The San Francisco 49ers have finalized their inactive list ahead of their Week 5 matchup against the Seattle Seahawks at Lumen Field. With rosters limited to 48 active players on gameday, several players will be sidelined for Sunday’s contest.<\/p>\n
The 49ers entered Week 5 with four players ruled out on Friday’s final injury report. Defensive linemen Nick Bosa<\/a> (knee\/calf) and James Thompson Jr.<\/a> (ankle), fullback Kyle Juszczyk<\/a> (knee), and safety Marques Sigle<\/a>\u00a0(ankle) were all ruled out for Sunday’s matchup.<\/p>\n DL Mykel Williams<\/a> (knee) and CB Upton Stout<\/a> (shoulder), who were both listed as questionable entering the weekend, are active for Sunday’s game.<\/p>\n Williams is set to make his season debut after beginning the year on the reserve\/PUP list while recovering from an ACL injury suffered in Week 9 of the 2025 season. The defensive lineman returned to full participation in Friday’s practice and was elevated to the active roster ahead of Sunday’s matchup.<\/p>\n Here are the 49ers inactives for Week 5 against the Seattle Seahawks:<\/p>\n","protected":false},"excerpt":{"rendered":"The San Francisco 49ers have finalized their inactive list ahead of their Week 5 matchup against the Seattle…\n","protected":false},"author":2,"featured_media":492890,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[30],"tags":[51513,809,810,11613,808,100,101,190555,103,102,104,106,105,15311],"class_list":["post-492889","post","type-post","status-publish","format-standard","has-post-thumbnail","category-san-francisco","tag-brooke-evans","tag-english","tag-english-articles","tag-inactives","tag-latest-app","tag-news","tag-san-francisco","tag-san-francisco-49ers-at-seattle-seahawks-2026-reg-5","tag-san-francisco-headlines","tag-san-francisco-news","tag-sf","tag-sf-headlines","tag-sf-news","tag-sutter-health"],"_links":{"self":[{"href":"https:\/\/www.newsbeep.com\/us-ca\/wp-json\/wp\/v2\/posts\/492889","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.newsbeep.com\/us-ca\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.newsbeep.com\/us-ca\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/us-ca\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/us-ca\/wp-json\/wp\/v2\/comments?post=492889"}],"version-history":[{"count":0,"href":"https:\/\/www.newsbeep.com\/us-ca\/wp-json\/wp\/v2\/posts\/492889\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/us-ca\/wp-json\/wp\/v2\/media\/492890"}],"wp:attachment":[{"href":"https:\/\/www.newsbeep.com\/us-ca\/wp-json\/wp\/v2\/media?parent=492889"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.newsbeep.com\/us-ca\/wp-json\/wp\/v2\/categories?post=492889"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.newsbeep.com\/us-ca\/wp-json\/wp\/v2\/tags?post=492889"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}