May 11, 2026, 2:49 p.m. ET
The San Francisco Giants (16-24) and the Los Angeles Dodgers (24-16) open a 4-game series Monday at Dodger Stadium in Los Angeles, California. First pitch is scheduled for 10:10 p.m. ET. Let’s analyze MLB odds around the Giants vs. Dodgers odds and make our expert MLB picks and predictions for the best bets.
Season series: Giants lead 2-1
The Giants picked up a 7-6 win Sunday against the Pittsburgh Pirates as moderate favorites (-124) as the Over (8) cashed, clinching the series 2-1. SS Willy Adames went 3 for 4 with a double and 2 RBIs, while LF Heliot Ramos went 2 for 6 with a double, home run, 3 runs scored and 2 RBIs.
The Dodgers suffered a 7-2 loss Sunday against the Atlanta Braves as moderate favorites (-136), their second straight setback by that score. 3B Max Muncy had the big blow, smacking his 10th HR, while finishing with 2 RBIs. The Under (9.5) cashed in the series finale, and it has alternated with the Over in each of the past 7 games since May 3.
These teams met at Oracle Park in San Francisco April 21-23, and each of the games had 4 or fewer runs scored, with an average of just 3.4 combined runs per game in the series. The Under easily cashed in all 3 meetings, with the Giants winning 2 of them.
Watch MLB on Fubo!Giants at Dodgers projected starters
RHP Trevor McDonald vs. RHP Roki Sasaki
McDonald (1-0, 1.29 ERA) will make his second start of 2026 and his sixth career appearance. He has a 0.29 WHIP, 0.0 BB/9 and 10.3 K/9 in 7 innings.
First start: Win, 7 IP, 1 ER, 2 H (1 solo HR), 0 BB, 8 K in 3-2 home victory vs. San Diego Padres last Monday2025 away splits (1 start, 2 appearances): 0-0, 3.38 ERA (8 IP, 3 ER), 0 HR, 2 BB, 4 KCareer vs. Dodgers (1 start): No-decision, 6 IP, 1 ER, 6 H, 1 BB, 3 K in 3-1 road victory Sept. 21, 2025
Sasaki (1-3, 5.97 ERA) will make his seventh start of 2026. He has a 1.67 WHIP, 4.7 BB/9 and 8.2 K/9 in 28 2/3 innings.
Last start: Loss, 6 IP, 3 ER, 5 H (1 HR), 2 BB, 4 K in 3-2 road loss vs. St. Louis Cardinals May 22026 home splits (3 starts): 1-2, 4.85 ERA (13 IP, 7 ER), 4 HR, 8 BB, 15 K, 1.85 WHIPHas never faced GiantsGiants at Dodgers odds
Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 2:37 p.m. ET.
Moneyline (ML): Giants +150 (bet $100 to win $150) | Dodgers -185 (bet $185 to win $100)Run line (RL)/Against the spread (ATS): Giants +1.5 (-140) | Dodgers -1.5 (+115)Over/Under (O/U): 9 (O: -110 | U: -110)
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Giants at Dodgers picks and predictionsPrediction
Giants 5, Dodgers 3
The GIANTS (+150) are worth a look in this series opener as moderate underdogs behind McDonald.
San Francisco won 2 low-scoring games in a 3-game set, and we’re picking against Sasaki here, even though the game is in Los Angeles. He has been rather shaky this season.
BACKING GIANTS +1.5 (-140) isn’t a bad play if you’re a bit more on the conservative side, and you just can’t bring yourself to back San Francisco straight up.
The Dodgers can’t be trusted to win by multiple runs, as Sasaski has been giving, and L.A. lost 2 of 3 low-scoring games against the Giants in the first go-around.
UNDER 9 (-110) is the lean, but go with a half-unit play at best.
While Sasaki has been giving, these teams combined for just 10 total runs in a 3-game set 3 weeks ago. The Under is 4-1 in the past 5 games at home for the Dodgers, too. The Over-Under is 3-3 in Sasaki’s 6 outings this season.
For the Giants, the Over cashed in the final 2 games of the Pirates series at home over the weekend, but the Under is 6-3 in the past 9 outings, and 8-4 across the previous 12 contests.
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