{"id":484109,"date":"2026-10-03T18:03:20","date_gmt":"2026-10-03T18:03:20","guid":{"rendered":"https:\/\/www.newsbeep.com\/us-ca\/484109\/"},"modified":"2026-10-03T18:03:20","modified_gmt":"2026-10-03T18:03:20","slug":"nfl-predictions-denver-broncos-vs-san-francisco-49ers-score-predictions","status":"publish","type":"post","link":"https:\/\/www.newsbeep.com\/us-ca\/484109\/","title":{"rendered":"NFL predictions: Denver Broncos vs. San Francisco 49ers score predictions"},"content":{"rendered":"<p class=\"duet--article--dangerously-set-cms-markup duet--article--standard-paragraph _1upudxki _174s0un1 _174s0un0 _1mt21p01\">The Denver Broncos are coming off an historic back-to-back comeback wins where they would overcome two score deficits in both games to climb to 2-1 before heading west to take on the undefeated San Francisco 49ers. They are underdogs and the 49ers look pretty good to start the season. This one will put Denver to the test.<\/p>\n<p class=\"duet--article--dangerously-set-cms-markup duet--article--standard-paragraph _1upudxki _174s0un1 _174s0un0 _1mt21p01\">With the heat likely being a big factor in this game, Bo Nix and the offense must do a better job of controlling the clock and sustaining their drives. If they find themselves forcing the defense back out onto after multiple three-and-out\u2019s then this game could get ugly for them quickly.<\/p>\n<p class=\"duet--article--dangerously-set-cms-markup duet--article--standard-paragraph _1upudxki _174s0un1 _174s0un0 _1mt21p01\">Denver Broncos vs. San Francisco 49ers<br \/>Sunday, October 4, 2026 at 2:25 P.M. Mile High time<br \/>Levi\u2019s Stadium in Santa Clara, California<br \/>ATS Betting Lines: San Francisco -2.5<br \/>Moneyline Odds: Denver +124 \/ San Francisco -146<br \/>Over\/Under: 47.5<br \/><a href=\"https:\/\/sportsbook.fanduel.com\/navigation\/nfl\" rel=\"nofollow noopener\" target=\"_blank\">Note: All odds courtesy of FanDuel Sportsbook.<\/a><\/p>\n<p class=\"duet--article--dangerously-set-cms-markup duet--article--standard-paragraph _1upudxki _174s0un1 _174s0un0 _1mt21p01\">Collectively, our Mile High Report staff is predicting a narrow Broncos 24-23 victory on the road over the 49ers. Here\u2019s how we predicted the outcome individually:<\/p>\n<p class=\"duet--article--dangerously-set-cms-markup duet--article--standard-paragraph _1upudxki _174s0un1 _174s0un0 _1mt21p01\">This is one of those games where I think the Broncos won\u2019t be able to catch fire late. A combination of the heat, poor starts, and inability to sustain drives will catch Denver sleeping. They will mount a late drive, but the defense is too tired to rally. It\u2019s okay, though. Losing on the road to an NFC team is the \u201cbest\u201d kind of loss and the Broncos will bounce-back to win the next two games anyway. 4-2 through the first six games was always my target. &#8211; Tim Lynch<\/p>\n<p class=\"duet--article--dangerously-set-cms-markup duet--article--standard-paragraph _1upudxki _174s0un1 _174s0un0 _1mt21p01\">I think this is going to be a difficult matchup for the Broncos, but I have confidence they can get the job done on the road against the 49ers. The Broncos will have to play much better on offense. That includes starting off hot with a formidable rushing attack. On top of that, Vance Joseph\u2019s defense will have to find a way to slow down Brock Purdy, Christian McCaffrey, George Kittle, and the rest of the 49ers high-powered offense. Time of possession and the turnover battle will be huge. I think Denver finds a way to sneak out their third victory. &#8211; Chris Hart<\/p>\n<p class=\"duet--article--dangerously-set-cms-markup duet--article--standard-paragraph _1upudxki _174s0un1 _174s0un0 _1mt21p01\">There are a lot reasons the Broncos shouldn\u2019t win &#8211; Niners have a lot of weapons, a good QB, Christian McCaffrey, Trent Williams AND home field advantage. But they don\u2019t have Bo \u201cI will lead fourth quarter comebacks like a f boss and you will like it\u201d Nix. So Broncos come from behind and steal another one. &#8211; Laurie Lattimore-Volkmann<\/p>\n<p class=\"duet--article--dangerously-set-cms-markup duet--article--standard-paragraph _1upudxki _174s0un1 _174s0un0 _1mt21p01\">Broncos will trail 14-0 at halftime and 17-0 in the 3rd quarter but then they will score 27 unanswered all in the final 18 minutes of the game and win 27-17. &#8211; Scotty Payne<\/p>\n<p class=\"duet--article--dangerously-set-cms-markup duet--article--standard-paragraph _1upudxki _174s0un1 _174s0un0 _1mt21p01\">The future of this Broncos team looks very bright. But this week is a very tall order. I think the 49ers having home field advantage really dials up the difficulty for the Broncos. They also have a coach in Kyle Shanahan who\u2019s schemes will turn red zone trips into touchdowns. &#8211; Sadaraine<\/p>\n<p class=\"duet--article--dangerously-set-cms-markup duet--article--standard-paragraph _1upudxki _174s0un1 _174s0un0 _1mt21p01\">Nix and Denver have a resiliency that gives them an edge over every team. That belief and confidence that no matter what, the Broncos are in every game. The Denver offense will start faster on Sunday and it will make a concerted effort to run the ball. The defense will limit the big plays and keep Purdy and the San Francisco offense out of the end zone. Throw in a couple of sacks and turnovers for the defense, and the Broncos find a way yet again. &#8211; Ian St. Clair<\/p>\n<p class=\"duet--article--dangerously-set-cms-markup duet--article--standard-paragraph _1upudxki _174s0un1 _174s0un0 _1mt21p01\">This week is a huge test for the Broncos. Can the offense play a complete game? Can the defense shut down a consistent offense? I\u2019m not sure both of those things can happen. It should be a good game, and I think Denver passes the test. What they won\u2019t do is win. &#8211; Adam Malnati<\/p>\n<p>What is your score prediction for the Broncos-49ers game? Let us know in the comments section below.<\/p>\n","protected":false},"excerpt":{"rendered":"The Denver Broncos are coming off an historic back-to-back comeback wins where they would overcome two score deficits&hellip;\n","protected":false},"author":2,"featured_media":484110,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[30],"tags":[60516,101,103,102,104,106,105],"class_list":["post-484109","post","type-post","status-publish","format-standard","has-post-thumbnail","category-san-francisco","tag-denver-broncos-odds","tag-san-francisco","tag-san-francisco-headlines","tag-san-francisco-news","tag-sf","tag-sf-headlines","tag-sf-news"],"_links":{"self":[{"href":"https:\/\/www.newsbeep.com\/us-ca\/wp-json\/wp\/v2\/posts\/484109","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.newsbeep.com\/us-ca\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.newsbeep.com\/us-ca\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/us-ca\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/us-ca\/wp-json\/wp\/v2\/comments?post=484109"}],"version-history":[{"count":0,"href":"https:\/\/www.newsbeep.com\/us-ca\/wp-json\/wp\/v2\/posts\/484109\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/us-ca\/wp-json\/wp\/v2\/media\/484110"}],"wp:attachment":[{"href":"https:\/\/www.newsbeep.com\/us-ca\/wp-json\/wp\/v2\/media?parent=484109"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.newsbeep.com\/us-ca\/wp-json\/wp\/v2\/categories?post=484109"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.newsbeep.com\/us-ca\/wp-json\/wp\/v2\/tags?post=484109"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}