Division rivals San Francisco (6-4) and Arizona (3-6) will meet in a matchup of NFC West teams on Sunday, November 16, 2025 at State Farm Stadium. The 49ers are listed as favorites in this one, with the spread sitting at 3.5 points. The over/under is set at 48.5 in the outing.
Against the Seattle Seahawks in their most recent game, the Cardinals lost 44-22.
The Cards’ Jacoby Brissett went 22-for-44 for 258 yards versus the Seahawks, with two TDs and no INTs.
Last time out, the 49ers fell to the Los Angeles Rams, with 42-26 being the final score.
Cardinals vs 49ers betting information
NFL odds courtesy of BetMGM Sportsbook. Odds updated Sunday at 12:59 a.m. ET. For a full list of sports betting odds, access USA TODAY Sports Betting Scores Odds Hub.
Need a news break? Check out the all new PLAY hub with puzzles, games and more!Spread favorite: San Francisco (-3.5)Moneyline: San Francisco (-191), Arizona (+158)Total: 48.5 pointsCardinals betting insightsArizona has one win against the spread, and is 1-3 overall, at home this year.The Cardinals have covered the spread five times in nine games with a set spread.Arizona is unbeaten ATS (1-0) as 3.5-point underdogs or greater at home.The Cardinals have an ATS record of 3-1 when playing as at least 3.5-point underdogs.In three of four games at home this year, Arizona has gone over the total.Games involving Cardinals have hit the over five times this season.Cardinals leadersBrissett: 1,118 PASS YDS / 186.3 YPG / 60.9% / 8 TD / 1 INT / 19 CAR / 82 RUSH YDS / 1 TDEmari Demercado: 26 CAR / 233 YDS / 33.3 YPG / 0 TD / 6 REC / 52 YDS / 7.4 YPG / 1 TDBam Knight: 48 CAR / 157 YDS / 22.4 YPG / 2 TD / 8 REC / 65 YDS / 9.3 YPG / 0 TDTrey McBride: 61 REC / 603 YDS / 67.0 YPG / 6 TDMarvin Harrison Jr.: 34 REC / 525 YDS / 58.3 YPG / 4 TDMichael Wilson: 22 REC / 231 YDS / 25.7 YPG / 1 TDCardinals vs 49ers game infoDate: Sunday, November 16, 2025Time: 4:05 p.m. ETCity: Glendale, ArizonaVenue: State Farm StadiumTV channel: FOXLive stream: Watch on Fubo (Regional restrictions may apply)Watch San Francisco 49ers vs. Arizona Cardinals on Fubo! (Regional restrictions may apply)
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