The Buffalo Bills travel to Jacksonville this Sunday for an AFC Wild Card showdown against the No. 3 seed Jaguars. While the Bills (12-5) have reached the postseason for the seventh consecutive year, they arrive as the No. 6 seed after their five-year reign atop the AFC East was snapped by the New England Patriots.

Buffalo’s defense enters the playoffs with significant concerns, particularly on special teams following a quad injury to veteran kicker Matt Prater in the regular-season finale. The Jaguars (13-4), winners of eight consecutive games, enter as one of the league’s hottest teams under first-year head coach Liam Coen. Jacksonville’s resurgent offense, led by Trevor Lawrence and rushing star Travis Etienne, will look to exploit a Bills unit that has struggled against the run throughout the season.

The contrast between Buffalo’s postseason experience and Jacksonville’s late-season momentum prompted analysts to perform an immediate reevaluation of the opening lines. New simulations focus on whether Josh Allen can overcome a physical Jaguars pass rush while Buffalo’s shorthanded defense attempts to slow down a high-scoring Jacksonville attack.

The results of these simulations were compared to updated sportsbook odds to compile the data-driven Bills-Jaguars preview below.

Bills vs. Jaguars betting preview

Explore the interactive widget below to discover the latest spread, total, and moneyline odds and probabilities for the Bills-Jaguars matchup at EverBank Stadium.

This prediction and best bet for Sunday’s NFL matchup between the Bills and Jaguars is from Dimers.com, a trusted source for sports betting predictions.

Check out all the important details on today’s game, as well as the best odds sourced from the top sportsbooks in the country.

Game details

Key information on the Bills vs. Jaguars matchup, including where the game is and what time it kicks off.

Teams: Buffalo Bills vs. Jacksonville JaguarsDate: Sunday, January 11, 2026Kickoff: 1 p.m. ESTLocation: EverBank StadiumNFL standings: Current NFL division standingsNFL injuries: Check the latest updates to the official NFL injury reportOdds

Odds for the key markets in the Bills-Jaguars NFL game.

Spread: Bills -1.5 (-106), Jaguars +1.5 (-110)Moneyline: Bills -118, Jaguars +102Total: Over/Under 51.5 (-110/-105)

The odds and lines featured in this article are the best available from selected sports betting sites at the time of publication and are subject to change.

Promos

New users can take advantage of the $200 offer from Bet365 using the bonus code SYRACUSE.

Expert prediction: Bills vs. Jaguars

Leveraging cutting-edge data analysis and advanced algorithms, the experts at Dimers have executed 10,000 simulations of Sunday’s Bills vs. Jaguars matchup.

According to Dimers’ independent predictive analytics model, the Bills are more likely to beat the Jaguars at EverBank Stadium. This prediction is based on the model giving the Bills a 56% chance of winning the game.

Furthermore, Dimers predicts that the bookmakers have gotten it right and the Bills and Jaguars each have a 50% chance of covering the spread, while the over/under total of 51.5 points has a 54% chance of staying under.

These predictions and probabilities are accurate at the time of publication but are subject to change.

Bills vs. Jaguars best bet

Our top pick for the Bills vs. Jaguars game on Sunday is to bet on Under 51.5 points (-105).

This expert betting advice is based on world-class modeling and valuable wagering intelligence, designed to assist you in making smarter investments.

Score prediction for Bills vs. Jaguars

Dimers’ predicted final score for the Buffalo vs. Jacksonville game on Sunday has the Bills winning 25-24.

This expert prediction is based on each team’s average score following 10,000 game simulations, offering a glimpse into the potential outcome.

NFL player props: Sunday

NFL player prop bets are an enjoyable way to wager on Sunday’s game without necessarily betting on its outcome.

This article features the most likely first and anytime touchdown scorers for the Bills and Jaguars, as well as projected player stats.

Buffalo BillsFirst touchdown scorer predictionsJames Cook: 12.1% probabilityJosh Allen: 9.4% probabilityTy Johnson: 4.5% probabilityAnytime touchdown predictionsJames Cook: 59.6% probabilityJosh Allen: 50.7% probabilityTy Johnson: 28.9% probabilityProjected box score leadersQB passing yards: Josh Allen, 229 yardsReceiving yards: Khalil Shakir, 50 yardsRushing yards: James Cook, 90 yardsJacksonville JaguarsFirst touchdown scorer predictionsTravis Etienne: 12.8% probabilityTrevor Lawrence: 7.7% probabilityJakobi Meyers: 5.6% probabilityAnytime touchdown predictionsTravis Etienne: 54.8% probabilityTrevor Lawrence: 38.1% probabilityJakobi Meyers: 29.3% probabilityProjected box score leadersQB passing yards: Trevor Lawrence, 235 yardsReceiving yards: Jakobi Meyers, 57 yardsRushing yards: Travis Etienne, 66 yardsNFL Week 19: Bills vs. Jaguars

Get ready for Sunday’s action between the Bills and Jaguars in the Wild Card Round of the NFL season at EverBank Stadium, which is scheduled to start at 1 p.m. EST. We emphasize that all of the NFL best bets and NFL predictions in this article are based on 10,000 data-driven simulations of the Bills vs. Jaguars matchup, and they are correct at the time of publication to help you make better decisions when placing bets at online sportsbooks.

Please remember to gamble responsibly and consult reliable sources for the latest and most accurate information when making online betting choices.

If you or a loved one has questions or needs to talk to a professional about gambling, call 1-800-GAMBLER or visit 1800gambler.net for more information.

If you purchase a product or register for an account through a link on our site, we may receive compensation. By using this site, you consent to our User Agreement and agree that your clicks, interactions, and personal information may be collected, recorded, and/or stored by us and social media and other third-party partners in accordance with our Privacy Policy.