8.7% probabilityWan’Dale Robinson: 8.0% probabilityJaxson Dart: 5.7% probabilityAnytime touchdown predictionsTyrone Tracy: 40.7% probabilityWan’Dale Robinson: 37.9% probabilityJaxson Dart: 28.8% probabilityProjected box score leadersQB passing yards: Jaxson Dart, 215 yardsReceiving yards: Wan’Dale Robinson, 56 yardsRushing yards: Tyrone Tracy, 50 yardsNFL Week 9: 49ers vs. Giants

Get ready for Sunday’s matchup between the 49ers and Giants in Week 9 of the National Football League season at MetLife Stadium, which is scheduled to start at 1 p.m. EST. We emphasize that all of the NFL predictions and NFL best bets on this page are derived from 10,000 data-driven simulations of the 49ers vs. Giants game, and they are correct at the time of publication. They are intended to assist you make better decisions when placing bets at online sportsbooks.

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