June 12, 2026, 4:34 p.m. ET
The Chicago Cubs (35-34) and the San Francisco Giants (28-41) open a 3-game series Friday at Oracle Park in San Francisco, California. First pitch is scheduled for 10:15 p.m. ET. Let’s analyze MLB odds around the Cubs vs. Giants odds and make our expert MLB picks and predictions for the best bets.
Season series: Giants lead 2-1
The Giants won 2 of 3 games in the first series at Wrigley Field June 5-7, including an 18-3 beatdown in the series opener.
Chicago posted a 9-3 win in Colorado as moderate favorites (-148) cashed as the Over (11.5) hit Thursday, halting a 3-game skid and 4-game Under run. 3B Alex Bregman went 1 for 4 with a HR, 2 runs scored, 2 RBIs and a walk, while RF Seiya Suzuki had a grand slam.
The Cubs have dropped 7 of the past 10 games, while the Under has a 4-1 edge in the past 5 outings, while the total has gone low in 7 of the past 11 contests.
San Francisco outlasted Washington 11-10 in the series finale Wednesday as slight favorites (-112), salvaging the final contest of a 3-game set. The Over cashed in the final 2 installments. DH Bryce Eldredge went 1 for 4 with a grand slam, while 3B Matt Chapman finished 4 for 5 with a double, 2 HRs and 3 RBIs with 3 runs scored.
The Giants are still just 2-3 in the past 5 games, while the Under has a 3-2 edge in that span.
Watch MLB on Fubo!Cubs at Giants projected starters
RHP Javier Assad vs. RHP Landen Roupp
Assad (3-1, 4.73 ERA) makes his fourth start and 10th appearance. He has a 1.08 WHIP, 2.3 BB/9 and 5.3 K/9 in 32 1/3 innings.
Last start: No-decision, 6 1/3 IP, 0 ER, 1 H, 1 BB, 5 K in 2-1 home loss in 10 innings Sunday2026 road splits (2 starts, 5 appearances): 2-1, 8.00 ERA (18 IP, 16 ER), 3 HR, 7 BB, 10 K, 1.67 WHIPCareer vs. Giants (1 starts, 3 appearances): 0-0, 2.70 ERA (13 1/3 IP, 4 ER), 1 HR, 4 BB, 13 K, 1.13 WHIP, 8.8 K/9
Roupp (5-6, 4.00 ERA) makes his 14th start. He has a 1.29 WHIP, 3.9 BB/9 and 10.0 K/9 in 69 2/3 innings.
Last start: No-decision, 5 2/3 IP, 1 ER, 3 H (1 solo HR), 3 BB, 5 K in 3-2 in road loss in 10 innings at Cubs Saturday2026 home splits (5 starts): 2-3, 4.10 ERA (26 1/3 IP, 12 ER), 2 HR, 12 BB, 35 K, 1.22 WHIPCareer vs. Cubs (2 starts): 0-1, 2.53 ERA (10 2/3 IP, 3 ER), 2 HR, 3 BB, 9 K, 1.03 WHIP, 7.6 K/9Cubs at Giants odds
Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 2:31 p.m. ET.
Moneyline (ML): Cubs +105 (bet $100 to win $105) | Giants -125 (bet $125 to win $100)Run line (RL)/Against the spread (ATS): Cubs +1.5 (-200) | Giants -1.5 (+165)Over/Under (O/U): 8.5 (O: -105 | U: -115)
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Cubs at Giants picks and predictionsPrediction
Giants 5, Cubs 4
The GIANTS (-125) are worth playing lightly, as the home side has a slight edge with Roupp on the hill. Assad has struggled on the road, and San Francisco has won 2 of 3 meetings with Chicago this season. Don’t get carried away, though.
The Cubs +1.5 (-200) are way too risky if you need some insurance, as Chicago costs you more than 2 times your potential return. If you like Chicago, just bet it straight up.
PASS.
OVER 8.5 (-105) is worth playing lightly, but go with a half-unit at the very most.
While the Over cashed for the Cubs in Colorado Thursday, the Under is 4-1 in the past 5 outings. The Under is 4-1 in the past 5 road games, too, so tread lightly.
For San Francisco, the Over has cashed in the past 2 games, but the Under is 3-2 in the past 5 games, including 2 meetings with the Cubbies.
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