April 11, 2026, 10:00 a.m. ET<\/p>\n
The San Francisco Giants<\/a> (6-8) and the Baltimore Orioles<\/a> (6-7) play the second game of their 3-game series Saturday at Oriole Park at Camden Yards in Baltimore,\u00a0Maryland. First pitch is scheduled for 7:15 p.m. ET (FOX). Let’s analyze MLB odds around the Giants vs. Orioles odds and make our expert MLB picks and predictions<\/a> for the best bets.<\/p>\n Season series: Giants lead 1-0<\/p>\n The Giants opened the series with a 6-3 win over the Orioles as +100 road underdogs, with the Over (8.5) cashing. SP Landen Roupp (1 ER, 5 H, 2 BB, 4 K) delivered 6 strong innings, while SS Willy Adames and RF Jung Hoo Lee homered. San Francisco has now won 3 straight.<\/p>\n The Orioles saw their 3-game win streak snapped Friday. SP Shane Baz (5 IP, 3 ER, 9 H, 2 BB, 4 K, 1 HR) continued to struggle, remaining winless since signing a contract extension March 27. SS Gunnar Henderson provided a 2-run homer, but 1B Pete Alonso went hitless with 2 strikeouts, leaving 3 runners on base.<\/p>\n Watch MLB on Fubo!<\/a>Giants at Orioles projected starters<\/p>\n RHP Logan Webb vs. RHP Chris Bassitt<\/p>\n Webb (1-1, 5.00 ERA) is making his fourth start. He has a 1.39 WHIP, 3.0 BB\/9 and 7.5 K\/9 through 18 innings.<\/p>\n Last start: No-decision, 7 IP, 1 ER, 7 H, 1 BB, 3 K (92 pitches) in 5-2 loss against the New York Mets on SundayLast start vs. Orioles: No-decision, 5 IP, 3 ER, 4 H, 2 BB, 8 K in 5-3 road defeat Sept. 19, 2024Career vs. Orioles: 0-1, 4.50 ERA (12 IP, 6 ER), 0.92 WHIP, 8 H, 3 BB, 14 K in 2 starts2025 on road: 7-7, 3.36 ERA (91 IP, 34 ER), 1.25 WHIP, 9.7 K\/9 in 15 starts<\/p>\n Bassitt (0-2, 14.21 ERA) is making his third start. He has a 2.84 WHIP, 8.5 BB\/9 and 4.3 K\/9 through 6 1\/3 innings.<\/p>\n Last start: Loss, 2 IP, 6 ER, 6 H, 2 BB, 0 K (62 pitches) in 8-2 road loss at Pittsburgh on SundayLast start vs. Giants: Win, 6 1\/3 IP, 0 ER, 10 H, 0 BB, 5 K in 4-0 home victory July 18, 2025, as a member of the Toronto Blue JaysCareer vs. Giants: 4-2, 3.91 ERA (46 IP, 20 ER), 1.30 WHIP, 46 H, 14 BB, 49 K in 8 starts2025 at home: 8-0, 2.71 ERA (93 IP, 28 ER), 1.17 WHIP, 9.7 K\/9 in 16 startsGiants at Orioles odds<\/p>\n Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub<\/a> for a full list. Lines last updated at 9:50 a.m. ET.<\/p>\n Moneyline (ML): Giants -120 (bet $120 to win $100) | Orioles +100 (bet $100 to win $100)Run line (RL)\/Against the spread (ATS): Giants -1.5 (+145) | Orioles +1.5 (-175)Over\/Under (O\/U): 7.5 (O: +100 | U: -120)<\/p>\n Slide into: BaseballHQ.com<\/a> for your fantasy baseball news. For decades, BHQ has been helping players just like you win! BHQ offers full-season subscriptions. Sign up today<\/a>!<\/p>\n Giants at Orioles picks and predictionsPrediction<\/p>\n Giants 5, Orioles 4<\/p>\n BET GIANTS (-120).<\/p>\n The Giants come into this matchup with momentum, winning 3 straight while outscoring opponents 17-3. After a slow start at the plate, the offense is beginning to find its rhythm, with contributions from Adames and Lee leading the way.<\/p>\n On the mound, Webb gives San Francisco a clear edge, while Baltimore turns to Bassitt, who has struggled early with command and limiting damage. That sets up favorable scoring chances for the Giants, especially against left-handed matchups.<\/p>\n With better recent form, a reliable starter and an offense starting to click, San Francisco is in a strong position to keep its streak going and deliver value on the moneyline.<\/p>\n PASS. I don’t have any interest in the run line for this game.<\/p>\n BET OVER 7.5 (+100).<\/p>\n Eight straight meetings between the Giants and Orioles have gone Over, and the trend continues to point that way. San Francisco has scored 5 plus runs in 3 straight games, and the Over is 6-2-2 in its last 10. With Bassitt struggling early, both teams should find scoring opportunities again.<\/p>\n For more sports betting picks and tips, check out SportsbookWire.com<\/a> and BetFTW<\/a>.<\/p>\n Follow SportsbookWire on Twitter\/X<\/a> and like us on Facebook<\/a>.<\/p>\n