Updated Dec. 28, 2025, 12:30 a.m. ET<\/p>\n
The Chicago Bears<\/a> (11-4) and San Francisco 49ers<\/a> (11-4) meet for Sunday Night Football in Week 17 at Levi’s Stadium in Santa Clara, California. Kickoff is scheduled for 8:20 p.m. ET (NBC \/ Peacock). Let’s analyze BetMGM Sportsbook’s<\/a> NFL odds around the Bears vs. 49ers odds and make our expert NFL picks and predictions<\/a> for the best bets.<\/p>\n The 49ers lead the all-time series 36-33-1, including a 38-13 win over the Bears in last season’s meeting in Santa Clara on Dec. 8, 2024.<\/p>\n Chicago, which won the NFC North title Saturday night when the Green Bay Packers lost 41-24 to the Baltimore Ravens, won 22-16 in overtime against the Packers in an epic comeback, including a recovered onside kick late in regulation, leading to a field goal to force overtime, and a game-winning 46-yard TD pass from QB Caleb Williams to WR DJ Moore. The Bears have won 2 in a row, and 7 of the past 8 outings, while going 5-0-1 against the spread (ATS) in the past 6 games.<\/p>\n San Francisco routed the Indianapolis Colts 48-27 on Monday Night Football in Week 16, as QB Brock Purdy threw for 295 yards and 5 TDs, while RB Christian McCaffrey rushed for 115 yards, with TE George Kittle going for 7 catches, 115 yards and a score. The 49ers have won and covered in 5 straight outings as the Over cashed in the past 2 games.<\/p>\n The Niners last appeared on SNF in Week 7, topping the Atlanta Falcons 20-10 as a 1-point underdog as the Under (47) cashed.<\/p>\n Watch the NFL on Fubo!<\/a>Bears at 49ers odds<\/p>\n Provided by BetMGM Sportsbook<\/a>; access USA TODAY Sports Scores and Sports Betting Odds hub<\/a> for a full list. Lines last updated at 12:01 a.m. ET.<\/p>\n Moneyline (ML): Bears +165 (bet $100 to win $165) | 49ers -200 (bet $200 to win $100)Against the spread: Bears +3.5 (-115) | 49ers -3.5 (-105)Over\/Under (O\/U): 52.5 (O: -110 | U: -110)SUNDAY NIGHT FOOTBALL: Best prop bets<\/a>Bears at 49ers key injuries<\/p>\n Bears<\/p>\n DB Josh Blackwell (illness) questionableLB T.J. Edwards (glute) questionableDB C.J. Gardner-Johnson (knee) questionableDB Nick McCloud (illness) outOL Luke Newman (foot) questionableWR Rome Odunze (foot) outDB Nahshon Wright (hamstring, illness) questionable<\/p>\n 49ers<\/p>\n CB Renardo Green (neck) outTE George Kittle (ankle) questionableWR Ricky Pearsall (knee, ankle) questionableQB Kurtis Rourke (knee) out<\/p>\n The Huddle<\/a> has been turning players like you into winners for over 25 years. Custom fantasy football rankings, sleepers and tools are just a click away. Subscribe now<\/a>!<\/p>\n SUNDAY NIGHT FOOTBALL: Best prop bets<\/a>Bears at 49ers picks and predictionsPrediction<\/p>\n Bears 26, 49ers 23<\/p>\n The BEARS (+165) are worth a look as underdogs in this very important Sunday night game.<\/p>\n Chicago has already wrapped up the NFC North. But, even so, the Bears have a crack at the No. 1 seed in the NFC, and a first-round bye, so even with a division title, it won’t take its foot off the gas.<\/p>\n The BEARS +3.5 (-115) are worth playing as short dogs in this wildly important NFC showdown in the Bay Area.<\/p>\n Chicago is 3-0-1 ATS in the past 4 road games, and it is 5-0-1 ATS in the past 6 outings. The Bears just seem to be able to figure out how to get the job done, even when the outlook appears to be very dark.<\/p>\n The 49ers are obviously no slouch, either. They’ve won and covered 5 in a row, and someone has to lose. It just seems like Chicago is living a more charmed life.<\/p>\n UNDER 52.5 (-110) is the play in this titanic SNF battle.<\/p>\n The Over-Under has split in the past 4 games for San Francisco, while also going 2-2 in the past 4 games at home. The Under hit in the SNF game against Atlanta back in Week 7, too.<\/p>\n The Under is 3-1 in the past 4 games for Chicago, with the defense allowing 20 or fewer points in 5 of the past 7 outings, and the Under is 5-2 in that span.<\/p>\n For more sports betting picks and tips, check out SportsbookWire.com<\/a> and BetFTW<\/a>.<\/p>\n Follow @danieledobish on\u00a0Twitter\/X<\/a>.\u00a0Follow SportsbookWire on Twitter\/X<\/a> and like us on Facebook<\/a>.<\/p>\n Access more NFL coverage:<\/p>\n TheHuddle Fantasy Football<\/a> | BearsWire<\/a> | BengalsWire<\/a> | BillsWire<\/a> | BroncosWire<\/a> | BrownsWire<\/a> | BucsWire<\/a> | CardsWire<\/a> | ChargersWire<\/a> | ChiefsWire<\/a> | ColtsWire<\/a> | CommandersWire<\/a> | CowboysWire<\/a> | DolphinsWire<\/a> | EaglesWire<\/a> | FalconsWire<\/a> | GiantsWire<\/a> | JaguarsWire<\/a> | JetsWire<\/a> | LionsWire<\/a> | NinersWire<\/a> | PackersWire<\/a> | PanthersWire<\/a> | PatriotsWire<\/a> | RaidersWire<\/a> | RamsWire<\/a> | RavensWire<\/a> | SaintsWire<\/a> | SeahawksWire<\/a> | SteelersWire<\/a> | TexansWire<\/a> |\u00a0TitansWire<\/a> | VikingsWire<\/a> | DraftWire<\/a> | TouchdownWire<\/a> | ListWire<\/a><\/p>\n Our team of savvy editors independently handpicks all recommendations. 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