9.5 (Over -146\/Under +120)10.5 (Over +125\/Under -150)<\/p>\n
DraftKings has an interesting couple of betting lines for the 49ers win total, as they are heavily favored to finish with more than nine wins but also heavily favored to finish with less than 11 wins. So, it\u2019s pretty clear that the market views this squad as a 10-win team.<\/p>\n
Health is going to be the biggest obstacle for this veteran team, as last year\u2019s squad dealt with a ton of injuries, including one that kept Brock Purdy sidelined for a good chunk of the regular season.<\/p>\n
Already, we\u2019ve seen the 49ers lose Ricky Pearsall for the year, and they brought back Deebo Samuel to help fix their issues at the receiver position.\u00a0<\/p>\n
Fred Warner should be back and ready to go for Week 1 while Nick Bosa and George Kittle are working their way back after dealing with season-ending injuries in 2025. Despite all of that, the team still finished with a 12-5 record and Mac Jones showed that he can step in and lead the team to wins if Purdy is forced to miss time.<\/p>\n
Kyle Shanahan is one of the best offensive minds in the sport, and the 49ers do benefit from the strength of the NFC West, as they\u2019ll play a third-place schedule in 2026.\u00a0<\/p>\n
Yes, they have four games that will be against either the Los Angeles Rams or Seattle Seahawks, but there are only three other games on the 49ers schedule against playoff teams from 2025 (Denver, Philadelphia and the Los Angeles Chargers).<\/p>\n
I think that puts this group in a great spot to make the playoffs, and the 10-win mark seems very achievable when looking at some of the 49ers\u2019 opponents. I counted six games that they\u2019ll likely be pretty sizable favorites in, including multiple road games:\u00a0<\/p>\n
Week 2: Home vs. MiamiWeek 3: Home vs. ArizonaWeek 7: @ AtlantaWeek 9 (off a bye): Home vs. Las VegasWeek 13: @ NYGWeek 18: @ Arizona<\/p>\n
The injuries will always be a story with this aging team, but I do believe in the talent on both sides of the ball, especially after last season\u2019s gritty performance to make the playoffs. <\/p>\n
Odds refresh periodically and are subject to change.<\/p>\n
If you or someone you know has a gambling problem and wants help, call 1-800-GAMBLER.<\/p>\n
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