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amine chakour \/\/ Shutterstock <\/p>\n
Every season in the NFL produces performances that feel less like a single game and more like statistical outliers – explosive outings where quarterbacks pile up passing yards, running backs break off long scoring runs, and receivers turn routine targets into multi-touchdown afternoons. These are the kinds of games that separate good fantasy weeks from historic ones.<\/p>\n
Stacker<\/a> compiled a ranking of the best San Francisco 49ers fantasy performances in 2025 using data from Stathead<\/a>. The list includes the highest single-game fantasy scores by quarterbacks, running backs, wide receivers, and tight ends. Players are ranked based on standard fantasy scoring.<\/p>\n Best quarterback fantasy games<\/p>\n #10. Brock Purdy, January 11, 2026<\/p>\n – Stats: 262 Passing Yards, 2 Passing TDs, 2 Interceptions, 24 Rushing Yards<\/p>\n – Game: SFO vs PHI, 23-19 Win<\/p>\n – Fantasy points: 16.88<\/p>\n #9. Brock Purdy, November 30, 2025<\/p>\n – Stats: 168 Passing Yards, 1 Passing TDs, 0 Interceptions, 1 Rushing TDs<\/p>\n – Game: SFO vs CLE, 26-8 Win<\/p>\n – Fantasy points: 17.12<\/p>\n #8. Brock Purdy, September 28, 2025<\/p>\n – Stats: 309 Passing Yards, 2 Passing TDs, 2 Interceptions, 13 Rushing Yards<\/p>\n – Game: SFO vs JAX, 21-26 Loss<\/p>\n – Fantasy points: 17.66<\/p>\n #7. Mac Jones, October 26, 2025<\/p>\n – Stats: 193 Passing Yards, 2 Passing TDs, 1 Interceptions, 23 Rushing Yards<\/p>\n – Game: SFO vs HOU, 15-26 Loss<\/p>\n – Fantasy points: 18.02<\/p>\n #6. Mac Jones, September 14, 2025<\/p>\n – Stats: 279 Passing Yards, 3 Passing TDs, 0 Interceptions<\/p>\n – Game: SFO vs NOR, 26-21 Win<\/p>\n – Fantasy points: 21.76<\/p>\n #5. Mac Jones, October 2, 2025<\/p>\n – Stats: 342 Passing Yards, 2 Passing TDs, 0 Interceptions<\/p>\n – Game: SFO vs LAR, 26-23 (OT) Win<\/p>\n – Fantasy points: 22.18<\/p>\n #4. Mac Jones, November 9, 2025<\/p>\n – Stats: 319 Passing Yards, 3 Passing TDs, 1 Interceptions<\/p>\n – Game: SFO vs LAR, 26-42 Loss<\/p>\n – Fantasy points: 23.06<\/p>\n #3. Brock Purdy, December 14, 2025<\/p>\n – Stats: 295 Passing Yards, 3 Passing TDs, 0 Interceptions, 44 Rushing Yards<\/p>\n – Game: SFO vs TEN, 37-24 Win<\/p>\n – Fantasy points: 26.2<\/p>\n #2. Brock Purdy, December 22, 2025<\/p>\n – Stats: 295 Passing Yards, 5 Passing TDs, 1 Interceptions, 11 Rushing Yards<\/p>\n – Game: SFO vs IND, 48-27 Win<\/p>\n – Fantasy points: 30.9<\/p>\n #1. Brock Purdy, December 28, 2025<\/p>\n – Stats: 303 Passing Yards, 3 Passing TDs, 1 Interceptions, 28 Rushing Yards, 2 Rushing TDs<\/p>\n – Game: SFO vs CHI, 42-38 Win<\/p>\n – Fantasy points: 36.92<\/p>\n Best running back fantasy games<\/p>\n #10. Christian McCaffrey, October 12, 2025<\/p>\n – Stats: 54 Rushing Yards, 1 Rushing TDs, 57 Receiving Yards<\/p>\n – Game: SFO vs TAM, 19-30 Loss<\/p>\n – Fantasy points: 17.1<\/p>\n #9. Christian McCaffrey, October 2, 2025<\/p>\n – Stats: 57 Rushing Yards, 0 Rushing TDs, 82 Receiving Yards, 1 Receiving TDs<\/p>\n – Game: SFO vs LAR, 26-23 (OT) Win<\/p>\n – Fantasy points: 19.9<\/p>\n #8. Christian McCaffrey, September 28, 2025<\/p>\n – Stats: 49 Rushing Yards, 0 Rushing TDs, 92 Receiving Yards, 1 Receiving TDs<\/p>\n – Game: SFO vs JAX, 21-26 Loss<\/p>\n – Fantasy points: 20.1<\/p>\n #7. Christian McCaffrey, November 24, 2025<\/p>\n – Stats: 89 Rushing Yards, 1 Rushing TDs, 53 Receiving Yards<\/p>\n – Game: SFO vs CAR, 20-9 Win<\/p>\n – Fantasy points: 20.2<\/p>\n #6. Christian McCaffrey, January 11, 2026<\/p>\n – Stats: 48 Rushing Yards, 0 Rushing TDs, 66 Receiving Yards, 2 Receiving TDs<\/p>\n – Game: SFO vs PHI, 23-19 Win<\/p>\n – Fantasy points: 23.4<\/p>\n #5. Christian McCaffrey, December 28, 2025<\/p>\n – Stats: 140 Rushing Yards, 1 Rushing TDs, 41 Receiving Yards<\/p>\n – Game: SFO vs CHI, 42-38 Win<\/p>\n – Fantasy points: 24.1<\/p>\n #4. Christian McCaffrey, December 22, 2025<\/p>\n – Stats: 117 Rushing Yards, 0 Rushing TDs, 29 Receiving Yards, 2 Receiving TDs<\/p>\n – Game: SFO vs IND, 48-27 Win<\/p>\n – Fantasy points: 26.6<\/p>\n #3. Christian McCaffrey, November 2, 2025<\/p>\n – Stats: 106 Rushing Yards, 1 Rushing TDs, 67 Receiving Yards, 1 Receiving TDs<\/p>\n – Game: SFO vs NYG, 34-24 Win<\/p>\n – Fantasy points: 29.3<\/p>\n #2. Christian McCaffrey, November 16, 2025<\/p>\n – Stats: 81 Rushing Yards, 2 Rushing TDs, 40 Receiving Yards, 1 Receiving TDs<\/p>\n – Game: SFO vs ARI, 41-22 Win<\/p>\n – Fantasy points: 30.1<\/p>\n #1. Christian McCaffrey, October 19, 2025<\/p>\n – Stats: 129 Rushing Yards, 2 Rushing TDs, 72 Receiving Yards<\/p>\n – Game: SFO vs ATL, 20-10 Win<\/p>\n – Fantasy points: 32.1<\/p>\n Best wide receiver fantasy games<\/p>\n #10. Jauan Jennings, December 28, 2025<\/p>\n – Stats: 42 Receiving Yards, 1 Receiving TDs, 2 Receptions, 4 Targets<\/p>\n – Game: SFO vs CHI, 42-38 Win<\/p>\n – Fantasy points: 10.2<\/p>\n #9. Ricky Pearsall, September 7, 2025<\/p>\n – Stats: 108 Receiving Yards, 0 Receiving TDs, 4 Receptions, 7 Targets<\/p>\n – Game: SFO vs SEA, 17-13 Win<\/p>\n – Fantasy points: 10.8<\/p>\n #8. Jauan Jennings, November 9, 2025<\/p>\n – Stats: 71 Receiving Yards, 1 Receiving TDs, 6 Receptions, 9 Targets<\/p>\n – Game: SFO vs LAR, 26-42 Loss<\/p>\n – Fantasy points: 11.1<\/p>\n #7. Ricky Pearsall, September 21, 2025<\/p>\n – Stats: 117 Receiving Yards, 0 Receiving TDs, 8 Receptions, 11 Targets<\/p>\n – Game: SFO vs ARI, 16-15 Win<\/p>\n – Fantasy points: 11.7<\/p>\n #6. Jauan Jennings, December 22, 2025<\/p>\n – Stats: 71 Receiving Yards, 1 Receiving TDs, 5 Receptions, 6 Targets<\/p>\n – Game: SFO vs IND, 48-27 Win<\/p>\n – Fantasy points: 13.1<\/p>\n #5. Kendrick Bourne, October 12, 2025<\/p>\n – Stats: 142 Receiving Yards, 0 Receiving TDs, 5 Receptions, 9 Targets<\/p>\n – Game: SFO vs TAM, 19-30 Loss<\/p>\n – Fantasy points: 14.2<\/p>\n #4. Kendrick Bourne, October 2, 2025<\/p>\n – Stats: 142 Receiving Yards, 0 Receiving TDs, 10 Receptions, 11 Targets<\/p>\n – Game: SFO vs LAR, 26-23 (OT) Win<\/p>\n – Fantasy points: 14.2<\/p>\n #3. Jauan Jennings, September 14, 2025<\/p>\n – Stats: 89 Receiving Yards, 1 Receiving TDs, 5 Receptions, 10 Targets<\/p>\n – Game: SFO vs NOR, 26-21 Win<\/p>\n – Fantasy points: 14.9<\/p>\n #2. Jauan Jennings, December 14, 2025<\/p>\n – Stats: 37 Receiving Yards, 2 Receiving TDs, 3 Receptions, 5 Targets<\/p>\n – Game: SFO vs TEN, 37-24 Win<\/p>\n – Fantasy points: 15.7<\/p>\n #1. Demarcus Robinson, January 11, 2026<\/p>\n – Stats: 111 Receiving Yards, 1 Receiving TDs, 6 Receptions, 7 Targets<\/p>\n – Game: SFO vs PHI, 23-19 Win<\/p>\n – Fantasy points: 17.1<\/p>\n Best tight end fantasy games<\/p>\n #10. George Kittle, November 24, 2025<\/p>\n – Stats: 78 Receiving Yards, 0 Receiving TDs, 6 Receptions, 10 Targets<\/p>\n – Game: SFO vs CAR, 20-9 Win<\/p>\n – Fantasy points: 7.8<\/p>\n #9. George Kittle, September 7, 2025<\/p>\n – Stats: 25 Receiving Yards, 1 Receiving TDs, 4 Receptions, 4 Targets<\/p>\n – Game: SFO vs SEA, 17-13 Win<\/p>\n – Fantasy points: 8.5<\/p>\n #8. Jake Tonges, October 2, 2025<\/p>\n – Stats: 41 Receiving Yards, 1 Receiving TDs, 7 Receptions, 11 Targets<\/p>\n – Game: SFO vs LAR, 26-23 (OT) Win<\/p>\n – Fantasy points: 10.1<\/p>\n #7. George Kittle, October 26, 2025<\/p>\n – Stats: 43 Receiving Yards, 1 Receiving TDs, 4 Receptions, 5 Targets<\/p>\n – Game: SFO vs HOU, 15-26 Loss<\/p>\n – Fantasy points: 10.3<\/p>\n #6. Jake Tonges, September 28, 2025<\/p>\n – Stats: 58 Receiving Yards, 1 Receiving TDs, 3 Receptions, 5 Targets<\/p>\n – Game: SFO vs JAX, 21-26 Loss<\/p>\n – Fantasy points: 11.8<\/p>\n #5. Jake Tonges, December 28, 2025<\/p>\n – Stats: 60 Receiving Yards, 1 Receiving TDs, 7 Receptions, 9 Targets<\/p>\n – Game: SFO vs CHI, 42-38 Win<\/p>\n – Fantasy points: 12.0<\/p>\n #4. George Kittle, November 9, 2025<\/p>\n – Stats: 84 Receiving Yards, 1 Receiving TDs, 9 Receptions, 9 Targets<\/p>\n – Game: SFO vs LAR, 26-42 Loss<\/p>\n – Fantasy points: 14.4<\/p>\n #3. George Kittle, December 14, 2025<\/p>\n – Stats: 88 Receiving Yards, 1 Receiving TDs, 8 Receptions, 9 Targets<\/p>\n – Game: SFO vs TEN, 37-24 Win<\/p>\n – Fantasy points: 14.8<\/p>\n #2. George Kittle, December 22, 2025<\/p>\n – Stats: 115 Receiving Yards, 1 Receiving TDs, 7 Receptions, 8 Targets<\/p>\n – Game: SFO vs IND, 48-27 Win<\/p>\n – Fantasy points: 17.5<\/p>\n #1. George Kittle, November 16, 2025<\/p>\n – Stats: 67 Receiving Yards, 2 Receiving TDs, 6 Receptions, 6 Targets<\/p>\n – Game: SFO vs ARI, 41-22 Win<\/p>\n – Fantasy points: 18.7<\/p>\n Copyright 2026 Stacker Media, LLC<\/p>\n This story was originally published August 21, 2026 at 4:03 AM.<\/p>\n","protected":false},"excerpt":{"rendered":"amine chakour \/\/ Shutterstock Every season in the NFL produces performances that feel less like a single game…\n","protected":false},"author":2,"featured_media":439562,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[30],"tags":[101,103,102,104,106,105],"class_list":["post-439561","post","type-post","status-publish","format-standard","has-post-thumbnail","category-san-francisco","tag-san-francisco","tag-san-francisco-headlines","tag-san-francisco-news","tag-sf","tag-sf-headlines","tag-sf-news"],"_links":{"self":[{"href":"https:\/\/www.newsbeep.com\/us-ca\/wp-json\/wp\/v2\/posts\/439561","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.newsbeep.com\/us-ca\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.newsbeep.com\/us-ca\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/us-ca\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/us-ca\/wp-json\/wp\/v2\/comments?post=439561"}],"version-history":[{"count":0,"href":"https:\/\/www.newsbeep.com\/us-ca\/wp-json\/wp\/v2\/posts\/439561\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/us-ca\/wp-json\/wp\/v2\/media\/439562"}],"wp:attachment":[{"href":"https:\/\/www.newsbeep.com\/us-ca\/wp-json\/wp\/v2\/media?parent=439561"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.newsbeep.com\/us-ca\/wp-json\/wp\/v2\/categories?post=439561"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.newsbeep.com\/us-ca\/wp-json\/wp\/v2\/tags?post=439561"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}