{"id":480576,"date":"2026-09-30T15:48:14","date_gmt":"2026-09-30T15:48:14","guid":{"rendered":"https:\/\/www.newsbeep.com\/us-ca\/480576\/"},"modified":"2026-09-30T15:48:14","modified_gmt":"2026-09-30T15:48:14","slug":"california-professor-who-pioneered-medicinal-trojan-horses-awarded-prestigious-macarthur-genius-grant-the-mercury-news","status":"publish","type":"post","link":"https:\/\/www.newsbeep.com\/us-ca\/480576\/","title":{"rendered":"California professor who pioneered medicinal Trojan horses awarded prestigious MacArthur \u2018genius grant\u2019 \u2013 The Mercury News"},"content":{"rendered":"<p>As a chemical engineer, UC San Diego professor Liangfang Zhang could have opted for career paths that had nothing to do with medicine or the greater human good. Yet for more than 15 years, Zhang has used his expertise to figure out how to disguise microscopic nanoparticles that can bypass the human immune system and precisely target ailments inside the body.<\/p>\n<p>The hope is that this novel technology pioneered by Zhang, chair of the Department of Chemical and Nano Engineering at the UC San Diego Jacobs School of Engineering, will one day be used to treat and prevent numerous diseases and medical disorders, including cancer.<\/p>\n<p>For creating that technology, Zhang was named Tuesday as one of the John D. and Catherine T. MacArthur Foundation\u2019s 2026 fellows. The prestigious <a href=\"https:\/\/www.macfound.org\/programs\/awards\/fellows\/about\" target=\"_blank\" rel=\"noopener nofollow\">MacArthur fellowship<\/a>, typically awarded to about two dozen individuals each year, comes with an $800,000 prize that\u2019s often called the \u201cgenius grant.\u201d The money is paid directly to individual winners, not the institutions they work for, and can be spent however each fellow chooses.<\/p>\n<p>\u201cA MacArthur fellowship is very important, not just to (my) field, but to the general public,\u201d Zhang told the Union-Tribune in an interview. \u201cThis is a very big deal to me personally, but more importantly, I feel it\u2019s a greater recognition (of) the work that myself and my teams have been working on over the past 16 years to develop this unique nano medicine technology.\u201d<\/p>\n<p>Zhang, 46, said he and his colleagues know how \u201cvery innovative, and potentially very powerful\u201d that technology can be. But he hopes the MacArthur award, which draws national headlines each year, will help broadcast its importance to a wider audience.<\/p>\n<p>\u201cI think with this type of recognition, it\u2019s really helpful and very meaningful,\u201d Zhang said.<\/p>\n<p>Since 1981, the MacArthur Foundation has honored 1,195 <a href=\"https:\/\/www.macfound.org\/programs\/awards\/fellows\/search\" target=\"_blank\" rel=\"noopener nofollow\">MacArthur fellows<\/a>. Zhang is among 20 fellows honored in 2026, the program\u2019s 45th year. Four other scientists were also named fellows this year, alongside artists, fiction writers, historians, a dancer, a saxophonist and a poet. The fellows are chosen each year based on three criteria, according to the foundation: exceptional creativity; promise for important future advances based on past accomplishments; and the potential for the fellowship to enable subsequent creative work.<\/p>\n<p>MacArthur fellows are not involved at all in the nomination or selection process, so the award comes as a complete surprise to each new fellow every year. Zhang said he had just dropped his daughter off at school on a recent morning when he received a call from an unknown number. Because he was not yet at work, he decided to answer.<\/p>\n<p>The person on the other end of the call asked him to verify his identity and inquired if there was somewhere private he could talk. Zhang was extremely suspicious, he recalled with a laugh. But eventually the caller, Marlies Carruth, the director of the MacArthur Fellows Program, broke the news.<\/p>\n<p>\u201cMy first reaction when she told me that, I feel that it\u2019s not real,\u201d Zhang said. \u201cI never expected that I will receive a call like this.\u201d<\/p>\n<p>Zhang, who has worked at UCSD since 2008, is the fifth current faculty member to receive a MacArthur award, according to a spokesperson. Several emeritus faculty have also been recipients.<\/p>\n<p>\u201cUC San Diego congratulates Professor Liangfang Zhang on this tremendous, well-deserved honor,\u201d Chancellor Pradeep Khosla said in a statement. \u201cProfessor Zhang has turned cellular membranes into a platform technology to deliver medicines and combat infectious disease and inflammation, with the ultimate goal of improving lives. His fundamental and translational research collaborations across campus, exceptional teaching and mentorship, and entrepreneurial leadership exemplify the caliber of our world-class faculty.\u201d<\/p>\n<p>Zhang\u2019s work has essentially centered on a <a href=\"https:\/\/nano.ucsd.edu\/~l7zhang\/groupnews\/San_Diego_Union_Tribune.pdf?_ga=2.232824286.1555856385.1664760746-1867673008.1663387560\" target=\"_blank\" rel=\"noopener nofollow\">Trojan horse strategy<\/a> of fighting diseases and ailments by coating drug-laden nanoparticles with the membranes of human cells. Cloaked in the membranes of these cells, the nanoparticles can slip past the body\u2019s immune system, which would typically seek to destroy such a foreign intrusion, and get to work treating whatever ailment they\u2019re designed to treat.<\/p>\n<p>The work began by using red blood cells to coat the nanoparticles, but has evolved over the years to also use two types of white blood cells and other cells in the human body. The recurring theme in his work is to use existing biological systems rather than design a new drug for every ailment.<\/p>\n<p>\u201cWe\u2019ve shown many examples of mimicking natural interactions in the body to create more effective therapies,\u201d Zhang said in a statement.<\/p>\n<p>Zhang told the Union-Tribune he has not decided how he\u2019ll use the $800,000 grant, which the MacArthur Foundation will pay out over five years.<\/p>\n<p>\u201cBut I think the most important thing is that we will continue to advance the technology,\u201d Zhang said, \u201cand realize the full potential to benefit people.\u201d<\/p>\n","protected":false},"excerpt":{"rendered":"As a chemical engineer, UC San Diego professor Liangfang Zhang could have opted for career paths that had&hellip;\n","protected":false},"author":2,"featured_media":480577,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[6],"tags":[387,7,9,8,15,1570,1280,2306,181,1338,100,645,1970],"class_list":["post-480576","post","type-post","status-publish","format-standard","has-post-thumbnail","category-california","tag-business","tag-california","tag-california-headlines","tag-california-news","tag-education","tag-health","tag-health-care","tag-higher-education","tag-latest-headlines","tag-morning-wire","tag-news","tag-science","tag-technology"],"_links":{"self":[{"href":"https:\/\/www.newsbeep.com\/us-ca\/wp-json\/wp\/v2\/posts\/480576","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.newsbeep.com\/us-ca\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.newsbeep.com\/us-ca\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/us-ca\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/us-ca\/wp-json\/wp\/v2\/comments?post=480576"}],"version-history":[{"count":0,"href":"https:\/\/www.newsbeep.com\/us-ca\/wp-json\/wp\/v2\/posts\/480576\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/us-ca\/wp-json\/wp\/v2\/media\/480577"}],"wp:attachment":[{"href":"https:\/\/www.newsbeep.com\/us-ca\/wp-json\/wp\/v2\/media?parent=480576"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.newsbeep.com\/us-ca\/wp-json\/wp\/v2\/categories?post=480576"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.newsbeep.com\/us-ca\/wp-json\/wp\/v2\/tags?post=480576"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}